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Protein

Protein GrpE

Gene

grpE

Organism
Sinorhizobium meliloti (strain SM11)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperoneUniRule annotationSAAS annotation
Biological processStress responseUniRule annotationSAAS annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpEUniRule annotation
Alternative name(s):
HSP-70 cofactorUniRule annotation
Gene namesi
Name:grpEUniRule annotationImported
Ordered Locus Names:SM11_chr0011Imported
OrganismiSinorhizobium meliloti (strain SM11)Imported
Taxonomic identifieri707241 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000009045 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliF7X5T1
SMRiF7X5T1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili42 – 69Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the GrpE family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK03687
OMAiYAYEKIA
OrthoDBiPOG091H00J8

Family and domain databases

CDDicd00446 GrpE, 1 hit
Gene3Di2.30.22.10, 1 hit
3.90.20.20, 1 hit
HAMAPiMF_01151 GrpE, 1 hit
InterProiView protein in InterPro
IPR000740 GrpE
IPR013805 GrpE_coiled_coil
IPR009012 GrpE_head
PANTHERiPTHR21237 PTHR21237, 1 hit
PfamiView protein in Pfam
PF01025 GrpE, 1 hit
PRINTSiPR00773 GRPEPROTEIN
SUPFAMiSSF51064 SSF51064, 1 hit
SSF58014 SSF58014, 1 hit
PROSITEiView protein in PROSITE
PS01071 GRPE, 1 hit

Sequencei

Sequence statusi: Complete.

F7X5T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDETNKNGP EAAAPEEFET AAEPQAAEKP EADASTTAPD PLELARAESA
60 70 80 90 100
ELRDKYLRLA AEMDNLRRRT ERDVKDAKSY SVAGFARDML AVSDNLRRAL
110 120 130 140 150
DAIPADAREA GDAGLKALIE GVEMTERSML AALERHGVKQ LDPTGQKFDP
160 170 180 190 200
NFHQAMFEVP NTEVPNNTVV QVVQAGYTIG ERVLRPAMVG VAKGGPKAAT

SESETPAA
Length:208
Mass (Da):22,362
Last modified:September 21, 2011 - v1
Checksum:iBCCEDA60FCF2F162
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001830 Genomic DNA Translation: AEH77299.1
RefSeqiWP_003527728.1, NC_017325.1

Genome annotation databases

EnsemblBacteriaiAEH77299; AEH77299; SM11_chr0011
KEGGismx:SM11_chr0011
PATRICifig|707241.3.peg.11

Similar proteinsi

Entry informationi

Entry nameiF7X5T1_SINMM
AccessioniPrimary (citable) accession number: F7X5T1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 28, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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