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Entry version 72 (02 Dec 2020)
Sequence version 3 (11 Dec 2019)
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Protein
Submitted name:

Transmembrane serine protease 6

Gene

TMPRSS6

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.308

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transmembrane serine protease 6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMPRSS6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca mulatta (Rhesus macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9544 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006718 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:79038, TMPRSS6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei44 – 65HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi433 ↔ 445PROSITE-ProRule annotation
Disulfide bondi449 ↔ 464PROSITE-ProRule annotation
Disulfide bondi466 ↔ 478PROSITE-ProRule annotation
Disulfide bondi485 ↔ 500PROSITE-ProRule annotation
Disulfide bondi506 ↔ 518PROSITE-ProRule annotation
Disulfide bondi526 ↔ 541PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMMUG00000000151, Expressed in ileum and 9 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F7HM00, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9544.ENSMMUP00000000208

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini73 – 198SEAInterPro annotationAdd BLAST126
Domaini310 – 427CUBInterPro annotationAdd BLAST118
Domaini552 – 870Peptidase S1InterPro annotationAdd BLAST319

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30
Regioni839 – 860DisorderedSequence analysisAdd BLAST22

Keywords - Domaini

Signal-anchorARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3627, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160104

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006842_19_3_1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041, CUB, 1 hit
cd00112, LDLa, 3 hits
cd00190, Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 1 hit
2.60.120.290, 1 hit
3.30.70.960, 1 hit
4.10.400.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR036055, LDL_receptor-like_sf
IPR002172, LDrepeatLR_classA_rpt
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR000082, SEA_dom
IPR036364, SEA_dom_sf
IPR035914, Sperma_CUB_dom_sf
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00057, Ldl_recept_a, 2 hits
PF01390, SEA, 1 hit
PF00089, Trypsin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00192, LDLa, 3 hits
SM00020, Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 2 hits
SSF50494, SSF50494, 1 hit
SSF57424, SSF57424, 3 hits
SSF82671, SSF82671, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180, CUB, 1 hit
PS50068, LDLRA_2, 3 hits
PS50024, SEA, 1 hit
PS50240, TRYPSIN_DOM, 1 hit
PS00134, TRYPSIN_HIS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F7HM00-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVAKAPQVA GGQGDGGDGE EAEPEGMFEA REDSKRKARG YLRLAPLWLT
60 70 80 90 100
LVVLTSVGVL LWYFLGYKAE VTVSQVYSGS LRVLNRHFSQ DLTRRESSAF
110 120 130 140 150
RSETAKAQKM LKELIASTRL GTYYNSSSVY SFGEGPLTCF FWFILQIPEH
160 170 180 190 200
RRPMLSPEVV QALLVEELLS TVNSSAAVPY RAEYEVDPEG LVILGCYRYS
210 220 230 240 250
YVGQGQVLRL KGPDHLASSC LWHLQGPEDL MLKLRLEWTL AECRDRLAMY
260 270 280 290 300
DVAGPLEKRL ITSVYGCSRQ EPVVEVLASG AIMAVVWKKG LHSYYDPFML
310 320 330 340 350
SVQSVVFQAC EVNLTLDDRL DSQGVLSTPY FPSYYSPRTH CSWHLTVPSL
360 370 380 390 400
DYGLALWFDA YALRRQKYDL PCTQGQWTIQ NRRLCGLRIL QPYAERIPVV
410 420 430 440 450
ATAGITINFT SQISLTGPGV RVHYGLYNQS DPCPGEFLCS VNGLCVPACD
460 470 480 490 500
GVKDCPNGLD ERNCVCRATF QCQEDSTCIS LLKVCDGQPD CLNGSDEERC
510 520 530 540 550
QEGVPCGTFT FQCEDQSCVK KPNPQCDGRP DCRDGSDEQH CDCGLQGPSS
560 570 580 590 600
RIVGGAVSSE GEWPWQASLQ VRGRHICGGA LIADRWVITA AHCFQEDSMA
610 620 630 640 650
SPALWTVFLG KVWQNSRWPG EVSFKVSRLL LHPYHEEDSH DYDVALLQLD
660 670 680 690 700
HPVVRSAAVR PVCLPARSHF FEPGLHCWIT GWGALREGGP TSNALQKVDV
710 720 730 740 750
QLIPQDLCSE AYRYQVTPRM LCAGYRKGKK DACQVSTPSV GGRKKGCCSH
760 770 780 790 800
HQGLALCSHQ PAEASHPPRK VAMAALTLQK RRLGVGRVEE LAQGCRAMDQ
810 820 830 840 850
KRCCDGQVLG SNPVLLLAHH KALGPGSHSE VDARKKKGVS ATEGRWRQSG
860 870 880 890 900
GVGTQPQFQE GPGWLEDKEG WLGLSPFSRR GKSRALRLNV SLWHPVNSQQ
910 920 930 940 950
SGLNPHGPSP GKGVPLPCFS PFSFPPFRVT RVVRWYARHS VAAGSWQGWS
960 970
AGAWAVAGLT TSASTPASQV
Length:970
Mass (Da):106,959
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F0A0FB1254D1E21
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7HLZ8F7HLZ8_MACMU
Transmembrane serine protease 6
TMPRSS6
756Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMMUT00000000220; ENSMMUP00000000207; ENSMMUG00000000151

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000000208

Protein family/group databases

MEROPSiS01.308

Genome annotation databases

EnsembliENSMMUT00000000220; ENSMMUP00000000207; ENSMMUG00000000151

Organism-specific databases

VGNCiVGNC:79038, TMPRSS6

Phylogenomic databases

eggNOGiKOG3627, Eukaryota
GeneTreeiENSGT00940000160104
HOGENOMiCLU_006842_19_3_1

Gene expression databases

BgeeiENSMMUG00000000151, Expressed in ileum and 9 other tissues
ExpressionAtlasiF7HM00, baseline

Family and domain databases

CDDicd00041, CUB, 1 hit
cd00112, LDLa, 3 hits
cd00190, Tryp_SPc, 1 hit
Gene3Di2.40.10.10, 1 hit
2.60.120.290, 1 hit
3.30.70.960, 1 hit
4.10.400.10, 3 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR036055, LDL_receptor-like_sf
IPR002172, LDrepeatLR_classA_rpt
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR000082, SEA_dom
IPR036364, SEA_dom_sf
IPR035914, Sperma_CUB_dom_sf
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
PfamiView protein in Pfam
PF00057, Ldl_recept_a, 2 hits
PF01390, SEA, 1 hit
PF00089, Trypsin, 1 hit
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00192, LDLa, 3 hits
SM00020, Tryp_SPc, 1 hit
SUPFAMiSSF49854, SSF49854, 2 hits
SSF50494, SSF50494, 1 hit
SSF57424, SSF57424, 3 hits
SSF82671, SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS01180, CUB, 1 hit
PS50068, LDLRA_2, 3 hits
PS50024, SEA, 1 hit
PS50240, TRYPSIN_DOM, 1 hit
PS00134, TRYPSIN_HIS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7HM00_MACMU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7HM00
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: December 2, 2020
This is version 72 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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