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Entry version 48 (02 Jun 2021)
Sequence version 1 (21 Sep 2011)
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Protein
Submitted name:

Permease for cytosine/purines uracil thiamine allantoin

Gene

TC41_2961

Organism
Alicyclobacillus acidocaldarius (strain Tc-4-1) (Bacillus acidocaldarius)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransportUniRule annotation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
AACI1048834:G1GZ5-2794-MONOMER

Protein family/group databases

Transport Classification Database

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TCDBi
2.A.39.1.4, the nucleobase:cation symporter-1 (ncs1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Permease for cytosine/purines uracil thiamine allantoinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:TC41_2961Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAlicyclobacillus acidocaldarius (strain Tc-4-1) (Bacillus acidocaldarius)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1048834 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesAlicyclobacillaceaeAlicyclobacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000292 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei71 – 92HelicalSequence analysisAdd BLAST22
Transmembranei113 – 138HelicalSequence analysisAdd BLAST26
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Transmembranei182 – 199HelicalSequence analysisAdd BLAST18
Transmembranei219 – 238HelicalSequence analysisAdd BLAST20
Transmembranei258 – 283HelicalSequence analysisAdd BLAST26
Transmembranei303 – 322HelicalSequence analysisAdd BLAST20
Transmembranei342 – 360HelicalSequence analysisAdd BLAST19
Transmembranei372 – 389HelicalSequence analysisAdd BLAST18
Transmembranei422 – 444HelicalSequence analysisAdd BLAST23
Transmembranei456 – 474HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
1048834.TC41_2961

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the purine-cytosine permease (2.A.39) family.UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1457, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026016_3_2_9

Identification of Orthologs from Complete Genome Data

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OMAi
MYSAGFT

Database of Orthologous Groups

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OrthoDBi
326558at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.4160.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001248, Pur-cyt_permease
IPR026030, Pur-cyt_permease_Fcy2/21/22
IPR038271, Pur-cyt_permease_sf

The PANTHER Classification System

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PANTHERi
PTHR31806, PTHR31806, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02133, Transp_cyt_pur, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002744, Pur-cyt_permease, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F8IKT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATADELRHT AQVDEAFRLE TEGNGIIAEH RRHGMPRELF YVWFAAVLTF
60 70 80 90 100
TGVVTGQLFT GVFGLNVWES LLIVLLCSIS FAALGLYVAT GPRAGTVTLT
110 120 130 140 150
ISRAAFGVHG GKIPAFFSWF TAVGWESVTM VLTVWAMLSL AQYVGLPSTG
160 170 180 190 200
VGPTLVALVI TLFLTYLVPI LGHATLVVMQ RVLAIVLAAC TVLVLFAVLP
210 220 230 240 250
DVKWNFNPPA SALAAHGVFP TFLLALSVGL ASTFYGWANF AADYSRYLPK
260 270 280 290 300
ETKTSRMVWA TFLGGGLANF IMMGLGVVLG TVISAKAFSA NPVMAIAKAI
310 320 330 340 350
PEWAAIPFLI VVVLGDICAN YLNAYSSGMS FLSMGIRLKR HFAVALDGAI
360 370 380 390 400
CTAIGIYALF FSNNFVDFFE NFLDLMITVM GPWAAIYIVH HFAVRGRYAA
410 420 430 440 450
DDLVDASPTS AYWYNGGFNW RAIVAFVVGA VATFLSVNSA LWQSPLTNAW
460 470 480 490
FGGADVSAYA APIVTGLVYL LLIAPRRERV KAPKAEVKAS
Length:490
Mass (Da):52,777
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31D4F652972A503F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP002902 Genomic DNA Translation: AEJ44850.1

NCBI Reference Sequences

More...
RefSeqi
WP_014465671.1, NC_017167.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AEJ44850; AEJ44850; TC41_2961

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
aad:TC41_2961

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1048834.4.peg.2813

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002902 Genomic DNA Translation: AEJ44850.1
RefSeqiWP_014465671.1, NC_017167.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi1048834.TC41_2961

Protein family/group databases

TCDBi2.A.39.1.4, the nucleobase:cation symporter-1 (ncs1) family

Genome annotation databases

EnsemblBacteriaiAEJ44850; AEJ44850; TC41_2961
KEGGiaad:TC41_2961
PATRICifig|1048834.4.peg.2813

Phylogenomic databases

eggNOGiCOG1457, Bacteria
HOGENOMiCLU_026016_3_2_9
OMAiMYSAGFT
OrthoDBi326558at2

Enzyme and pathway databases

BioCyciAACI1048834:G1GZ5-2794-MONOMER

Family and domain databases

Gene3Di1.10.4160.10, 1 hit
InterProiView protein in InterPro
IPR001248, Pur-cyt_permease
IPR026030, Pur-cyt_permease_Fcy2/21/22
IPR038271, Pur-cyt_permease_sf
PANTHERiPTHR31806, PTHR31806, 1 hit
PfamiView protein in Pfam
PF02133, Transp_cyt_pur, 1 hit
PIRSFiPIRSF002744, Pur-cyt_permease, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8IKT4_ALIAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8IKT4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 2, 2021
This is version 48 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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