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UniProtKB - F8S0F2 (F8S0F2_HUMAN)
Protein
Submitted name:
Broad substrate-specificity ATP-binding cassette transporter ABCG2
Gene
ABCG2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATPase-coupled transmembrane transporter activity Source: InterPro
- ATP binding Source: UniProtKB-KW
Keywordsi
Biological process | TransportARBA annotation |
Ligand | ATP-bindingImported, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Broad substrate-specificity ATP-binding cassette transporter ABCG2ImportedSubmitted name: Multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2Imported |
Gene namesi | Name:ABCG2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:74, ABCG2 |
VEuPathDBi | HostDB:ENSG00000118777 |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: UniProtKB-KW
Other locations
- integral component of membrane Source: InterPro
Keywords - Cellular componenti
Cell membraneARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000118777, Expressed in jejunal mucosa and 205 other tissues |
ExpressionAtlasi | F8S0F2, baseline and differential |
Family & Domainsi
Phylogenomic databases
GeneTreei | ENSGT00940000162658 |
HOGENOMi | CLU_1942891_0_0_1 |
OMAi | WCARMSS |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR030256, ABCG2 IPR027417, P-loop_NTPase |
PANTHERi | PTHR48041:SF92, PTHR48041:SF92, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F8S0F2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSSNVEVFI PVSQGNTNGF PATASNDLKA FTEGAVLSFH NICYRVKLKS
60 70 80 90 100
GFLPCRKPVE KEILSNINGI MKPGLNAILG PTGGGKSSLL DVLAARKDPS
110
GLSGDVLING AP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ9UNQ0 | ABCG2_HUMAN | Broad substrate specificity ATP-bin... | ABCG2 ABCP, BCRP, BCRP1, MXR | 655 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 112 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC084732 Genomic DNA No translation available. AC097484 Genomic DNA No translation available. HQ386990 mRNA Translation: ADO95109.1 HQ386991 mRNA Translation: ADO95110.1 HQ386992 mRNA Translation: ADO95111.1 HQ386993 mRNA Translation: ADO95112.1 HQ386994 mRNA Translation: ADO95113.1 HQ386995 mRNA Translation: ADO95114.1 HQ386996 mRNA Translation: ADO95115.1 HQ386997 mRNA Translation: ADO95116.1 HQ386998 mRNA Translation: ADO95117.1 HQ386999 mRNA Translation: ADO95118.1 HQ387000 mRNA Translation: ADO95119.1 HQ387001 mRNA Translation: ADO95120.1 HQ387002 mRNA Translation: ADO95121.1 HQ387003 mRNA Translation: ADO95122.1 HQ387004 mRNA Translation: ADO95123.1 HQ387005 mRNA Translation: ADO95124.1 |
Genome annotation databases
Ensembli | ENST00000503830; ENSP00000426934; ENSG00000118777 ENST00000505480; ENSP00000426916; ENSG00000118777 |
UCSCi | uc062ych.1, human uc062yci.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC084732 Genomic DNA No translation available. AC097484 Genomic DNA No translation available. HQ386990 mRNA Translation: ADO95109.1 HQ386991 mRNA Translation: ADO95110.1 HQ386992 mRNA Translation: ADO95111.1 HQ386993 mRNA Translation: ADO95112.1 HQ386994 mRNA Translation: ADO95113.1 HQ386995 mRNA Translation: ADO95114.1 HQ386996 mRNA Translation: ADO95115.1 HQ386997 mRNA Translation: ADO95116.1 HQ386998 mRNA Translation: ADO95117.1 HQ386999 mRNA Translation: ADO95118.1 HQ387000 mRNA Translation: ADO95119.1 HQ387001 mRNA Translation: ADO95120.1 HQ387002 mRNA Translation: ADO95121.1 HQ387003 mRNA Translation: ADO95122.1 HQ387004 mRNA Translation: ADO95123.1 HQ387005 mRNA Translation: ADO95124.1 |
3D structure databases
SMRi | F8S0F2 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | F8S0F2 |
ProteomicsDBi | 36355 36357 |
Protocols and materials databases
Antibodypediai | 14577, 368 antibodies from 45 providers |
Genome annotation databases
Ensembli | ENST00000503830; ENSP00000426934; ENSG00000118777 ENST00000505480; ENSP00000426916; ENSG00000118777 |
UCSCi | uc062ych.1, human uc062yci.1, human |
Organism-specific databases
HGNCi | HGNC:74, ABCG2 |
OpenTargetsi | ENSG00000118777 |
VEuPathDBi | HostDB:ENSG00000118777 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000162658 |
HOGENOMi | CLU_1942891_0_0_1 |
OMAi | WCARMSS |
Miscellaneous databases
ChiTaRSi | ABCG2, human |
Gene expression databases
Bgeei | ENSG00000118777, Expressed in jejunal mucosa and 205 other tissues |
ExpressionAtlasi | F8S0F2, baseline and differential |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR030256, ABCG2 IPR027417, P-loop_NTPase |
PANTHERi | PTHR48041:SF92, PTHR48041:SF92, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F8S0F2_HUMAN | |
Accessioni | F8S0F2Primary (citable) accession number: F8S0F2 Secondary accession number(s): H0YAF1, H0YAF3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | September 21, 2011 | |
Last modified: | January 19, 2022 | |
This is version 54 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |