PRNP

Functionⁱ

Miscellaneous

This protein is produced by a bicistronic gene which also produces the major prion protein/PRNP from an overlapping reading frame.1 Publication

The alternative prion protein/AltPrP and PRNP (AC P04156) have no apparent direct functional relation since a mutation that removes the start codon of the AltPrP has no apparent effect on the biology of PRNP. In mouse and hamster, the alternative initiation AUG codon is absent and is replaced by a GUG codon (PubMed:21478263).1 Publication

Enzyme and pathway databases

SIGNORⁱ	F7VJQ1

SIGNORⁱ

F7VJQ1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alternative prion protein Alternative name(s): AltPrP
Gene namesⁱ	Name:PRNP Synonyms:ALTPRP, PRIP, PRP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Unplaced

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9449 PRNP
neXtProtⁱ	NX_F7VJQ1

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	32 – 52	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5621
GeneReviewsⁱ	PRNP
MalaCards human disease database More...MalaCardsⁱ	PRNP

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000420424	1 – 73	Alternative prion proteinAdd BLAST		73

Proteomic databases

PRIDEⁱ	F7VJQ1

PRIDEⁱ

F7VJQ1

PTM databases

SwissPalmⁱ	F7VJQ1

SwissPalmⁱ

F7VJQ1

Expressionⁱ

Tissue specificityⁱ

Detected in brain homogenate, primary neurons, and peripheral blood mononuclear cells (at protein level).1 Publication

Inductionⁱ

Up-regulated by endoplasmic reticulum stress and proteasomal inhibition.1 Publication

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	111606, 72 interactors

BioGridⁱ

111606, 72 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	F7VJQ1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	25 – 64	Trp-richAdd BLAST		40

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative initiation. Align Add to basket

Isoform 3 (identifier: F7VJQ1-1) [UniParc]FASTA Add to basket

Also known as: AltPrP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEHWGQPIPG AGQPWRQPLP TSGRWWLGAA SWWWLGAASW WWLGAAPWWW 
        60         70 
LGTASWWWLG SRRWHPQSVE QAE

Length:73

Mass (Da):8,691

Last modified:September 21, 2011 - v1

Checksum:ⁱ4360C28341A4CA52

GO

Isoform 1 (identifier: P04156-1) [UniParc]FASTA Add to basket

Also known as: PrP

The sequence of this isoform can be found in the external entry P04156.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:253

Mass (Da):27,661

GO

Isoform 2 (identifier: P04156-2) [UniParc]FASTA Add to basket

Also known as: PrP(M8)

The sequence of this isoform can be found in the external entry P04156.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:246

Mass (Da):26,885

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL133396 Genomic DNA No translation available. BK007887 Genomic DNA Translation: DAA34790.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001258490.1, NM_001271561.2 [F7VJQ1-1]
UniGeneⁱ	Hs.472010 Hs.610285 Hs.721670

Genome annotation databases

GeneIDⁱ	5621

GeneIDⁱ

5621

Keywords - Coding sequence diversityⁱ

Alternative initiation

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
F7VJQ1	Alternative prion protein		HUMAN		73	UniRef90_F7VJQ1
P04156-2	Major prion protein	)	HUMAN		253	UniRef90_P04156
Major prion protein		SAISC		260
Major prion protein	)	FELCA		256
Major prion protein		MOSCH		256
Major prion protein	)	ODOHE		256
+409

Protein	Similar proteins		Species	Score	Length	Source
F7VJQ1	Alternative prion protein		SHEEP		64	UniRef50_F7VJQ1
Alternative prion protein		BOVIN		81
Alternative prion protein		HUMAN		73
Alternative prion protein		ODOVR		73
Alternative prion protein		ODOVR		73
+2
P04156-2	Major prion protein	)	HUMAN		253	UniRef50_P04156
Major prion protein		SAISC		260
Major prion protein		CEREL		256
Major prion protein	)	CEREN		256
Major prion protein		BUDTA		256
+435

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL133396 Genomic DNA No translation available. BK007887 Genomic DNA Translation: DAA34790.1
RefSeqⁱ	NP_001258490.1, NM_001271561.2 [F7VJQ1-1]
UniGeneⁱ	Hs.472010 Hs.610285 Hs.721670

3D structure databases

ProteinModelPortalⁱ	F7VJQ1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111606, 72 interactors

BioGridⁱ

111606, 72 interactors

PTM databases

SwissPalmⁱ	F7VJQ1

SwissPalmⁱ

F7VJQ1

Proteomic databases

PRIDEⁱ	F7VJQ1

PRIDEⁱ

F7VJQ1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	5621

GeneIDⁱ

5621

Organism-specific databases

CTDⁱ	5621
DisGeNETⁱ	5621
GeneCardsⁱ	PRNP
GeneReviewsⁱ	PRNP
HGNCⁱ	HGNC:9449 PRNP
MalaCardsⁱ	PRNP
neXtProtⁱ	NX_F7VJQ1
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Enzyme and pathway databases

SIGNORⁱ	F7VJQ1

SIGNORⁱ

F7VJQ1

Miscellaneous databases

ChiTaRSⁱ	PRNP human
GeneWikiⁱ	PRNP
GenomeRNAiⁱ	5621

Family and domain databases

ProtoNetⁱ	Search...

ProtoNetⁱ

Search...

Entry informationⁱ

Entry nameⁱ	APRIO_HUMAN
Accessionⁱ	F7VJQ1Primary (citable) accession number: F7VJQ1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2012
	Last sequence update:	September 21, 2011
	Last modified:	April 25, 2018
	This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F7VJQ1 (APRIO_HUMAN)

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Alternative prion protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Keywords - Domaini

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ