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Entry version 42 (02 Jun 2021)
Sequence version 1 (21 Sep 2011)
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Protein
Submitted name:

Calcium activated chloride channel

Gene

clca1.2.L

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, MetalloproteaseARBA annotation, Protease
Biological processTransportARBA annotation
LigandChlorideARBA annotation, Metal-bindingARBA annotation, ZincARBA annotation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M87.005

Transport Classification Database

More...
TCDBi
1.A.13.1.7, the epithelial chloride channel (e-clc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calcium activated chloride channelImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:clca1.2.LImported
Synonyms:clca1Imported, clca1.2Imported, xCLCA2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-22065380, clca1.2.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei904 – 931HelicalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500335580523 – 942Sequence analysisAdd BLAST920

Keywords - PTMi

Autocatalytic cleavageARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini301 – 472VWFAInterPro annotationAdd BLAST172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni873 – 898DisorderedSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CLCR family.ARBA annotation

Keywords - Domaini

SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
IRISKCF

Database of Orthologous Groups

More...
OrthoDBi
685640at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004727, CLCA_chordata
IPR013642, CLCA_N
IPR013783, Ig-like_fold
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08434, CLCA, 1 hit
PF00092, VWA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00327, VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300, SSF53300, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00868, hCaCC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50234, VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F7IYU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTFSSLFALV LTFHVFFASS TSIKLQNGGY EDIVIAINPG LRENFKIIEN
60 70 80 90 100
IQNMIKDATP YLFSATRNRV YIRSVKILIP ITWPNKNYTK ARTETYDKAD
110 120 130 140 150
VIIASPHVKF GDDPYTLQYG GCGEPGKYIH MTPDFFLDDN LISIYGPRGR
160 170 180 190 200
VFVHEWAHLR WGVFDEYNYE KPFYVTGTKN IEATRCSADI IGTYMKLCQG
210 220 230 240 250
RICNCIRDPQ TGLYEDGCVF VPERNQAAKS SIMYSQALPS VTEFCEKNHN
260 270 280 290 300
TEAPTLQNRI CNSRSTWDVI MNSTDIKSTP PKADSNLPVP TFSLLQSSDR
310 320 330 340 350
VVTLVLDVSG SMTSGDRIGR LYQAAEVFVM QIVEEGSHVG IVTFSTTTAV
360 370 380 390 400
LSKLVQVIDD TQRNKLKRLL PKTATGGTDI CKGIREGIKL NKEHDGSSSN
410 420 430 440 450
TELVLLTDGE DNYDTSLCFP DIKNSGAIIH FIALGPKPAT KLEQIVEMTG
460 470 480 490 500
GLRFLATDKV DALGLIDAFS SLKAGDGATS QHAIQLESSG SILKPKNCLT
510 520 530 540 550
GTVFIDKTVG NGTFFLVTWV TLVPSITLID PNGKVYTSKD FTSDTTSKSS
560 570 580 590 600
RLKIPGTAER GAWQYNLCNN HTANQAIGIL VTSMAADENV PPITVNAHMN
610 620 630 640 650
RDNNNFPEPM IVYASVNQGL LPVVNANVTA IIEPVNGKSV PLELYDNGAG
660 670 680 690 700
VDIVKNDGIY SGYFFEFQGN GRYSLKVRVE NSKKKSRLAL PRSRALYIPG
710 720 730 740 750
YLENGQITMN PSRPVINDED FYLGEFSRTA SGGSFIVNNI PPGVQPDLYK
760 770 780 790 800
PEKVTDLEAK IEGNTIVLTW TATGDDLDKG TVSGYDLRMN TNPSDLRNNF
810 820 830 840 850
DNSTTVNTSS LMPQIAGSSE SFTFVPNNIA IENGTILYFA LTAFDKVAHK
860 870 880 890 900
SDLSNIAQAA LLIPPTPAPT TVQPLPASTT VQKTPAPTTV LPPSSDDSSG
910 920 930 940
TLDITFLTMI VCSSVIIICI IISITVCIVN CRKKKRNPEI RP
Length:942
Mass (Da):103,214
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD45B9D2CCEF9DD35
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB591377 mRNA Translation: BAK40918.1

NCBI Reference Sequences

More...
RefSeqi
NP_001267590.1, NM_001280661.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
101027304

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:101027304

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB591377 mRNA Translation: BAK40918.1
RefSeqiNP_001267590.1, NM_001280661.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiM87.005
TCDBi1.A.13.1.7, the epithelial chloride channel (e-clc) family

Genome annotation databases

GeneIDi101027304
KEGGixla:101027304

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
101027304
XenbaseiXB-GENE-22065380, clca1.2.L

Phylogenomic databases

OMAiIRISKCF
OrthoDBi685640at2759

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR004727, CLCA_chordata
IPR013642, CLCA_N
IPR013783, Ig-like_fold
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF08434, CLCA, 1 hit
PF00092, VWA, 1 hit
SMARTiView protein in SMART
SM00327, VWA, 1 hit
SUPFAMiSSF53300, SSF53300, 1 hit
TIGRFAMsiTIGR00868, hCaCC, 1 hit
PROSITEiView protein in PROSITE
PS50234, VWFA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7IYU5_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7IYU5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 2, 2021
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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