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Entry version 70 (18 Sep 2019)
Sequence version 1 (21 Sep 2011)
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Protein
Submitted name:

Amylo-1,6-glucosidase, 4-alpha-glucanotransferase

Gene

Agl

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6798695 Neutrophil degranulation
R-MMU-70221 Glycogen breakdown (glycogenolysis)

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH13 Glycoside Hydrolase Family 13
GH133 Glycoside Hydrolase Family 133

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Amylo-1,6-glucosidase, 4-alpha-glucanotransferaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AglImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924809 Agl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000033400 Expressed in 289 organ(s), highest expression level in knee joint

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000044012

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 116hGDE_NInterPro annotationAdd BLAST86
Domaini121 – 551hDGE_amylaseInterPro annotationAdd BLAST431
Domaini697 – 974hGDE_centralInterPro annotationAdd BLAST278
Domaini1072 – 1527GDE_CInterPro annotationAdd BLAST456

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3625 Eukaryota
COG3408 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012596

KEGG Orthology (KO)

More...
KOi
K01196

Identification of Orthologs from Complete Genome Data

More...
OMAi
FTGSEEM

Database of Orthologous Groups

More...
OrthoDBi
33175at2759

TreeFam database of animal gene trees

More...
TreeFami
TF300697

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11327 AmyAc_Glg_debranch_2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR010401 AGL/Gdb1
IPR032788 AGL_central
IPR029436 AGL_euk_N
IPR032792 AGL_glucanoTrfase
IPR032790 GDE_C
IPR006421 Glycogen_debranch_met
IPR017853 Glycoside_hydrolase_SF

The PANTHER Classification System

More...
PANTHERi
PTHR10569 PTHR10569, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06202 GDE_C, 1 hit
PF14701 hDGE_amylase, 1 hit
PF14702 hGDE_central, 1 hit
PF14699 hGDE_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48208 SSF48208, 1 hit
SSF51445 SSF51445, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01531 glyc_debranch, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

F8VPN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHSKQIRIL LLNEMEKLEK TLFRLEQGFE LQFRLGPTLQ GKAVTVYTNY
60 70 80 90 100
PLPGEAFNRE KFRSLDWENP TEREDDSDKY CKLHLQQSGS FQYYFLQGNE
110 120 130 140 150
KSGGGYIVVD PILRIGVDNH VLPLDCVTLQ TFLAKCLGPF DEWESRLRVA
160 170 180 190 200
KESGYNMIHF TPLQTLGLSR SCYSLADQLE LNPDFSRPSK RYTWSDVGQL
210 220 230 240 250
VEKLKREWNI LCITDVVYNH TATNSKWILE HPESAYNLVN SPHLKPAWVL
260 270 280 290 300
DRALWHFSCD VADGKYREKG VPALIENDQH MNCIRKIIWE DIFPRIQLWE
310 320 330 340 350
FFQVDVHKAV EQFRRLLSQE NRRVTKSEPK EHLKIIQDPE YRRRGCAVDM
360 370 380 390 400
DTALATFIPH DNGPAAIEEC CNWFRKRLEE LNSEKHHLTS CHQEQAVNCL
410 420 430 440 450
LGNVFYERLA GHGPKLGPVT RKYPLVTRYF TFPFGEMALS AEEALIHLPD
460 470 480 490 500
KACFLMAHNG WVMGDDPLRN FAEPGSDVYL RRELICWGDS VKLRYGNKPE
510 520 530 540 550
DCPYLWAHMK KYTEITATHF QGVRLDNCHS TPLHVAEYML DAARKLQPNL
560 570 580 590 600
YVVAELFTGS EELDNIFVTR LGISSLIREA MSAYNSHEEG RLVYRYGGEP
610 620 630 640 650
VGSFVQPCLR PLMPAIAHAL FMDITHDNEC PIVHRSAYDA LPSTTVVSMA
660 670 680 690 700
CCASGSTRGY DELVPHQISV VAEERFYTKW NPGASPADTG DVNVHSGIIA
710 720 730 740 750
ARCAINRLHQ ELGAKGFIQV YVDQVDEDIV AVTRHSPSIH QSVVAVSRTA
760 770 780 790 800
FRNPKTSFYS KEVPQMCIPG KIEEVVLEAR TIERNTKPYK KDENSINGMP
810 820 830 840 850
NMTVELREHI QLHESKIVRQ AGVATKGPNE YIQEIEFENL SPGSVIIFRV
860 870 880 890 900
SLDPHAQVAV GILRNHLTQF SSHFKSGSLA VDNADPILKI PFASIASKLT
910 920 930 940 950
LAELNQVLYR CESEEQEDGG GCYDIPNWSS LKYAGLQGLM SVLAEIRPKN
960 970 980 990 1000
DLGHPFCENL RSGDWMIDYV SGRLISRSGS IAEVGKWLQA MFFYLKQIPR
1010 1020 1030 1040 1050
YLIPCYFDAI LIGAYTTLLD VAWKQMSSFV QNGSTFVKHL SLGSVQMCGV
1060 1070 1080 1090 1100
GKCPCLPLLS PSLLDVPCRL NEITKEKEQC CASLAAGLPH FSSGLFRCWG
1110 1120 1130 1140 1150
RDTFIALRGM LLVTGRYLEA RNIILAFAST LRHGLIPNLL GEGTYARYNC
1160 1170 1180 1190 1200
RDAVWWWLQC IQDYCRTVPN GLDILKCPVS RMYPTDDSAP LPAGTLDQPL
1210 1220 1230 1240 1250
FEVIQEAMQR HMQGIQFRER NAGPQIDRNM KDEGFNITAG IDEETGFVYG
1260 1270 1280 1290 1300
GNRFNCGTWM DKMGESDRAR NRGIPATPRD GSAVEIVGLC KSAVRWLLEL
1310 1320 1330 1340 1350
SKKNIFPYHE VRVKRHGKVV AVSYDEWNRK IQNNFEKLFH VSEDPSDPNE
1360 1370 1380 1390 1400
KHPNLVHKRG IYKDSYGASS PWCDYQLRPN FTIAMVVAPE LFTAEKAWKA
1410 1420 1430 1440 1450
LEIAEKKLLG PLGMKTLDPD DMVYCGVYDN ALDNDNYNLA RGFNYHQGPE
1460 1470 1480 1490 1500
WLWPIGYFLR AKLYFSKMMG PETAAKTVFL VKNVLSRHYV HLERSPWKGL
1510 1520 1530
PELTNENGQY CPFSCETQAW SMAVVLETLY DL
Length:1,532
Mass (Da):174,287
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFD9FBB9C85B7443
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGI9A0A0G2JGI9_MOUSE
Amylo-1,6-glucosidase, 4-alpha-gluc...
Agl
1,279Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CYU6E0CYU6_MOUSE
Amylo-1,6-glucosidase, 4-alpha-gluc...
Agl
233Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XXE6F6XXE6_MOUSE
Amylo-1,6-glucosidase, 4-alpha-gluc...
Agl
830Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CSZ6F7CSZ6_MOUSE
Amylo-1,6-glucosidase, 4-alpha-gluc...
Agl
198Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CX86E0CX86_MOUSE
Amylo-1,6-glucosidase, 4-alpha-gluc...
Agl
116Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC147242 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001074795.1, NM_001081326.1
XP_006502350.1, XM_006502287.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000040603; ENSMUSP00000044012; ENSMUSG00000033400
ENSMUST00000162792; ENSMUSP00000124149; ENSMUSG00000033400

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
77559

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:77559

UCSC genome browser

More...
UCSCi
uc008rcq.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC147242 Genomic DNA No translation available.
RefSeqiNP_001074795.1, NM_001081326.1
XP_006502350.1, XM_006502287.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044012

Protein family/group databases

CAZyiGH13 Glycoside Hydrolase Family 13
GH133 Glycoside Hydrolase Family 133

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
77559

Genome annotation databases

EnsembliENSMUST00000040603; ENSMUSP00000044012; ENSMUSG00000033400
ENSMUST00000162792; ENSMUSP00000124149; ENSMUSG00000033400
GeneIDi77559
KEGGimmu:77559
UCSCiuc008rcq.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178
MGIiMGI:1924809 Agl

Phylogenomic databases

eggNOGiKOG3625 Eukaryota
COG3408 LUCA
GeneTreeiENSGT00390000012596
KOiK01196
OMAiFTGSEEM
OrthoDBi33175at2759
TreeFamiTF300697

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-70221 Glycogen breakdown (glycogenolysis)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Agl mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000033400 Expressed in 289 organ(s), highest expression level in knee joint

Family and domain databases

CDDicd11327 AmyAc_Glg_debranch_2, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR010401 AGL/Gdb1
IPR032788 AGL_central
IPR029436 AGL_euk_N
IPR032792 AGL_glucanoTrfase
IPR032790 GDE_C
IPR006421 Glycogen_debranch_met
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10569 PTHR10569, 1 hit
PfamiView protein in Pfam
PF06202 GDE_C, 1 hit
PF14701 hDGE_amylase, 1 hit
PF14702 hGDE_central, 1 hit
PF14699 hGDE_N, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit
SSF51445 SSF51445, 1 hit
TIGRFAMsiTIGR01531 glyc_debranch, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8VPN4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8VPN4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 18, 2019
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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