UniProtKB - F8VP57 (F8VP57_HUMAN)
Protein
Submitted name:
Ephrin type-A receptor 5
Gene
EPHA5
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:2.7.10.1SAAS annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 708 | ATPUniRule annotation | 1 | |
Active sitei | 801 | Proton acceptorUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 682 – 690 | ATPUniRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ephrin receptor activity Source: InterPro
Keywordsi
Molecular function | Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation |
Ligand | ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Ephrin type-A receptor 5Imported |
Gene namesi | Name:EPHA5Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3389 EPHA5 |
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: InterPro
Keywords - Cellular componenti
MembranePTM / Processingi
Proteomic databases
jPOSTi | F8VP57 |
MaxQBi | F8VP57 |
PeptideAtlasi | F8VP57 |
PRIDEi | F8VP57 |
ProteomicsDBi | 28245 |
Expressioni
Gene expression databases
Bgeei | ENSG00000145242 Expressed in 96 organ(s), highest expression level in frontal cortex |
ExpressionAtlasi | F8VP57 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 60 – 238 | Eph LBDInterPro annotationAdd BLAST | 179 | |
Domaini | 357 – 467 | Fibronectin type-IIIInterPro annotationAdd BLAST | 111 | |
Domaini | 468 – 562 | Fibronectin type-IIIInterPro annotationAdd BLAST | 95 | |
Domaini | 676 – 937 | Protein kinaseInterPro annotationAdd BLAST | 262 | |
Domaini | 966 – 1004 | SAMInterPro annotationAdd BLAST | 39 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Keywords - Domaini
RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotationPhylogenomic databases
eggNOGi | KOG0196 Eukaryota COG0515 LUCA |
GeneTreei | ENSGT00940000156266 |
OrthoDBi | 933071at2759 |
Family and domain databases
CDDi | cd10483 EphR_LBD_A5, 1 hit cd00063 FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.120.260, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936 Eph_TM IPR034277 EphA5_rcpt_lig-bd IPR001090 Ephrin_rcpt_lig-bd_dom IPR003961 FN3_dom IPR036116 FN3_sf IPR008979 Galactose-bd-like_sf IPR009030 Growth_fac_rcpt_cys_sf IPR013783 Ig-like_fold IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001660 SAM IPR013761 SAM/pointed_sf IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR011641 Tyr-kin_ephrin_A/B_rcpt-like IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR016257 Tyr_kinase_ephrin_rcpt IPR001426 Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575 EphA2_TM, 1 hit PF01404 Ephrin_lbd, 1 hit PF00041 fn3, 2 hits PF07714 Pkinase_Tyr, 1 hit PF00536 SAM_1, 1 hit |
PIRSFi | PIRSF000666 TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109 TYRKINASE |
SMARTi | View protein in SMART SM00615 EPH_lbd, 1 hit SM01411 Ephrin_rec_like, 1 hit SM00060 FN3, 2 hits SM00219 TyrKc, 1 hit |
SUPFAMi | SSF47769 SSF47769, 1 hit SSF49265 SSF49265, 1 hit SSF49785 SSF49785, 1 hit SSF56112 SSF56112, 1 hit SSF57184 SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS51550 EPH_LBD, 1 hit PS50853 FN3, 2 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit PS50105 SAM_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
F8VP57-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRGSGPRGAG RRRPPSGGGD TPITPASLAG CYSAPRRAPL WTCLLLCAAL
60 70 80 90 100
RTLLASPSNE VNLLDSRTVM GDLGWIAFPK NGWEEIGEVD ENYAPIHTYQ
110 120 130 140 150
VCKVMEQNQN NWLLTSWISN EGASRIFIEL KFTLRDCNSL PGGLGTCKET
160 170 180 190 200
FNMYYFESDD QNGRNIKENQ YIKIDTIAAD ESFTELDLGD RVMKLNTEVR
210 220 230 240 250
DVGPLSKKGF YLAFQDVGAC IALVSVRVYY KKCPSVVRHL AVFPDTITGA
260 270 280 290 300
DSSQLLEVSG SCVNHSVTDE PPKMHCSAEG EWLVPIGKCM CKAGYEEKNG
310 320 330 340 350
TCQVCRPGFF KASPHIQSCG KCPPHSYTHE EASTSCVCEK DYFRRESDPP
360 370 380 390 400
TMACTRPPSA PRNAISNVNE TSVFLEWIPP ADTGGRKDVS YYIACKKCNS
410 420 430 440 450
HAGVCEECGG HVRYLPRQSG LKNTSVMMVD LLAHTNYTFE IEAVNGVSDL
460 470 480 490 500
SPGARQYVSV NVTTNQAAPS PVTNVKKGKI AKNSISLSWQ EPDRPNGIIL
510 520 530 540 550
EYEIKYFEKD QETSYTIIKS KETTITAEGL KPASVYVFQI RARTAAGYGV
560 570 580 590 600
FSRRFEFETT PVSVAASSDQ SQIPVIAVSV TVGVILLAVV IGVLLSGSCC
610 620 630 640 650
ECGCGRASSL CAVAHPSLIW RCGYSKAKQD PEEEKMHFHN GHIKLPGVRT
660 670 680 690 700
YIDPHTYEDP NQAVHEFAKE IEASCITIER VIGAGEFGEV CSGRLKLPGK
710 720 730 740 750
RELPVAIKTL KVGYTEKQRR DFLGEASIMG QFDHPNIIHL EGVVTKSKPV
760 770 780 790 800
MIVTEYMENG SLDTFLKKND GQFTVIQLVG MLRGISAGMK YLSDMGYVHR
810 820 830 840 850
DLAARNILIN SNLVCKVSDF GLSRVLEDDP EAAYTTRGGK IPIRWTAPEA
860 870 880 890 900
IAFRKFTSAS DVWSYGIVMW EVVSYGERPY WEMTNQDVIK AVEEGYRLPS
910 920 930 940 950
PMDCPAALYQ LMLDCWQKER NSRPKFDEIV NMLDKLIRNP SSLKTLVNAS
960 970 980 990 1000
CRVSNLLAEH SPLGSGAYRS VGEWLEAIKM GRYTEIFMEN GYSSMDAVAQ
VTLE
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP54756 | EPHA5_HUMAN | Ephrin type-A receptor 5 | EPHA5 BSK, EHK1, HEK7, TYRO4 | 1,037 | Annotation score: | ||
B7ZKJ3 | B7ZKJ3_HUMAN | EPH receptor A5 | EPHA5 hCG_1810817 | 1,038 | Annotation score: | ||
B7ZKW7 | B7ZKW7_HUMAN | EPHA5 protein | EPHA5 | 1,016 | Annotation score: | ||
F8W9W0 | F8W9W0_HUMAN | Ephrin type-A receptor 5 | EPHA5 | 874 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018683 Genomic DNA No translation available. AC104137 Genomic DNA No translation available. AC105923 Genomic DNA No translation available. AC115223 Genomic DNA No translation available. |
RefSeqi | NP_001268696.1, NM_001281767.2 |
Genome annotation databases
Ensembli | ENST00000511294; ENSP00000427638; ENSG00000145242 |
GeneIDi | 2044 |
UCSCi | uc003hda.4 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018683 Genomic DNA No translation available. AC104137 Genomic DNA No translation available. AC105923 Genomic DNA No translation available. AC115223 Genomic DNA No translation available. |
RefSeqi | NP_001268696.1, NM_001281767.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
jPOSTi | F8VP57 |
MaxQBi | F8VP57 |
PeptideAtlasi | F8VP57 |
PRIDEi | F8VP57 |
ProteomicsDBi | 28245 |
Genome annotation databases
Ensembli | ENST00000511294; ENSP00000427638; ENSG00000145242 |
GeneIDi | 2044 |
UCSCi | uc003hda.4 human |
Organism-specific databases
CTDi | 2044 |
HGNCi | HGNC:3389 EPHA5 |
OpenTargetsi | ENSG00000145242 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0196 Eukaryota COG0515 LUCA |
GeneTreei | ENSGT00940000156266 |
OrthoDBi | 933071at2759 |
Miscellaneous databases
ChiTaRSi | EPHA5 human |
GenomeRNAii | 2044 |
Gene expression databases
Bgeei | ENSG00000145242 Expressed in 96 organ(s), highest expression level in frontal cortex |
ExpressionAtlasi | F8VP57 baseline and differential |
Family and domain databases
CDDi | cd10483 EphR_LBD_A5, 1 hit cd00063 FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.120.260, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936 Eph_TM IPR034277 EphA5_rcpt_lig-bd IPR001090 Ephrin_rcpt_lig-bd_dom IPR003961 FN3_dom IPR036116 FN3_sf IPR008979 Galactose-bd-like_sf IPR009030 Growth_fac_rcpt_cys_sf IPR013783 Ig-like_fold IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001660 SAM IPR013761 SAM/pointed_sf IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR011641 Tyr-kin_ephrin_A/B_rcpt-like IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR016257 Tyr_kinase_ephrin_rcpt IPR001426 Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575 EphA2_TM, 1 hit PF01404 Ephrin_lbd, 1 hit PF00041 fn3, 2 hits PF07714 Pkinase_Tyr, 1 hit PF00536 SAM_1, 1 hit |
PIRSFi | PIRSF000666 TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109 TYRKINASE |
SMARTi | View protein in SMART SM00615 EPH_lbd, 1 hit SM01411 Ephrin_rec_like, 1 hit SM00060 FN3, 2 hits SM00219 TyrKc, 1 hit |
SUPFAMi | SSF47769 SSF47769, 1 hit SSF49265 SSF49265, 1 hit SSF49785 SSF49785, 1 hit SSF56112 SSF56112, 1 hit SSF57184 SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS51550 EPH_LBD, 1 hit PS50853 FN3, 2 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit PS50105 SAM_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F8VP57_HUMAN | |
Accessioni | F8VP57Primary (citable) accession number: F8VP57 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | September 21, 2011 | |
Last modified: | July 31, 2019 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |