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Protein

Mothers against decapentaplegic homolog

Gene

SMAD2

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mothers against decapentaplegic homologUniRule annotation
Short name:
MAD homologUniRule annotation
Short name:
Mothers against DPP homologUniRule annotation
Alternative name(s):
SMAD family memberUniRule annotation
Gene namesi
Name:SMAD2Imported
OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
Proteomesi
  • UP000008225 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000008523

Structurei

3D structure databases

SMRiF7HWK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 176MH1InterPro annotationAdd BLAST167
Domaini274 – 467MH2InterPro annotationAdd BLAST194

Sequence similaritiesi

Belongs to the dwarfin/SMAD family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3701 Eukaryota
ENOG410XQKU LUCA
GeneTreeiENSGT00760000119091
KOiK04500
OMAiDEICINP
OrthoDBiEOG091G082C
TreeFamiTF314923

Family and domain databases

Gene3Di2.60.200.10, 1 hit
InterProiView protein in InterPro
IPR013790 Dwarfin
IPR003619 MAD_homology1_Dwarfin-type
IPR013019 MAD_homology_MH1
IPR017855 SMAD-like_dom_sf
IPR001132 SMAD_dom_Dwarfin-type
IPR008984 SMAD_FHA_dom_sf
IPR036578 SMAD_MH1_sf
PANTHERiPTHR13703 PTHR13703, 1 hit
PfamiView protein in Pfam
PF03165 MH1, 1 hit
PF03166 MH2, 1 hit
SMARTiView protein in SMART
SM00523 DWA, 1 hit
SM00524 DWB, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF56366 SSF56366, 2 hits
PROSITEiView protein in PROSITE
PS51075 MH1, 1 hit
PS51076 MH2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

F7HWK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK
60 70 80 90 100
KLKKTGRLDE LEKAITTQNC NTKCVTIPST CSEIWGLSTP NTIDQWDTTG
110 120 130 140 150
LYSFSEQTRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELKAIENCE
160 170 180 190 200
YAFNLKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEILTEL PPLDDYTHSI
210 220 230 240 250
PENTNFPAGI EPQSNYIPET PPPGYISEDG ETSDQQLNQS MDTGSPAELS
260 270 280 290 300
PTTLSPVNHS LDLQPVTYSE PAFWCSIAYY ELNQRVGETF HASQPSLTVD
310 320 330 340 350
GFTDPSNSER FCLGLLSNVN RNATVEMTRR HIGRGVRLYY IGGEVFAECL
360 370 380 390 400
SDSAIFVQSP NCNQRYGWHP ATVCKIPPGC NLKIFNNQEF AALLAQSVNQ
410 420 430 440 450
GFEAVYQLTR MCTIRMSFVK GWGAEYRRQT VTSTPCWIEL HLNGPLQWLD
460
KVLTQMGSPS VRCSSMS
Length:467
Mass (Da):52,306
Last modified:July 27, 2011 - v1
Checksum:i95406DB5FC0AA4C9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3EJ65U3EJ65_CALJA
Mothers against decapentaplegic hom...
SMAD2
437Annotation score:
A0A2R8M5L4A0A2R8M5L4_CALJA
Mothers against decapentaplegic hom...
SMAD2
429Annotation score:
A0A2R8PD95A0A2R8PD95_CALJA
SMAD family member 2
SMAD2
188Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFV01106416 Genomic DNA No translation available.
ACFV01106417 Genomic DNA No translation available.
ACFV01106418 Genomic DNA No translation available.
ACFV01106419 Genomic DNA No translation available.
ACFV01106420 Genomic DNA No translation available.
ACFV01106421 Genomic DNA No translation available.
GAMT01003393 mRNA Translation: JAB08468.1
GAMS01007621 mRNA Translation: JAB15515.1
GAMR01004334 mRNA Translation: JAB29598.1
GAMQ01002004 mRNA Translation: JAB39847.1
GAMP01001831 mRNA Translation: JAB50924.1
RefSeqiXP_008978001.1, XM_008979753.2
XP_017818950.1, XM_017963461.1

Genome annotation databases

EnsembliENSCJAT00000009015; ENSCJAP00000008523; ENSCJAG00000004630
GeneIDi100396826
KEGGicjc:100396826

Similar proteinsi

Entry informationi

Entry nameiF7HWK8_CALJA
AccessioniPrimary (citable) accession number: F7HWK8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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