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Protein

NEDD8-activating enzyme E1 regulatory subunit

Gene

NAE1

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.UniRule annotation

Pathwayi: protein neddylation

This protein is involved in the pathway protein neddylation, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein neddylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathwayUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00885

Names & Taxonomyi

Protein namesi
Recommended name:
NEDD8-activating enzyme E1 regulatory subunitUniRule annotation
Gene namesi
Name:NAE1Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 20

Expressioni

Gene expression databases

BgeeiENSMMUG00000006752
ExpressionAtlasiF7HD37 baseline

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 522ThiFInterPro annotationAdd BLAST510

Sequence similaritiesi

Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG2016 Eukaryota
COG0476 LUCA
GeneTreeiENSGT00550000074901

Family and domain databases

InterProiView protein in InterPro
IPR030667 APP-BP1
IPR000594 ThiF_NAD_FAD-bd
IPR035985 Ubiquitin-activating_enz
PANTHERiPTHR10953:SF29 PTHR10953:SF29, 1 hit
PfamiView protein in Pfam
PF00899 ThiF, 1 hit
PIRSFiPIRSF039099 APP-BP1, 1 hit
SUPFAMiSSF69572 SSF69572, 1 hit

Sequencei

Sequence statusi: Complete.

F7HD37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQPGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV
60 70 80 90 100
LPGIGSFTII DGNQVSGEDA GNKYFFLIQV KCFVFKKNRA EAAMEFLQEL
110 120 130 140 150
NSDVSGSFVE ESPENLLDND PSFFCRFTVV VATQLPESTL LRLADVLWNS
160 170 180 190 200
QIPLLICRTY GLVGYMRIII KEHPVIESHP DNALEDLRLD KPFPELREHF
210 220 230 240 250
QSYDLDHMEK KDHSHTPWIV IIAKYLAQWY SETNGRIPKT YKEKEDFRDL
260 270 280 290 300
IRQGILKNEN GAPEDEENFE EAIKNVNTAL NTTQIPSSIE DIFNDDRCIN
310 320 330 340 350
ITKQTPSFWI LARALKEFVA KEGQGNLPVR GTIPDMIADS GKYIKLQNVY
360 370 380 390 400
REKAKKDAAA VGNHVAKLLQ SIGQAPESIS EKELKLLCSN SAFLRVVRCR
410 420 430 440 450
SLAEEYGLDT INKDEIISSM DNPDNEIVLY LMLRAVDRFH KQHGRYPGVS
460 470 480 490 500
NYQVEEDIGK LKSCLTGFLQ EYGLSVMVKD DYVHEFCRYG AAEPHTIAAF
510 520 530
LGGAAAQEVI KIITKQFVIF NNTYIYSGMS QTSATFQL
Length:538
Mass (Da):60,907
Last modified:November 30, 2016 - v2
Checksum:iE45823394C4B8F83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03026430 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMMUT00000009450; ENSMMUP00000008883; ENSMMUG00000006752

Similar proteinsi

Entry informationi

Entry nameiF7HD37_MACMU
AccessioniPrimary (citable) accession number: F7HD37
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: November 30, 2016
Last modified: March 28, 2018
This is version 38 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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