UniProtKB - F7HG05 (F7HG05_MACMU)
Protein
Submitted name:
Afadin, adherens junction formation factor
Gene
AFDN
Organism
Macaca mulatta (Rhesus macaque)
Status
Functioni
GO - Molecular functioni
- actin filament binding Source: Ensembl
- cell adhesion molecule binding Source: GO_Central
- Ras GTPase binding Source: Ensembl
GO - Biological processi
- bicellular tight junction assembly Source: Ensembl
- cell adhesion Source: UniProtKB-KW
- establishment of endothelial intestinal barrier Source: Ensembl
- negative regulation of cell migration Source: Ensembl
- pore complex assembly Source: Ensembl
- positive regulation of cell-cell adhesion mediated by cadherin Source: Ensembl
- positive regulation of gene expression Source: Ensembl
- positive regulation of GTPase activity Source: Ensembl
- regulation of protein localization Source: GO_Central
- signal transduction Source: InterPro
Keywordsi
Biological process | Cell adhesionARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Afadin, adherens junction formation factorImported |
Gene namesi | Name:AFDNImported |
Organismi | Macaca mulatta (Rhesus macaque)Imported |
Taxonomic identifieri | 9544 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:69818, AFDN |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- nuclear speck Source: Ensembl
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- adherens junction Source: GO_Central
- cell-cell contact zone Source: Ensembl
- pore complex Source: Ensembl
- tight junction Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSMMUG00000021044, Expressed in lung and 23 other tissues |
ExpressionAtlasi | F7HG05, baseline |
Interactioni
GO - Molecular functioni
- actin filament binding Source: Ensembl
- cell adhesion molecule binding Source: GO_Central
- Ras GTPase binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 134 | Ras-associatingInterPro annotationAdd BLAST | 96 | |
Domaini | 247 – 349 | Ras-associatingInterPro annotationAdd BLAST | 103 | |
Domaini | 654 – 901 | DiluteInterPro annotationAdd BLAST | 248 | |
Domaini | 1000 – 1086 | PDZInterPro annotationAdd BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 129 – 195 | DisorderedSequence analysisAdd BLAST | 67 | |
Regioni | 350 – 379 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 520 – 581 | DisorderedSequence analysisAdd BLAST | 62 | |
Regioni | 1100 – 1183 | DisorderedSequence analysisAdd BLAST | 84 | |
Regioni | 1195 – 1216 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1228 – 1521 | DisorderedSequence analysisAdd BLAST | 294 | |
Regioni | 1562 – 1712 | DisorderedSequence analysisAdd BLAST | 151 | |
Regioni | 1724 – 1892 | DisorderedSequence analysisAdd BLAST | 169 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 144 – 195 | PolyampholyteSequence analysisAdd BLAST | 52 | |
Compositional biasi | 350 – 370 | PolyampholyteSequence analysisAdd BLAST | 21 | |
Compositional biasi | 530 – 554 | PolarSequence analysisAdd BLAST | 25 | |
Compositional biasi | 1123 – 1138 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1147 – 1162 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1163 – 1183 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1267 – 1293 | PolyampholyteSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1295 – 1333 | PolarSequence analysisAdd BLAST | 39 | |
Compositional biasi | 1353 – 1368 | Pro-richSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1399 – 1435 | PolyampholyteSequence analysisAdd BLAST | 37 | |
Compositional biasi | 1436 – 1485 | PolarSequence analysisAdd BLAST | 50 | |
Compositional biasi | 1507 – 1521 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1583 – 1669 | PolyampholyteSequence analysisAdd BLAST | 87 | |
Compositional biasi | 1675 – 1704 | Pro-richSequence analysisAdd BLAST | 30 | |
Compositional biasi | 1772 – 1790 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1830 – 1844 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1861 – 1876 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1877 – 1892 | PolyampholyteSequence analysisAdd BLAST | 16 |
Phylogenomic databases
GeneTreei | ENSGT00940000155237 |
InParanoidi | F7HG05 |
TreeFami | TF350731 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd15471, Myo5p-like_CBD_afadin, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037977, CBD_Afadin IPR002710, Dilute_dom IPR000253, FHA_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008984, SMAD_FHA_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00498, FHA, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 2 hits |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00240, FHA, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 2 hits |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 2 hits |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F7HG05-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAGGRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK
60 70 80 90 100
AAGNFATKCI RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG
110 120 130 140 150
EERRLDIDEK PLVVQLNWNK DDREGRFVLK NENDAIPPKK AQSNGPEKQE
160 170 180 190 200
KEGVIQNFKR TLSKKEKKEK KKREKEALRQ ASDKDDRPFQ GEDVENSRLA
210 220 230 240 250
AEVYKDMPET SFTRTISNPE VVMKRRRQQK LEKRMQEFRS SDGRPDSGGT
260 270 280 290 300
LRIYADSLKP NIPYKTILLS TTDPADFAVA EALEKYGLEK ENPKDYCIAR
310 320 330 340 350
VMLPPGAQHS DEKGAKEIIL DDDECPLQIF REWPSDKGIL VFQLKRRPPD
360 370 380 390 400
HIPKKTKKHL EGKTPKGKER ADGSGYGSAL PPEKLPYLVE LSPDGSDSRD
410 420 430 440 450
KPKLYRLQLS VTEVGTEKLD DSSIQLFGPG IQPHHCDLTN MDGVVTVTPR
460 470 480 490 500
SMDAETYVEG QRISETTMLQ SGMKVQFGAS HVFKFVDPTQ DHALAKRSVD
510 520 530 540 550
GGLMVKGPRH KPGIVQETTF DLGGDIHSGT ALPTSKSTTR LDSDRVSSAS
560 570 580 590 600
STAERGMVKP MIRVEQQPDY RRQESRTQDA SGPELILPAS IEFRESSEDS
610 620 630 640 650
FLSAIINYTN SSTVHFKLSP TYVLYMACRY VLSNQYRPDI SPTERTHKVI
660 670 680 690 700
AVVNKMVSMM EGVIQEVDQV DQKQKNIAGA LAFWMANASE LLNFIKQDRD
710 720 730 740 750
LSRITLDAQD VLAHLVQMAF KYLVHCLQSE LNNYMPAFLD DPEENSLQRP
760 770 780 790 800
KIDDVLHTLT GAMSLLRRCR VNAALTIQLF SQLFHFINMW LFNRLVTDPD
810 820 830 840 850
SGLCSHYWGA IIRQQLGHIE AWAEKQGLEL AADCHLSRIV QATTLLTMDK
860 870 880 890 900
YAPDDIPNIN STCFKLNSLQ LQALLQNYHC APDEPFIPTD LIENVVAVAE
910 920 930 940 950
NTADELARSD GREVQLEEDP DLQLPFLLPE DGYSCDVVRN IPNGLQEFLD
960 970 980 990 1000
PLCQRGFCRL IPHTRSPGTW TIYFEGADYE SHLLRENTEL AQPLRKEPEI
1010 1020 1030 1040 1050
ITVTLKKQNG MGLSIVAAKG AGQDKLGIYV KSVVKGGAAD VDGRLAAGDQ
1060 1070 1080 1090 1100
LLSVDGRSLV GLSQERAAEL MTRTSSVVTL EVAKQGAIYH GLATLLNQPS
1110 1120 1130 1140 1150
PMMQRISDRR GSGKPRPKSE GFELYNNSAQ NGSPESPQLP WAEYSEPKKL
1160 1170 1180 1190 1200
PGDDRLTKNR ADHRSSPNVA NQPPSPGGKS AYASGTAAKI TSVSTGNLCT
1210 1220 1230 1240 1250
EEQTPPPRPE AYPIPTQTYT REYFTFPASK SQDRMAPPQN QWPNYEEKPH
1260 1270 1280 1290 1300
MHTDSNHSSI AIQRVTRSQE ELREDKAYQL ERHRIEAAMD RKSDSDMWIN
1310 1320 1330 1340 1350
QSSSLDSSTS SQEHLNHSSK SVTPASTLTK SGPGRWKTPA AIPATPVAVS
1360 1370 1380 1390 1400
QPIRTDLPPP PPPPPVHYAG DFDGMSMDLP LPPPPSTNQI GLPSAQVAAA
1410 1420 1430 1440 1450
ERKKREEHQR WYEKEKARLE EERERKRREQ ERKLGQMRTQ SLNPAPFSPL
1460 1470 1480 1490 1500
TTQQMKPEKP STLQRPQETV IRELQPQQQP RTIERRDLQY ITVSKEELSS
1510 1520 1530 1540 1550
GDSLSPDPWK RDAKEKLEKQ QQMHIVDMLS KEIQELQSKP DRSAEESDRL
1560 1570 1580 1590 1600
RKLMLEWQFQ KRLQESKQKD EDDEEEEDDD VDTMLIMQRL EAERRARLQD
1610 1620 1630 1640 1650
EERRRQQQLE EMRKREAEDR ARQEEERRRQ EEERTKRDAE EKRRQEEGYY
1660 1670 1680 1690 1700
SRLEAERRRQ HDEAARRLLE PEAPGLCRPP LPRDYEPPSP SPAPGAPPPP
1710 1720 1730 1740 1750
PQRNASYLKT QVLSPDSLFT AKFVAYNEEE EEEDCSLAGQ DKYSSTRMSH
1760 1770 1780 1790 1800
GDLLPAPLKP RPPPCQPRPA SDGIFLSNSF QPSPAKANST AHKKGQPPPP
1810 1820 1830 1840 1850
PKKSSSYHPS HCKGPNSYPG SAGAAVGAHD AYRDAKEKRS KSQDADLPGS
1860 1870 1880 1890
SGAPENLTFK ERQRLFSQGQ DVSNKVKASR KLTELENELN TK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF7HG08 | F7HG08_MACMU | Afadin, adherens junction formation... | AFDN | 1,785 | Annotation score: | ||
F7HG07 | F7HG07_MACMU | Afadin, adherens junction formation... | AFDN | 1,844 | Annotation score: |
Genome annotation databases
Ensembli | ENSMMUT00000029596; ENSMMUP00000027697; ENSMMUG00000021044 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSMMUT00000029596; ENSMMUP00000027697; ENSMMUG00000021044 |
Organism-specific databases
VGNCi | VGNC:69818, AFDN |
Phylogenomic databases
GeneTreei | ENSGT00940000155237 |
InParanoidi | F7HG05 |
TreeFami | TF350731 |
Gene expression databases
Bgeei | ENSMMUG00000021044, Expressed in lung and 23 other tissues |
ExpressionAtlasi | F7HG05, baseline |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd15471, Myo5p-like_CBD_afadin, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037977, CBD_Afadin IPR002710, Dilute_dom IPR000253, FHA_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008984, SMAD_FHA_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00498, FHA, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 2 hits |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00240, FHA, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 2 hits |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 2 hits |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7HG05_MACMU | |
Accessioni | F7HG05Primary (citable) accession number: F7HG05 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 11, 2019 | |
Last modified: | February 10, 2021 | |
This is version 65 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |