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Entry version 23 (11 Dec 2019)
Sequence version 1 (21 Sep 2011)
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Protein

Scavenger receptor cysteine-rich domain superfamily protein

Gene

SRCR1

Organism
Patiria pectinifera (Starfish) (Asterina pectinifera)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in aggregate formation and phagocytosis by larval mesenchyme cells and adult coelomocytes. Binds to bacteria and may act as an opsonin in the innate immune system.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Innate immunity, Phagocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Scavenger receptor cysteine-rich domain superfamily proteinImported
Short name:
ApSRCR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SRCR1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPatiria pectinifera (Starfish) (Asterina pectinifera)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7594 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaAsterozoaAsteroideaValvataceaValvatidaAsterinidaePatiria

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 1051ExtracellularSequence analysisAdd BLAST1027
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1052 – 1072HelicalSequence analysisAdd BLAST21
Topological domaini1073 – 1128CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000041560425 – 1128Scavenger receptor cysteine-rich domain superfamily proteinSequence analysisAdd BLAST1104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi65 ↔ 129Sequence analysis
Disulfide bondi78 ↔ 139Sequence analysis
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi109 ↔ 119Sequence analysis
Disulfide bondi168 ↔ 234Sequence analysis
Disulfide bondi181 ↔ 244Sequence analysis
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi212 ↔ 222Sequence analysis
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi273 ↔ 337Sequence analysis
Disulfide bondi286 ↔ 347Sequence analysis
Disulfide bondi316 ↔ 326Sequence analysis
Disulfide bondi376 ↔ 439Sequence analysis
Disulfide bondi389 ↔ 449Sequence analysis
Disulfide bondi419 ↔ 429Sequence analysis
Glycosylationi422N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi478 ↔ 542Sequence analysis
Disulfide bondi491 ↔ 552Sequence analysis
Disulfide bondi522 ↔ 532Sequence analysis
Disulfide bondi583 ↔ 644Sequence analysis
Disulfide bondi596 ↔ 653Sequence analysis
Glycosylationi601N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi612N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi624 ↔ 634Sequence analysis
Disulfide bondi682 ↔ 746Sequence analysis
Disulfide bondi695 ↔ 756Sequence analysis
Disulfide bondi726 ↔ 736Sequence analysis
Glycosylationi765N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi803 ↔ 865Sequence analysis
Glycosylationi808N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi833 ↔ 843Sequence analysis
Glycosylationi834N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi906 ↔ 967Sequence analysis
Glycosylationi936N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi937 ↔ 947Sequence analysis
Disulfide bondi971 ↔ 1013Sequence analysis
Glycosylationi985N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi999 ↔ 1026Sequence analysis
Glycosylationi1031N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
F7J220

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

From the mid-gastrula stage, expressed only in mesenchyme cells that are migrating toward the body wall. At the brachiolaria stage, expressed in presumptive coelomocytes of the coelomic pouch. Also expressed in adult coelomocytes (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During larval development, expression is first detected in the mid-gastrula stage and increases thereafter (at protein level).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By bacterial challenge in adult coelomocytes.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F7J220

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 140SRCR 1PROSITE-ProRule annotationAdd BLAST101
Domaini143 – 245SRCR 2PROSITE-ProRule annotationAdd BLAST103
Domaini248 – 348SRCR 3PROSITE-ProRule annotationAdd BLAST101
Domaini351 – 450SRCR 4PROSITE-ProRule annotationAdd BLAST100
Domaini453 – 553SRCR 5PROSITE-ProRule annotationAdd BLAST101
Domaini555 – 654SRCR 6PROSITE-ProRule annotationAdd BLAST100
Domaini657 – 757SRCR 7PROSITE-ProRule annotationAdd BLAST101
Domaini759 – 866SRCR 8PROSITE-ProRule annotationAdd BLAST108
Domaini868 – 968SRCR 9PROSITE-ProRule annotationAdd BLAST101
Domaini969 – 1028SushiPROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.250.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00530 SRCR, 9 hits
PF00084 Sushi, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00258 SPERACTRCPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 1 hit
SM00202 SR, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56487 SSF56487, 9 hits
SSF57535 SSF57535, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00420 SRCR_1, 5 hits
PS50287 SRCR_2, 9 hits
PS50923 SUSHI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

F7J220-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSLRRGNIC WVAVCAALLT LTRGIDVIAK PSRTPSNGDV QLVGGASPAE
60 70 80 90 100
GRVEVFYNGA WGTVCDDGWE MQDAQIVCKQ LGFASANSTR CCASFGQGTG
110 120 130 140 150
VIILDDLACT GDETRIGDCP HRGWEQHNCA HTEDAGVVCN GKVRLAGSPN
160 170 180 190 200
PLQGRLEIFH EGEWGTVCDS DWDLKDASVV CRQLGYPSAN SSSNVSFGPA
210 220 230 240 250
STAQILLDRV SCMGDEHGVE YCEHGDWKNV SADCTHSRDA GVICTRPIRL
260 270 280 290 300
VGGNGPMQGR VEILHNGEWG SVCDKGWSFQ NAVVVCNQLG ATQPRRPQGV
310 320 330 340 350
PVGGGVGPTH MSFVNCDGTE ATLEQCSNSG WGNAGECGHS NDAGVICTPA
360 370 380 390 400
VRLVGGNTHI EGRVEVFNNG QWGSICPESW DAKDAEVACR QLGNYPLAEG
410 420 430 440 450
DCCPQFPADV GVVLDNVVCT GNESRIQDCA HQDWGVVDCS GGQAAGAKCQ
460 470 480 490 500
ATVQLVGGSH PLEGNVIVLR NGRWGSICDD NWDINDARVV CRQLGNYEAV
510 520 530 540 550
AATCCAKYGQ VPQEIILDDV ACQGEEGRIE DCYHATWGSH NCGGSESAGV
560 570 580 590 600
VCREIRLALD DSSSNLPKGR VEIVYNGVWG RICGTDWDLN DANVLCRQLY
610 620 630 640 650
NSTAESVHSF KNGSGPILLS NFKCTGSESN IFDCTHNPWG DYTCDDADAA
660 670 680 690 700
VVCRGGLRLA GGRTPLEGRV EVFHDGQWGT VCDDGWDLLD AKVVCTQLGN
710 720 730 740 750
YEALSAKCCA NFGQGTGPIL IDGLACNGNE DLIEDCRHEG WGSHNCQHYE
760 770 780 790 800
DAGVVCTDLR LTHENGSVST NTLTGRVEVL SSSGEWGAIC GKYWDKKDAE
810 820 830 840 850
VVCQQLFNTS AMDTRKFYLS SPDQLINMGE VQCNGSESLL LQCPRASKPF
860 870 880 890 900
TAQTCPGGET AGVLCKDIRL VSGNQREFGA VELLVDSQWG SICADNWGPN
910 920 930 940 950
EGAVACKQLG YCAAKGTQKG LQPARTQGKM HFSSMNCTGS ESRLRDCVHT
960 970 980 990 1000
YGGYTCNGLV FEAVVQCKAG CDWPGPIRHG SFSPNRSSYD PLTTIDVKCD
1010 1020 1030 1040 1050
AGYELMGSKT LQCVTGCDWS RPTPECQRIS NCSIGGGGKP SVGAQAGPAG
1060 1070 1080 1090 1100
GVMLIIGIIL GAVVMMLIAC VALYLKGRNK NIGRGNPATT SAIWKPKKEF
1110 1120
DELKEPVLSF SAMTAGGAGP EDGMGEDI
Length:1,128
Mass (Da):119,966
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDCAA7C79A022C736
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB621549 mRNA Translation: BAK39578.1

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB621549 mRNA Translation: BAK39578.1

3D structure databases

SMRiF7J220
ModBaseiSearch...

Proteomic databases

PRIDEiF7J220

Family and domain databases

CDDicd00033 CCP, 1 hit
Gene3Di3.10.250.10, 9 hits
InterProiView protein in InterPro
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00530 SRCR, 9 hits
PF00084 Sushi, 1 hit
PRINTSiPR00258 SPERACTRCPTR
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00202 SR, 9 hits
SUPFAMiSSF56487 SSF56487, 9 hits
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00420 SRCR_1, 5 hits
PS50287 SRCR_2, 9 hits
PS50923 SUSHI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRCR1_PATPE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7J220
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: September 21, 2011
Last modified: December 11, 2019
This is version 23 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
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