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Protein
Submitted name:

Aquaporin-2

Gene

AQP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processTransportUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Aquaporin-2Imported
Gene namesi
Name:AQP2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000167580.7
HGNCiHGNC:634 AQP2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 34HelicalSequence analysisAdd BLAST23
Transmembranei40 – 59HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167580

PTM / Processingi

Proteomic databases

PeptideAtlasiF8VPL3
PRIDEiF8VPL3

Expressioni

Gene expression databases

BgeeiENSG00000167580
ExpressionAtlasiF8VPL3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF8VPL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119223

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 2 hits
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 2 hits
PfamiView protein in Pfam
PF00230 MIP, 2 hits
PRINTSiPR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 2 hits
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

Sequencei

Sequence statusi: Fragment.

F8VPL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWELRSIAFS RAVFAEFLAT LLFVFFGLGS ALNWPQALPS VLQIAMAFGL
60 70 80 90 100
GIGTLVQALG HISGAHINPA VTVACLVGCH VSVLRAAFYV AAQLLGAVAG
110 120 130 140 150
AALLHEITPA DIRGDLAVNA LSNSTTAGQA VTVELFLTLQ LVLCIFASTD
160 170 180 190 200
ERRGENPGTP ALSIGFSVAL GHLLGVGHGH GFQPPWRNRH TDHSRDRHRD
210 220 230 240
PKRDTYTELS RGTDTPEIHY TGCSMNPARS LAPAVVTGKF DDHW
Length:244
Mass (Da):26,056
Last modified:September 21, 2011 - v1
Checksum:i3DF8A78920CFD954
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei244Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025154 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000550862; ENSP00000450022; ENSG00000167580
UCSCiuc058nty.1 human

Similar proteinsi

Entry informationi

Entry nameiF8VPL3_HUMAN
AccessioniPrimary (citable) accession number: F8VPL3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: July 18, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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