UniProtKB - F7VJQ1 (APRIO_HUMAN)
Protein
Alternative prion protein
Gene
PRNP
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
This protein is produced by a bicistronic gene which also produces the major prion protein/PRNP from an overlapping reading frame.1 Publication
The alternative prion protein/AltPrP and PRNP (AC P04156) have no apparent direct functional relation since a mutation that removes the start codon of the AltPrP has no apparent effect on the biology of PRNP. In mouse and hamster, the alternative initiation AUG codon is absent and is replaced by a GUG codon (PubMed:21478263).1 Publication
Enzyme and pathway databases
PathwayCommonsi | F7VJQ1 |
SIGNORi | F7VJQ1 |
Names & Taxonomyi
Protein namesi | Recommended name: Alternative prion proteinAlternative name(s): AltPrP |
Gene namesi | Name:PRNP Synonyms:ALTPRP, PRIP, PRP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9449, PRNP |
neXtProti | NX_F7VJQ1 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane 1 Publication; Single-pass membrane protein 1 Publication
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 32 – 52 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 5621 |
GeneReviewsi | PRNP |
MalaCardsi | PRNP |
Miscellaneous databases
Pharosi | F7VJQ1, Tbio |
Chemistry databases
DrugBanki | DB09130, Copper |
Genetic variation databases
BioMutai | PRNP |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000420424 | 1 – 73 | Alternative prion proteinAdd BLAST | 73 |
Proteomic databases
PRIDEi | F7VJQ1 |
PTM databases
SwissPalmi | F7VJQ1 |
Expressioni
Tissue specificityi
Detected in brain homogenate, primary neurons, and peripheral blood mononuclear cells (at protein level).1 Publication
Inductioni
Up-regulated by endoplasmic reticulum stress and proteasomal inhibition.1 Publication
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 25 – 64 | Trp-richAdd BLAST | 40 |
Keywords - Domaini
Transmembrane, Transmembrane helixs (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 3 (identifier: F7VJQ1-1) [UniParc]FASTAAdd to basket
Also known as: AltPrP
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEHWGQPIPG AGQPWRQPLP TSGRWWLGAA SWWWLGAASW WWLGAAPWWW
60 70
LGTASWWWLG SRRWHPQSVE QAE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2A2V1 | A2A2V1_HUMAN | Major prion protein | PRNP | 249 | Annotation score: | ||
X6RKS3 | X6RKS3_HUMAN | Major prion protein | PRNP | 217 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL133396 Genomic DNA No translation available. BK007887 Genomic DNA Translation: DAA34790.1 |
RefSeqi | NP_001258490.1, NM_001271561.2 [F7VJQ1-1] |
Genome annotation databases
GeneIDi | 5621 |
Keywords - Coding sequence diversityi
Alternative initiationSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL133396 Genomic DNA No translation available. BK007887 Genomic DNA Translation: DAA34790.1 |
RefSeqi | NP_001258490.1, NM_001271561.2 [F7VJQ1-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 111606, 93 interactors |
Chemistry databases
DrugBanki | DB09130, Copper |
PTM databases
SwissPalmi | F7VJQ1 |
Genetic variation databases
BioMutai | PRNP |
Proteomic databases
PRIDEi | F7VJQ1 |
Genome annotation databases
GeneIDi | 5621 |
Organism-specific databases
CTDi | 5621 |
DisGeNETi | 5621 |
GeneCardsi | PRNP |
GeneReviewsi | PRNP |
HGNCi | HGNC:9449, PRNP |
MalaCardsi | PRNP |
neXtProti | NX_F7VJQ1 |
GenAtlasi | Search... |
Enzyme and pathway databases
PathwayCommonsi | F7VJQ1 |
SIGNORi | F7VJQ1 |
Miscellaneous databases
BioGRID-ORCSi | 5621, 4 hits in 880 CRISPR screens |
ChiTaRSi | PRNP, human |
GeneWikii | PRNP |
GenomeRNAii | 5621 |
Pharosi | F7VJQ1, Tbio |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | APRIO_HUMAN | |
Accessioni | F7VJQ1Primary (citable) accession number: F7VJQ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2012 |
Last sequence update: | September 21, 2011 | |
Last modified: | February 10, 2021 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM