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UniProtKB - F7HX68 (F7HX68_CALJA)

Entry version 46 (07 Apr 2021)
Sequence version 2 (20 Jun 2018)
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Protein
Submitted name:

AF4/FMR2 family member 1

Gene

AFF1

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AF4/FMR2 family member 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9483 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Callitrichinae › Callithrix › Callithrix
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008225 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9483.ENSCJAP00000011185

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini959 – 1221AF-4_CInterPro annotationAdd BLAST263

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni106 – 254DisorderedSequence analysisAdd BLAST149
Regioni270 – 333DisorderedSequence analysisAdd BLAST64
Regioni374 – 767DisorderedSequence analysisAdd BLAST394
Regioni780 – 967DisorderedSequence analysisAdd BLAST188
Regioni1102 – 1138DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi106 – 175PolarSequence analysisAdd BLAST70
Compositional biasi176 – 193PolyampholyteSequence analysisAdd BLAST18
Compositional biasi221 – 249PolarSequence analysisAdd BLAST29
Compositional biasi319 – 333PolyampholyteSequence analysisAdd BLAST15
Compositional biasi379 – 434PolarSequence analysisAdd BLAST56
Compositional biasi467 – 494PolarSequence analysisAdd BLAST28
Compositional biasi593 – 613PolarSequence analysisAdd BLAST21
Compositional biasi617 – 631PolyampholyteSequence analysisAdd BLAST15
Compositional biasi711 – 736PolarSequence analysisAdd BLAST26
Compositional biasi789 – 841PolyampholyteSequence analysisAdd BLAST53
Compositional biasi842 – 856PolarSequence analysisAdd BLAST15
Compositional biasi918 – 938PolyampholyteSequence analysisAdd BLAST21
Compositional biasi939 – 961PolarSequence analysisAdd BLAST23
Compositional biasi1120 – 1138PolarSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AF4 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QVDA, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006484_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F7HX68

Identification of Orthologs from Complete Genome Data

More...OMAi		HEREEKP

TreeFam database of animal gene trees

More...TreeFami		TF326216

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int

The PANTHER Classification System

More...PANTHERi		PTHR10528, PTHR10528, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

F7HX68-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFTERVNSS GSNLYNDDRN LLRIREKERR NQEAHQEKET FPEKIPLFGE 
        60         70         80         90        100
PYKTAKGDEL SSRIQNMLGN YEEVKEFLST KSHTHCLDAS ETRLGKPKYP 
       110        120        130        140        150
LIPDKGSSIP SNSFHTSIHH QSIHTPSSGP LSVGSISHNP KMSQPRTEPM 
       160        170        180        190        200
STLHAKSYGP PDSQHLTQDC LGQDGYSSTH HKKGDRKADG DHCASVTDSA 
       210        220        230        240        250
PERQISPLIS SLPSPVPPLS PIHSNQQTLS RMQGSNKVHG SNNNSKGYCP 
       260        270        280        290        300
AKSPKDLTVK VHDKEIPQDS LVAPPQAPSQ SFPPPSLPSK SVAMQQKPTA 
       310        320        330        340        350
YVRPMDGQDQ APSESPELKP LPEDYRQQTF EKTDLKVPAK VKLTKLKMPS 
       360        370        380        390        400
QSVEQTYSNE VHCVEEILKE MTHSWPPPLT AIHTPSTAEP SKFPFPTKDS 
       410        420        430        440        450
QHISSATQNQ KQYDTSSKTH PNSQQGTSSM LEDDLQLSDS EDSDSEQTPE 
       460        470        480        490        500
KPPSSSAPPS APQSLPEPVA SAHSSSAESE STSDSDSSSD SESESSSSDS 
       510        520        530        540        550
EENEPLETPA PEPEPPATNK WQLDNWLTKV SQPAVPPEGP GSTEPPQRHP 
       560        570        580        590        600
ESKGSSEGAA SQERSESKDP APKSSSRAPR APPEAPHPGK RSCQKSPAQQ 
       610        620        630        640        650
EPPQRQTVGT KQPKKPVKAS ARADSRASLH VEREPGLLPY GSRDQTSKDK 
       660        670        680        690        700
PKVKTKGRPR AAASRESKPA VPPSSEKKKH KSSLPAPSKA PSGPEPTKDN 
       710        720        730        740        750
VEDRSPEHFA LVPLTQSQGP SHSGGGSRTS GCRQAVVVQE DSRKDRLQLP 
       760        770        780        790        800
LRDTKLLSPL RDTPLPQSLM VKITLDLLSR IPQPPGKGSR QRKAEDKQPP 
       810        820        830        840        850
TGKKHSSEKR SSDSSSKLAK KRKGEAERDC DNKKIRLEKE IKPQSSSSSS 
       860        870        880        890        900
SSSHKESSKT KSSRPSSESS KKEMLPPPPV SSSSQKPAKP GHKRSRREAD 
       910        920        930        940        950
TCSQDPPKSA SSTKSSHKDS SIPKHRRVEG KGSRSSSEHK GSSGDTANPF 
       960        970        980        990       1000
SVPSLPNGNS KPGKPQVKFD KQQADLHMRE AKKLKQKAES MTDKVGKAFK 
      1010       1020       1030       1040       1050
YLEAVLSLIE CGIAMESESQ ASKSAYSVYS ETVDLIKFIM SLKSFSDVTA 
      1060       1070       1080       1090       1100
PTQEKIFAIL CMRCQSILNM AMFRCKKDIA IKYSRTLNKH FESSSKVAQA 
      1110       1120       1130       1140       1150
PSPCIARSTG TPSPLSPMPS PASSIGSQSS AGSVGSSGGM AATVNTPVTI 
      1160       1170       1180       1190       1200
QNMTSSYVTI TSHVLTAFDL WEQAEALTRK NKEFFAQLST NVCTLALNSS 
      1210       1220 
LVDLVRYTRQ GFQQLQELTK TP
Length:1,222
Mass (Da):132,872
Last modified:June 20, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD33A25212D7FB31
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8P0Z3A0A2R8P0Z3_CALJA
AF4/FMR2 family member 1
AFF1
1,185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F4WCG6A0A5F4WCG6_CALJA
AF4/FMR2 family member 1
AFF1
1,175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5K1UYS2A0A5K1UYS2_CALJA
AF4/FMR2 family member 1
AFF1
1,214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSCJAT00000011804; ENSCJAP00000011185; ENSCJAG00000006047

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000011185

Genome annotation databases

EnsembliENSCJAT00000011804; ENSCJAP00000011185; ENSCJAG00000006047

Phylogenomic databases

eggNOGiENOG502QVDA, Eukaryota
GeneTreeiENSGT00950000182974
HOGENOMiCLU_006484_0_0_1
InParanoidiF7HX68
OMAiHEREEKP
TreeFamiTF326216

Family and domain databases

InterProiView protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int
PANTHERiPTHR10528, PTHR10528, 1 hit
PfamiView protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7HX68_CALJA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7HX68
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: June 20, 2018
Last modified: April 7, 2021
This is version 46 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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