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Protein
Submitted name:

Centromere protein E

Gene

CENPE

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi86 – 93ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor proteinPROSITE-ProRule annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Centromere protein EImported
Gene namesi
Name:CENPEImported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMMUG00000019089
ExpressionAtlasiF7HML7 baseline

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 329Kinesin motorInterPro annotationAdd BLAST324

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili338 – 365Sequence analysisAdd BLAST28
Coiled coili493 – 534Sequence analysisAdd BLAST42
Coiled coili556 – 604Sequence analysisAdd BLAST49
Coiled coili634 – 696Sequence analysisAdd BLAST63
Coiled coili715 – 776Sequence analysisAdd BLAST62
Coiled coili833 – 867Sequence analysisAdd BLAST35
Coiled coili875 – 951Sequence analysisAdd BLAST77
Coiled coili959 – 993Sequence analysisAdd BLAST35
Coiled coili1052 – 1083Sequence analysisAdd BLAST32
Coiled coili1112 – 1180Sequence analysisAdd BLAST69
Coiled coili1198 – 1225Sequence analysisAdd BLAST28
Coiled coili1244 – 1288Sequence analysisAdd BLAST45
Coiled coili1323 – 1385Sequence analysisAdd BLAST63
Coiled coili1430 – 1478Sequence analysisAdd BLAST49
Coiled coili1486 – 1538Sequence analysisAdd BLAST53
Coiled coili1564 – 1626Sequence analysisAdd BLAST63
Coiled coili1646 – 1666Sequence analysisAdd BLAST21
Coiled coili1684 – 1715Sequence analysisAdd BLAST32
Coiled coili1730 – 1764Sequence analysisAdd BLAST35
Coiled coili1783 – 1869Sequence analysisAdd BLAST87
Coiled coili1871 – 1918Sequence analysisAdd BLAST48
Coiled coili1933 – 2016Sequence analysisAdd BLAST84
Coiled coili2034 – 2054Sequence analysisAdd BLAST21
Coiled coili2325 – 2352Sequence analysisAdd BLAST28
Coiled coili2376 – 2424Sequence analysisAdd BLAST49
Coiled coili2542 – 2590Sequence analysisAdd BLAST49

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0242 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00910000143992
KOiK11498

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 2 hits
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

F7HML7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEGAVAVC VRVRPLNSRE ESLGETAQVY WKTDNNAIYQ VDGSKSFNFD
60 70 80 90 100
RVFHGNETTK NVYEEIAAPI IDSAIQGYNG TIFAYGQTAS GKTYTMMGSE
110 120 130 140 150
DHLGVTPRAI HDIFQKIKKF PDREFLLRVS YMEIYNETIT DLLCGTQKMK
160 170 180 190 200
PLIIREDVNR NVYVADLTEE VVYTSEMALK WITKGEKNRH YGETKMNQRS
210 220 230 240 250
SRSHTIFRMI LESREKGEPS NCEGSVKVSH LNLVDLAGSE RAAQTGAEGV
260 270 280 290 300
RLKEGCNINR SLFILGQVIK KLSDGQVGGF INYRDSKLTR ILQNSLGGNA
310 320 330 340 350
KTRIICTITP VSFDETLTTL QFASTAKYMK NTPYVNEVST DEALLKRYRK
360 370 380 390 400
EIMDLKKQLE EVSLETRAQA MEKDQLAQLL EEKDLLQKVQ NEKIENLTRM
410 420 430 440 450
LVTSSSLTSQ QELKAKRKRR VTWCLGKINK MKNSNYVDQF NMPTNITTKT
460 470 480 490 500
HKLSINVLGE IDESVCSESD VFSNTLDTLN EIEWNPATKL LNQENIESEL
510 520 530 540 550
NSLRADYDNL VLDYEQLRTE KEEMELKLKE KNDLDEFEAL ERKTKKDQEM
560 570 580 590 600
QLIHEISNLK NLVKHAEVYN QDLENELSSK VELLREKEDQ IKKLQEYIDS
610 620 630 640 650
QKLENIKMDL SYSLESIEDQ KQMKQTLFDA ETVALDAKRE SAFLRSENLE
660 670 680 690 700
LKEKMQELAS TYKQMENDIQ LYQSQLEAKK KMQVDLEKEL QSAFNEITKL
710 720 730 740 750
TSLIDGKVPK DLLYNLELEG KITDLQKELN KEVEENEALR KEVNLLSELK
760 770 780 790 800
SLPSEVERLR KEIHDKSEEL HIITSEKHKL FSEVVHKESR VQGLLEEIGK
810 820 830 840 850
TKDDLATTQS NYKSTDQEFQ NFKSLHIDFE QKYKMVLEEN ARMNQEIVNL
860 870 880 890 900
SKEAQKFDSS LDALKTELSY KTQELQKKTC EVQERLNEMK ELKEQLENRD
910 920 930 940 950
STLQTVEREK TLITEKLQQT LEEVKTLTQE KDDLKQLQKS LQIERDQLKS
960 970 980 990 1000
DIHDTVNMNI DTQEQLRNAL ESLKQHQETI NTLKLKISEE VSRNLHMEEN
1010 1020 1030 1040 1050
TGETKDEFQQ KMVDIDKKQD LEAKNTQTLT ADVKDDEIIE QQRKIFSLIQ
1060 1070 1080 1090 1100
EKNELQQVLE SVIAEKEQLK TDLKENIEMT IENQEELRIL GDELKKQQEI
1110 1120 1130 1140 1150
VAQEKNHTIK KEEELSRTCD RLAEVEEKLK EKSQQLQEKQ QQLLNVQEEM
1160 1170 1180 1190 1200
SEMQKKINEM ENLKNELKNK ELTLEHRETE RLGLAQKLNE NYEEMKSITK
1210 1220 1230 1240 1250
ERKVLKELQE SFETERDQLR GYIREIEATG LQTKEELKIA HIHLKEHQET
1260 1270 1280 1290 1300
IDELRRSVSE KTAQIINIQD LEKSYTKLQE EIPVLNEERE LLPNVKEVSE
1310 1320 1330 1340 1350
TQETVNELEL LKEQSTIKDS TTLASIEMER LKLNEKFQES QEEIKSLTKE
1360 1370 1380 1390 1400
RDNLKMIKEA LEVKHDQLKE HIRETLAKIQ ESQSKQEQSL NMKEKDNETT
1410 1420 1430 1440 1450
KILSEMEQFK PKDSALLRIE IEMLRLSKRL QESHDEMKSV AKEKDDLQRL
1460 1470 1480 1490 1500
QEVLQSESDQ LKENIKEIAA KHLETEEELK VVHCCLKEQK ETIDELRVNI
1510 1520 1530 1540 1550
SEKETEISTI QKELEAINDK LQNKIQEIYK KEEQLNIKRI SETQEKVNEL
1560 1570 1580 1590 1600
KQFKEYLKAK DSTLQSIESK MLELTSRLQE SQEEIQIMIK EKEEMKRVQE
1610 1620 1630 1640 1650
ALQIERDQLQ ENTKEIIAKM QESQEKEYQF LKMTAVNETQ EKMCEIEHLK
1660 1670 1680 1690 1700
EQFETQKLNL ENTETENIRL TQILHENLEE MRSVTKERDD LRNVEETLKV
1710 1720 1730 1740 1750
ERDQLKENLR ETITRDLEKQ EELKIVHMYL KEHQETIDEL RGIVSEKTNE
1760 1770 1780 1790 1800
ISNMQKDLEN SNAALKAQDL KKQEELRIAH MHLKEHQETI DKLRGIVSEK
1810 1820 1830 1840 1850
TDKISNMQKD LENSNAKLQE KIQELKANEH QLFKLKKDVN ETQKKVSEME
1860 1870 1880 1890 1900
QLKKQIKDQS LTLSKIETEN LNLAQKLHEN LEEMKSVMKE RDNLRRVEET
1910 1920 1930 1940 1950
LKLERDQLME SLQETKARDL EIQQELKTAH MLSKEHKETI DKLREKILEK
1960 1970 1980 1990 2000
TTQISNIQKD LDKSKDELQK KIQELQKKEL HLLRMKEDVN MSHKKINEME
2010 2020 2030 2040 2050
QLKKQFEAQN LSVQNVRMDN FQLTKKLHES LEEIRIVAKE RDELRRIKES
2060 2070 2080 2090 2100
LKMEGDQFVA TLREMIARDQ QNHQVKPEKR LLSDGQQHLT ESLREKCSRI
2110 2120 2130 2140 2150
KELLKRYSEM DDHYECLNRL SLDLEKEIEI QKELSMRVKA NLSLPYLQTK
2160 2170 2180 2190 2200
HIEKLFTANQ RCSMEFHRIM KKLKYVLSYV TKIKEEQHES INKFEMDFID
2210 2220 2230 2240 2250
EVEKQKELLI KIQHLQQDCD VPSRELRDLK LNQNMDLHIE EILKDFSESE
2260 2270 2280 2290 2300
FPTIKTEFQQ ILSNRKEMTQ FLEEWLNTRF DIEKLKNGIQ KENDRICQMN
2310 2320 2330 2340 2350
NFFNNRIIAI MNESTEFEER SATISKEWEQ DLKSLKEKNE KLFKNYQTLK
2360 2370 2380 2390 2400
TSLASGAQVN PTTQDNKNPH VTSRATQLTT EKIRELENSL HEAKESAMHK
2410 2420 2430 2440 2450
ESEIIKMQKE LEVTNDMIAK LQAKVNESNK CLETTKETIQ VLQDKVALGA
2460 2470 2480 2490 2500
KPYKEEIEDL KTKLVKIDLE KMKNAKEFEK EISATKATVE YQKEVIRLLR
2510 2520 2530 2540 2550
ENLRRSQQAQ DTSMISEHTD SQPSNKPLTC GGGSGIVQNT KALILKSEHI
2560 2570 2580 2590 2600
RLEKEISKLK QQNEQLIKQK NDLLSNNQHL SNEVKTWKER TLKREAYKQV
2610 2620 2630 2640 2650
TCENSPKSPK VTGTASKKKQ ITPSQCKERN LHDPMPKESP KSWFFDSRSK
2660 2670 2680 2690 2700
SLPSPHPVRY FDNSNLGLCP EVQNAGAESV DSQPGPWHAS SGKDVPECKT

Q
Length:2,701
Mass (Da):316,791
Last modified:November 30, 2016 - v2
Checksum:i2DEE254798D82BC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03034147 Genomic DNA No translation available.
JSUE03034148 Genomic DNA No translation available.
RefSeqiXP_001110512.2, XM_001110512.2
UniGeneiMmu.28351

Genome annotation databases

EnsembliENSMMUT00000041920; ENSMMUP00000034930; ENSMMUG00000019089
GeneIDi711186
KEGGimcc:711186

Similar proteinsi

Entry informationi

Entry nameiF7HML7_MACMU
AccessioniPrimary (citable) accession number: F7HML7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: November 30, 2016
Last modified: July 18, 2018
This is version 57 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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