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Entry version 44 (05 Jun 2019)
Sequence version 1 (21 Sep 2011)
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Protein
Submitted name:

LIM domain only 7 protein

Gene

LMO7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LIM domain only 7 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LMO7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
F8J2B5

PRoteomics IDEntifications database

More...
PRIDEi
F8J2B5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 129Calponin-homology (CH)InterPro annotationAdd BLAST118
Domaini990 – 1066PDZInterPro annotationAdd BLAST77
Domaini1560 – 1626LIM zinc-bindingInterPro annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni260 – 291DisorderedSequence analysisAdd BLAST32
Regioni697 – 849DisorderedSequence analysisAdd BLAST153
Regioni895 – 985DisorderedSequence analysisAdd BLAST91
Regioni1203 – 1552DisorderedSequence analysisAdd BLAST350

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi276 – 291PolyampholyteSequence analysisAdd BLAST16
Compositional biasi697 – 737PolyampholyteSequence analysisAdd BLAST41
Compositional biasi775 – 807PolyampholyteSequence analysisAdd BLAST33
Compositional biasi808 – 849PolarSequence analysisAdd BLAST42
Compositional biasi897 – 925PolarSequence analysisAdd BLAST29
Compositional biasi932 – 965PolarSequence analysisAdd BLAST34
Compositional biasi1203 – 1224PolyampholyteSequence analysisAdd BLAST22
Compositional biasi1226 – 1253PolarSequence analysisAdd BLAST28
Compositional biasi1254 – 1340PolyampholyteSequence analysisAdd BLAST87
Compositional biasi1376 – 1404PolarSequence analysisAdd BLAST29
Compositional biasi1417 – 1431PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1462 – 1552PolarSequence analysisAdd BLAST91

Keywords - Domaini

LIM domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1704 Eukaryota
ENOG410XP0W LUCA

KEGG Orthology (KO)

More...
KOi
K06084

Database of Orthologous Groups

More...
OrthoDBi
38375at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR031865 DUF4757
IPR029978 LMO-7
IPR001478 PDZ
IPR036034 PDZ_sf
IPR003096 SM22_calponin
IPR001781 Znf_LIM

The PANTHER Classification System

More...
PANTHERi
PTHR46767 PTHR46767, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 1 hit
PF15949 DUF4757, 2 hits
PF00412 LIM, 1 hit
PF00595 PDZ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00888 SM22CALPONIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F8J2B5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGLEEAEAN CSVAFAEAQR WVEAVTEKNF ETKDFRASLE NGVLLCDLIN
60 70 80 90 100
KLKPGVIKKI NRLSTPIAGL DNINVFLKAC EQIGLKEAQL FHPGDLQDLS
110 120 130 140 150
NRVTVKQEET DRRVKNVLIT LYWLGRKAQS NPYYNGPHLN LKAFENLLGQ
160 170 180 190 200
ALTKALEDSS FLKRSGRDSG YGDIWCPERG EFLAPPRHHK REDSFESLDS
210 220 230 240 250
LGSRSLTSCS SDITLRGGRE GFESDTDSEF TFKMQDYNKD DMSYRRISAV
260 270 280 290 300
EPKTALPFNR FLPNKSRQPS YVPAPLRKKK PDKHEDNRRS WASPVYTEAD
310 320 330 340 350
GTFSSNQRRI WGTNVENWPT VQGTSKSSCY LEEEKAKTRS IPNIVKDDLY
360 370 380 390 400
VRKLSPVMPN PGNAFDQFLP KCWTPEDVNW KRIKRETYKP WYKEFQGFSQ
410 420 430 440 450
FLLLQALQTY SDDILSSETH TKIDPTSGPR LITRRKNLSY APGYRRDDLE
460 470 480 490 500
MAALDPDLEN DDFFVRKTGV FHANPYVLRA FEDFRKFSEQ DDSVERDIIL
510 520 530 540 550
QCREGELVLP DLEKDDMIVR RIPAQKKEVP LSGAPDRYHP VPFPEPWTLP
560 570 580 590 600
PEIQAKFLCV FERTCPSKEK SNSCRILVPS YRQKKDDMLT RKIQSWKLGT
610 620 630 640 650
TVPPISFTPG PCSEADLKRW EAIREASRLR HKKRLMVERL FQKIYGENGS
660 670 680 690 700
KSMSDVSAED VQNLRQLRYE EMQKIKSQLK EQDQKWQDDL AKWKDRRKSY
710 720 730 740 750
TSDLQKKKEE REEIEKQALE KSKRSSKTFK EMLQDRESQN QKSTVPSRRR
760 770 780 790 800
MYSFDDVLEE GKRPPTMTVS EASYQSERVE EKGATYPSEI PKEDSTTFAK
810 820 830 840 850
REDRVTTEIQ LPSQSPVEEQ SPASLSSLRS RSTQMESTRV SASLPRSYRK
860 870 880 890 900
TDTVRLTSVV TPRPFGSQTR GISSLPRSYT MDDAWKYNGD VEDIKRTPNN
910 920 930 940 950
VVSTPAPSPD ASQLASSLSS QKEVAATEED VTRLPSPTSP FSSLSQDQAA
960 970 980 990 1000
TSKATLSSTS GLDLMSESGE GEISPQREVS RSQDQFSDMR ISINQTPGKS
1010 1020 1030 1040 1050
LDFGFTIKWD IPGIFVASVE AGSPAEFSQL QVDDEIIAIN NTKFSYNDSK
1060 1070 1080 1090 1100
EWEEAMAKAQ ETGHLVMDVR RYGKAGSPET KWIDATSGIY NSEKSSNLSV
1110 1120 1130 1140 1150
TTDFSESLQS SNIESKEING IHDESNAFES KASESISLKN LKRRSQFFEQ
1160 1170 1180 1190 1200
GSSDSVVPDL PVPTISAPSR WVWDQEEERK RQERWQKEQD RLLQEKYQRE
1210 1220 1230 1240 1250
QEKLREEWQR AKQEAERENS KYLDEELMVL SSNSMSLTTR EPSLATWEAT
1260 1270 1280 1290 1300
WSEGSKSSDR EGTRAGEEER RQPQEEVVHE DQGKKPQDQL VIERERKWEQ
1310 1320 1330 1340 1350
QLQEEQEQKR LQAEAEEQKR PAEEQKRQAE IERETSVRIY QYRRPVDSYD
1360 1370 1380 1390 1400
IPKTEEASSG FLPGDRNKSR STTELDDYST NKNGNNKYLD QIGNMTSSQR
1410 1420 1430 1440 1450
RSKKEQVPSG AELERQQILQ EMRKRTPLHN DNSWIRQRSA SVNKEPVSLP
1460 1470 1480 1490 1500
GIMRRGESLD NLDSPRSNSW RQPPWLNQPT GFYASSSVQD FSRPPPQLVS
1510 1520 1530 1540 1550
TSNRAYMRNP SSSVPPPSAG SVKTSTTGVA TTQSPTPRSH SPSASQSGSQ
1560 1570 1580 1590 1600
LRNRSVSGKR ICSYCNNILG KGAAMIIESL GLCYHLHCFK CVACECDLGG
1610 1620 1630
SSSGAEVRIR NHQLYCNDCY LRFKSGRPTA M
Length:1,631
Mass (Da):186,241
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FC1483913806856
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FJ711162 mRNA Translation: ACV60543.1

NCBI Reference Sequences

More...
RefSeqi
NP_001293009.1, NM_001306080.1
NP_001317512.1, NM_001330583.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4008

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4008

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ711162 mRNA Translation: ACV60543.1
RefSeqiNP_001293009.1, NM_001306080.1
NP_001317512.1, NM_001330583.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiF8J2B5
PRIDEiF8J2B5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4008
KEGGihsa:4008

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4008

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410XP0W LUCA
KOiK06084
OrthoDBi38375at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LMO7 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4008

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR031865 DUF4757
IPR029978 LMO-7
IPR001478 PDZ
IPR036034 PDZ_sf
IPR003096 SM22_calponin
IPR001781 Znf_LIM
PANTHERiPTHR46767 PTHR46767, 1 hit
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF15949 DUF4757, 2 hits
PF00412 LIM, 1 hit
PF00595 PDZ, 1 hit
PRINTSiPR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8J2B5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8J2B5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 5, 2019
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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