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Entry version 41 (17 Jun 2020)
Sequence version 2 (20 Jun 2018)
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Protein
Submitted name:

AF4/FMR2 family member 1

Gene

AFF1

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AF4/FMR2 family member 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9483 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008225 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9483.ENSCJAP00000011185

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni106 – 254DisorderedSequence analysisAdd BLAST149
Regioni270 – 333DisorderedSequence analysisAdd BLAST64
Regioni374 – 767DisorderedSequence analysisAdd BLAST394
Regioni780 – 967DisorderedSequence analysisAdd BLAST188
Regioni1102 – 1138DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi106 – 175PolarSequence analysisAdd BLAST70
Compositional biasi176 – 193PolyampholyteSequence analysisAdd BLAST18
Compositional biasi221 – 249PolarSequence analysisAdd BLAST29
Compositional biasi319 – 333PolyampholyteSequence analysisAdd BLAST15
Compositional biasi379 – 434PolarSequence analysisAdd BLAST56
Compositional biasi467 – 494PolarSequence analysisAdd BLAST28
Compositional biasi593 – 613PolarSequence analysisAdd BLAST21
Compositional biasi617 – 631PolyampholyteSequence analysisAdd BLAST15
Compositional biasi711 – 736PolarSequence analysisAdd BLAST26
Compositional biasi789 – 841PolyampholyteSequence analysisAdd BLAST53
Compositional biasi842 – 856PolarSequence analysisAdd BLAST15
Compositional biasi918 – 938PolyampholyteSequence analysisAdd BLAST21
Compositional biasi939 – 961PolarSequence analysisAdd BLAST23
Compositional biasi1120 – 1138PolarSequence analysisAdd BLAST19

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGJB Eukaryota
ENOG410XRXU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006484_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7HX68

TreeFam database of animal gene trees

More...
TreeFami
TF326216

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007797 TF_AF4/FMR2

The PANTHER Classification System

More...
PANTHERi
PTHR10528 PTHR10528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05110 AF-4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

F7HX68-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFTERVNSS GSNLYNDDRN LLRIREKERR NQEAHQEKET FPEKIPLFGE
60 70 80 90 100
PYKTAKGDEL SSRIQNMLGN YEEVKEFLST KSHTHCLDAS ETRLGKPKYP
110 120 130 140 150
LIPDKGSSIP SNSFHTSIHH QSIHTPSSGP LSVGSISHNP KMSQPRTEPM
160 170 180 190 200
STLHAKSYGP PDSQHLTQDC LGQDGYSSTH HKKGDRKADG DHCASVTDSA
210 220 230 240 250
PERQISPLIS SLPSPVPPLS PIHSNQQTLS RMQGSNKVHG SNNNSKGYCP
260 270 280 290 300
AKSPKDLTVK VHDKEIPQDS LVAPPQAPSQ SFPPPSLPSK SVAMQQKPTA
310 320 330 340 350
YVRPMDGQDQ APSESPELKP LPEDYRQQTF EKTDLKVPAK VKLTKLKMPS
360 370 380 390 400
QSVEQTYSNE VHCVEEILKE MTHSWPPPLT AIHTPSTAEP SKFPFPTKDS
410 420 430 440 450
QHISSATQNQ KQYDTSSKTH PNSQQGTSSM LEDDLQLSDS EDSDSEQTPE
460 470 480 490 500
KPPSSSAPPS APQSLPEPVA SAHSSSAESE STSDSDSSSD SESESSSSDS
510 520 530 540 550
EENEPLETPA PEPEPPATNK WQLDNWLTKV SQPAVPPEGP GSTEPPQRHP
560 570 580 590 600
ESKGSSEGAA SQERSESKDP APKSSSRAPR APPEAPHPGK RSCQKSPAQQ
610 620 630 640 650
EPPQRQTVGT KQPKKPVKAS ARADSRASLH VEREPGLLPY GSRDQTSKDK
660 670 680 690 700
PKVKTKGRPR AAASRESKPA VPPSSEKKKH KSSLPAPSKA PSGPEPTKDN
710 720 730 740 750
VEDRSPEHFA LVPLTQSQGP SHSGGGSRTS GCRQAVVVQE DSRKDRLQLP
760 770 780 790 800
LRDTKLLSPL RDTPLPQSLM VKITLDLLSR IPQPPGKGSR QRKAEDKQPP
810 820 830 840 850
TGKKHSSEKR SSDSSSKLAK KRKGEAERDC DNKKIRLEKE IKPQSSSSSS
860 870 880 890 900
SSSHKESSKT KSSRPSSESS KKEMLPPPPV SSSSQKPAKP GHKRSRREAD
910 920 930 940 950
TCSQDPPKSA SSTKSSHKDS SIPKHRRVEG KGSRSSSEHK GSSGDTANPF
960 970 980 990 1000
SVPSLPNGNS KPGKPQVKFD KQQADLHMRE AKKLKQKAES MTDKVGKAFK
1010 1020 1030 1040 1050
YLEAVLSLIE CGIAMESESQ ASKSAYSVYS ETVDLIKFIM SLKSFSDVTA
1060 1070 1080 1090 1100
PTQEKIFAIL CMRCQSILNM AMFRCKKDIA IKYSRTLNKH FESSSKVAQA
1110 1120 1130 1140 1150
PSPCIARSTG TPSPLSPMPS PASSIGSQSS AGSVGSSGGM AATVNTPVTI
1160 1170 1180 1190 1200
QNMTSSYVTI TSHVLTAFDL WEQAEALTRK NKEFFAQLST NVCTLALNSS
1210 1220
LVDLVRYTRQ GFQQLQELTK TP
Length:1,222
Mass (Da):132,872
Last modified:June 20, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD33A25212D7FB31
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5K1UYS2A0A5K1UYS2_CALJA
AF4/FMR2 family member 1
AFF1
1,214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8P0Z3A0A2R8P0Z3_CALJA
AF4/FMR2 family member 1
AFF1
1,185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F4WCG6A0A5F4WCG6_CALJA
AF4/FMR2 family member 1
AFF1
1,175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCJAT00000011804; ENSCJAP00000011185; ENSCJAG00000006047

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000011185

Genome annotation databases

EnsembliENSCJAT00000011804; ENSCJAP00000011185; ENSCJAG00000006047

Phylogenomic databases

eggNOGiENOG410IGJB Eukaryota
ENOG410XRXU LUCA
GeneTreeiENSGT00950000182974
HOGENOMiCLU_006484_0_0_1
InParanoidiF7HX68
TreeFamiTF326216

Family and domain databases

InterProiView protein in InterPro
IPR007797 TF_AF4/FMR2
PANTHERiPTHR10528 PTHR10528, 1 hit
PfamiView protein in Pfam
PF05110 AF-4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7HX68_CALJA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7HX68
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: June 20, 2018
Last modified: June 17, 2020
This is version 41 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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