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Protein
Submitted name:

Polyketide synthase modules-related protein

Gene

F7308_0744

Organism
Francisella sp. (strain TX077308)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
FSP573569:G1GYT-752-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Polyketide synthase modules-related proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:F7308_0744Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFrancisella sp. (strain TX077308)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri573569 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000490 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2242O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
573569.F7308_0744

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2205 – 2283CarrierInterPro annotationAdd BLAST79

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4107EEY Bacteria
COG3321 LUCA

Database of Orthologous Groups

More...
OrthoDBi
POG091H06Z6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR016039 Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF08240 ADH_N, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF00550 PP-binding, 1 hit
PF14765 PS-DH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827 PKS_AT, 1 hit
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 1 hit
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 2 hits
SSF52151 SSF52151, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F8GB63-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKVAIIGYS FVLPEGIDSD KDLWEALEQG QDLVSEIPDS RFDKRKFFHP
60 70 80 90 100
SRKKSGKSYT FSAGILPNID QFDPSLFNIS SREANQIDPQ QRLLLNHTYF
110 120 130 140 150
ALQKAGYSPE QFSGCNCGVY IGASNIDYTY FAVEDCHEMT SYAMTGGAKS
160 170 180 190 200
IIANRISYSF NLKGSSMVVD TACSSSLVAL DLAVKAIQSG QQDTAIVGGV
210 220 230 240 250
NALLHPMAFV GFSKAYMMSP TGRCRSFSED ADGYVRSEGC IVFVIKDYEK
260 270 280 290 300
AIKDGDTIYG LINKTGANSD GKTSGLPLPS FEAQRDLLNE IYSDTDLNKI
310 320 330 340 350
VYLEAHGTGT PVGDPLEIQA IAEAVSLKRK NHLITGSIKS NIGHLEPASG
360 370 380 390 400
LAGVLKSLMI FEHKKVPANI HFDKPNPKLN LETNNIIISN ETIPIEITSE
410 420 430 440 450
SLIGVNSFGF GGTNAHVLLQ APPSGISATK KYSDNKYFHN SLIIKSHSAI
460 470 480 490 500
TLEKQRQIQA NIIDSEDTYN KYALASKINR GYKDFYAIYN SFEDFQKNKG
510 520 530 540 550
QDYEIDFEAQ KVAFVFSGNG CQYPGMLRIL NNSKELKSYF KSIIDELFVI
560 570 580 590 600
SQRSLEDWLL IDQESYDDTT IAQPALFIFQ VTIARYLLES GLKITNVLGH
610 620 630 640 650
SIGELAAAYI SGNIALNEAY QLVVARSQAQ ATTKGQGSML AINVSIDDFK
660 670 680 690 700
DLTTELSLQN LDIAAINTND SLTIAGEYKK LEALKDHCEK QQIFCRLLDV
710 720 730 740 750
DYPFHSSFMN DSVKDLFLQK LPKFDSSFTN KNIEFISTVL GKNIESEQLR
760 770 780 790 800
SSEYWWDNIA KPVNFSAGIE NLISNDVDVL IETSPKSVLK YYINQISQKS
810 820 830 840 850
KSTYFGTVEN NKLVLNEIAQ RLYLAGAPWQ NEVVESENVP LTRSELNLQK
860 870 880 890 900
YWFHTSDRVI TSEVDHILLG WRISNKSNTW VNHIDYQTAI DFQGHQVHGV
910 920 930 940 950
AVLPASAWIE MAYQLIKHVK ELESTDVVIL KDIQILSPLL LQEDDMRTVI
960 970 980 990 1000
STCDDNGILT IKSLSQYGEN EVVHIKSRYL LKNVISTFNL PSESSTSLHD
1010 1020 1030 1040 1050
FSIEDHYTNA KAVGLNYTDN FRIIDQLKLF ENKAVACFNS NIKSNNYTLS
1060 1070 1080 1090 1100
PFALDGGFQT IFSLIYKDGD QDIALPVGFD FVNIINPCGK IQRVFTELSY
1110 1120 1130 1140 1150
RNDYIAIANF YFFDDENNIV SFIKGAKFEK VAGTHSNLQL KECYIESLQP
1160 1170 1180 1190 1200
IALVEQNYHF KPVLSPKISQ NNELINQEEK IILSFTRLLL VNQAYQQYLE
1210 1220 1230 1240 1250
NNNISFSEEM MMLMQSYLDE DGSWENTNFI DEIHEILQLA FVEHPNLVKL
1260 1270 1280 1290 1300
LLRLYTKSID MNLDTLQVND SIDVIESLWQ SYFGQAIKQE VRAVIDALHQ
1310 1320 1330 1340 1350
GYENKETPLR ILVVGDGLYN EALQQLDNCS IDAITFRNGW ADLYEEYKSY
1360 1370 1380 1390 1400
YDCLLIESVP TFAKKDFVDL LMDKLKPGGV VKLHLWLDSI EVRFLINILK
1410 1420 1430 1440 1450
PKIKCVRKNV IADFIKQAEN RESQLSSNAF IQELLLQKDW QYTSKHVEST
1460 1470 1480 1490 1500
NLECQLYHYG RRLKNVFDKQ GVGLPIVFTI GKDVKEQDLW DIIRKVYKTS
1510 1520 1530 1540 1550
GEEIYVIIES QFHNKILISP VHQSFLATLR VIVNEKPSVS ITRVVIDDFD
1560 1570 1580 1590 1600
SQQDWSAIFD ECNKNQELFV KDNTLYNHAI IPLDNTNLSQ EYKLHITHRG
1610 1620 1630 1640 1650
SFNNLQWLVK EASVSVCGQQ DVRVKVYYTG LNFRDVMYAL GLIPQESLEF
1660 1670 1680 1690 1700
GYLGAYLGME FSGEVVEVGR GVSQFKVGDK VFGCARQSFS TELVVDSNFI
1710 1720 1730 1740 1750
SHLPKHSSMQ QGATISVAFM TAYYAINKVA KAQSGQKILI HGAAGAIGLA
1760 1770 1780 1790 1800
AIQVAHLLEL EIHATVGSKQ KRILLESLGV ENIYDSRSTD FFMQMNQNEI
1810 1820 1830 1840 1850
QMDIVLNSLS SDLLEASLAV LAPFGHFIEL GKRDIFENNT LAMKVFRNNI
1860 1870 1880 1890 1900
TFSGIDLDQL IKYKPQVIKQ MLSELKQYLD EQDFVALPYQ EFPMHKIESA
1910 1920 1930 1940 1950
FRYMQQGQQL GKVIVNMQQK DFIKLDQWSS EFATVKGAYL ITGGTQGFGF
1960 1970 1980 1990 2000
YTAKELAKHG AEHLILVSYS GKITSENKKQ LDELGITYEV HAVDVSKESG
2010 2020 2030 2040 2050
VKEFLQNLYQ DGVDLQGIIH AAVVYDDQAL DTLTKDSFDK VFDVKALGGL
2060 2070 2080 2090 2100
WLDKFSRVWD LKHFIVFSSI ATTVGNLHQA NYVAANAYLE GVMAKRQFEG
2110 2120 2130 2140 2150
LSGQYIAWGP IADVGLLTRN ESLKQVMSGS LGLVPLSLLD CKNVLNQALS
2160 2170 2180 2190 2200
NSEQSFIATK LEGNKLLKAL PILKTSRYHQ FIQDSESEII GSLNADMLRE
2210 2220 2230 2240 2250
LSKDESQALV EDNVASQVAH ILGISKSALD ISADLKELGM DSLMAFELAV
2260 2270 2280 2290 2300
NLEEKFTGVS IPAMSMTQLK TSQDIVNMIM RNVYGNDENQ DVNDVIQIIK

QRHGEE
Length:2,306
Mass (Da):259,442
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7090CF3A1AE3C2F9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP002872 Genomic DNA Translation: AEI35671.1

NCBI Reference Sequences

More...
RefSeqi
WP_013922511.1, NC_015696.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AEI35671; AEI35671; F7308_0744

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
frt:F7308_0744

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002872 Genomic DNA Translation: AEI35671.1
RefSeqiWP_013922511.1, NC_015696.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi573569.F7308_0744

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEI35671; AEI35671; F7308_0744
KEGGifrt:F7308_0744

Phylogenomic databases

eggNOGiENOG4107EEY Bacteria
COG3321 LUCA
OrthoDBiPOG091H06Z6

Enzyme and pathway databases

BioCyciFSP573569:G1GYT-752-MONOMER

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF08240 ADH_N, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF00550 PP-binding, 1 hit
PF14765 PS-DH, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 2 hits
SSF52151 SSF52151, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF8GB63_FRAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F8GB63
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 7, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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