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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Treponema paraluiscuniculi (strain Cuniculi A)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi125ZincUniRule annotation1
Metal bindingi127ZincUniRule annotation1
Metal bindingi152ZincUniRule annotation1
Metal bindingi154ZincUniRule annotation1
Binding sitei273ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciTPAR545776:G1GYH-691-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotationImported
Ordered Locus Names:TPCCA_0673Imported
OrganismiTreponema paraluiscuniculi (strain Cuniculi A)Imported
Taxonomic identifieri545776 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000008317 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 339tRNA-synt_1cInterPro annotationAdd BLAST338

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi270 – 274"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

KOiK01885
OMAiAYYAFDT

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit

Sequencei

Sequence statusi: Complete.

F7XTA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVRVRYAPS PTGLQHIGGI RTALFNFLFA RAHAGVFVLR VEDTDRSRCT
60 70 80 90 100
AAFEQNLYDT LRWLGVSWDE GGGCPETAVK QGARGDGRSV AHAGGAYGPY
110 120 130 140 150
TQSARTDLYR AQVARLVETG QAYYCFCDAS RLERVRKIRT LNRMPPGYDR
160 170 180 190 200
HCRELLPEEV RECLASGVPH VIRFKVPLEG STHFRDALLG DIEWQNEEIN
210 220 230 240 250
PDPILLKSDG FPTYHLANVV DDHAMRITHV LRAQEWVPST PLHLLLYRAF
260 270 280 290 300
GWQPPLFCHL PMVMGADGHK LSKRHGATSC DEFRNAGYLP EALLNYVAML
310 320 330 340 350
GCSYGEGQDL FTREQLCAHF SLSRLNKSPA VFDYKKLAWF NGQYIRAKSD
360 370 380 390 400
EQLCALVWPF IANAGVCGHI PADVEAEAVR TRRFADEAPC APTEAQRSML
410 420 430 440 450
MRVIPLIKER LRFLTDAPEL VRCFFQEPSL PEQGVFVPKR LDVAQVRAVL
460 470 480 490 500
VRARGLVHEI VSASEPDVEV LLRAEAEKFG IKLGDFLMPI RVALTGATVS
510 520 530
APLVGTIRIL GASRSCARIE HVIRERFSDD SQGVGGG
Length:537
Mass (Da):59,912
Last modified:September 21, 2011 - v1
Checksum:i9643E4DA12DAE029
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002103 Genomic DNA Translation: AEH40603.1
RefSeqiWP_013945285.1, NC_015714.1

Genome annotation databases

EnsemblBacteriaiAEH40603; AEH40603; TPCCA_0673
KEGGitpl:TPCCA_0673
PATRICifig|545776.3.peg.673

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002103 Genomic DNA Translation: AEH40603.1
RefSeqiWP_013945285.1, NC_015714.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEH40603; AEH40603; TPCCA_0673
KEGGitpl:TPCCA_0673
PATRICifig|545776.3.peg.673

Phylogenomic databases

KOiK01885
OMAiAYYAFDT

Enzyme and pathway databases

BioCyciTPAR545776:G1GYH-691-MONOMER

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF7XTA0_TREPU
AccessioniPrimary (citable) accession number: F7XTA0
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 7, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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