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Entry version 78 (29 Sep 2021)
Sequence version 1 (21 Sep 2011)
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Protein
Submitted name:

Regulatory factor X, 7

Gene

Rfx7

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Regulatory factor X, 7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rfx7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2442675, Rfx7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000037674

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
F8VPJ6

PRoteomics IDEntifications database

More...
PRIDEi
F8VPJ6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
343353

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
F8VPJ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000037674, Expressed in pes and 297 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F8VPJ6, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000127192

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F8VPJ6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini108 – 183RFX-type winged-helixInterPro annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni303 – 347DisorderedSequence analysisAdd BLAST45
Regioni404 – 428DisorderedSequence analysisAdd BLAST25
Regioni482 – 590DisorderedSequence analysisAdd BLAST109
Regioni634 – 659DisorderedSequence analysisAdd BLAST26
Regioni688 – 716DisorderedSequence analysisAdd BLAST29
Regioni918 – 1016DisorderedSequence analysisAdd BLAST99

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 19Polar residuesSequence analysisAdd BLAST19
Compositional biasi332 – 347Polar residuesSequence analysisAdd BLAST16
Compositional biasi404 – 418Polar residuesSequence analysisAdd BLAST15
Compositional biasi482 – 534Polar residuesSequence analysisAdd BLAST53
Compositional biasi540 – 554Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi555 – 590Polar residuesSequence analysisAdd BLAST36
Compositional biasi634 – 649Polar residuesSequence analysisAdd BLAST16
Compositional biasi918 – 946Polar residuesSequence analysisAdd BLAST29
Compositional biasi947 – 963Pro residuesSequence analysisAdd BLAST17
Compositional biasi964 – 1016Polar residuesSequence analysisAdd BLAST53

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3712, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00980000198574

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_252972_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCTKSPR

Database of Orthologous Groups

More...
OrthoDBi
67697at2759

TreeFam database of animal gene trees

More...
TreeFami
TF321340

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003150, DNA-bd_RFX
IPR039779, RFX-like
IPR040889, RFX5_N
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12619, PTHR12619, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18326, RFX5_N, 1 hit
PF02257, RFX_DNA_binding, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51526, RFX_DBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F8VPJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEEQQQPPP QQLDAPQQLP LSAPNPGVAL PALVPGLPGT EANALQHKIK
60 70 80 90 100
NSICKTVQSK VDCILQEVEK FTDLEKLYLY LQLPSGLSSA EKSDQNAMSS
110 120 130 140 150
SRAQQMHAFS WIRNTLEEHP ETSLPKQEVY DEYKSYCDNL GYHPLSAADF
160 170 180 190 200
GKIMKNVFPN MKARRLGTRG KSKYCYSGLR KKAFVHMPTL PNLDFHKTGD
210 220 230 240 250
GLEGVEPSGQ LQNIDEEVIS SACRLVCEWA QKVLSQPFDT VLELAHFLVK
260 270 280 290 300
SHYIGTKSMA ALTVMAAAPA GLKGIPQPSA FIPTAESNSF QPQVKTLPSP
310 320 330 340 350
IDAKQQLQRK IQKKQQEQKL QSPLPGESSA KKPEGTTANG VANLPNGNPA
360 370 380 390 400
ILSPQPIGIV VAAVPSPIPV QRTRQLVTSP SPMNSPDGKV LPLNVQVVTQ
410 420 430 440 450
HMQSVKQTPK TPQNVPASPG GDRSARHRYP QILPKPANTS ALTIRSPTTV
460 470 480 490 500
LFTSSPIKTA VVPASHMSSL NVVKMTTISL TPSNSNAPLK HSASVSSATG
510 520 530 540 550
TTEESRIVPQ IKNGSVVSLQ SPGSRASSTG GTSAVEVKME PEGSSDEHPL
560 570 580 590 600
QCQENSEETK APLTTSSALW GQKSNTDGTV PKPSNEGVTE VKTTKVCDQR
610 620 630 640 650
TKCKNRCNEI LSGISAGNNQ STVTLSVATQ NLPFTSTSSP SNGDSVNKDP
660 670 680 690 700
KICTKSPRKR LSATLQESQV PPVKKPIVEQ LSAVTIEGQK PGTVKKDQKV
710 720 730 740 750
PHSGKTESST AGAQIPNKVS ISVSSQIIED QPVNPALVTS EPVLEQQTTP
760 770 780 790 800
SSSPDVKVKL EGSVFLLDRE SKSDGSFNRN EWQQVTKDSD FIAASCEHQQ
810 820 830 840 850
DISVMTIAEH PDIHDLEKSV WELEGMPQDT YSQQLHSQIP ESSLNEIQAQ
860 870 880 890 900
SSDQLPLQSE LKEFESSVSQ TNESYFPFDD ELTQDSIVEE LVLMEQQMSM
910 920 930 940 950
NNSHSYGNCL GMSLQNQSVT PGAPMSSHAS STHFYHPIHS NGTPIHTPTP
960 970 980 990 1000
TPTPTPTPTP TPTPTSEMIA GSQSLSRESP CSRLAQTTPV DSALGSSRHT
1010 1020 1030 1040 1050
PIGTPHSNCS SSVPPSPVEC RNPFAFTPIS SSMAYHDASI VSSSPVKPMQ
1060 1070 1080 1090 1100
RPMATHPDKT KLEWMNNGYG GVGNSSVSGH GILPSYQELV EDRFRKPHAF
1110 1120 1130 1140 1150
AVPGQSYQSQ SRHHDTHFGR LTPVSPVQHQ GATVNTNKQE GFAVPAPLDN
1160 1170 1180 1190 1200
KGTNSSAGSN FRCRSVSPAV HRQRNLSGST LYPVSNIPRS NVTPFGSPVT
1210 1220 1230 1240 1250
PEVHVFTNVH TDACANNIAQ RSQSVPLTVM MQTAFPNALQ KQTNSKKITN
1260 1270 1280 1290 1300
VLLSKLDSDN DDSVRGLGIN NVPSNYTARM NLTQILETSP VFPSANSQNM
1310 1320 1330 1340 1350
IDSSTSVYEF QTPSYLTKSN STDQISFSPG DNQAQSEIGE QQLDFNSTVK
1360 1370 1380 1390 1400
DLLSGDNLQT SQQLVGQVAS DLTNTASDFS SDIRLSSDLS GSINDLNTLD
1410 1420 1430 1440 1450
PNLLFDPGRQ QGQDDEATLE ELKNDPLFQQ ICSESMNSMT SSGFEWIESK

DHPTVEMLG
Length:1,459
Mass (Da):157,638
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AFB7759573D23F4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TDE2Q3TDE2_MOUSE
Regulatory factor X, 7
Rfx7 Rfxdc2
291Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_001028708.1, NM_001033536.1
XP_006511286.1, XM_006511223.3
XP_011241056.1, XM_011242754.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000093820; ENSMUSP00000091338; ENSMUSG00000037674
ENSMUST00000163401; ENSMUSP00000127192; ENSMUSG00000037674

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
319758

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:319758

UCSC genome browser

More...
UCSCi
uc009qqb.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001028708.1, NM_001033536.1
XP_006511286.1, XM_006511223.3
XP_011241056.1, XM_011242754.2

3D structure databases

SMRiF8VPJ6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127192

PTM databases

PhosphoSitePlusiF8VPJ6

Proteomic databases

PeptideAtlasiF8VPJ6
PRIDEiF8VPJ6
ProteomicsDBi343353

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25133, 49 antibodies

The DNASU plasmid repository

More...
DNASUi
319758

Genome annotation databases

EnsembliENSMUST00000093820; ENSMUSP00000091338; ENSMUSG00000037674
ENSMUST00000163401; ENSMUSP00000127192; ENSMUSG00000037674
GeneIDi319758
KEGGimmu:319758
UCSCiuc009qqb.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64864
MGIiMGI:2442675, Rfx7
VEuPathDBiHostDB:ENSMUSG00000037674

Phylogenomic databases

eggNOGiKOG3712, Eukaryota
GeneTreeiENSGT00980000198574
HOGENOMiCLU_252972_0_0_1
OMAiTCTKSPR
OrthoDBi67697at2759
TreeFamiTF321340

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
319758, 0 hits in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rfx7, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000037674, Expressed in pes and 297 other tissues
ExpressionAtlasiF8VPJ6, baseline and differential

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003150, DNA-bd_RFX
IPR039779, RFX-like
IPR040889, RFX5_N
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PANTHERiPTHR12619, PTHR12619, 1 hit
PfamiView protein in Pfam
PF18326, RFX5_N, 1 hit
PF02257, RFX_DNA_binding, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51526, RFX_DBD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8VPJ6_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8VPJ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 29, 2021
This is version 78 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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