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Entry version 63 (26 Feb 2020)
Sequence version 1 (27 Jul 2011)
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Protein
Submitted name:

DNA mismatch repair protein Mlh3 isoform 1

Gene

MLH3

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DNA mismatch repair protein Mlh3 isoform 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MLH3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca mulatta (Rhesus macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9544 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMMUG00000002911 Expressed in CD4-positive helper T cell and 13 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini211 – 349DNA_mis_repairInterPro annotationAdd BLAST139
Domaini1194 – 1375MutL_CInterPro annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni873 – 892DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi873 – 891PolyampholyteSequence analysisAdd BLAST19

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1977 Eukaryota
COG0323 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002376_0_0_1

KEGG Orthology (KO)

More...
KOi
K08739

Identification of Orthologs from Complete Genome Data

More...
OMAi
CNFFHNM

Database of Orthologous Groups

More...
OrthoDBi
735423at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329597

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.20, 1 hit
3.30.1370.100, 1 hit
3.30.230.10, 1 hit
3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014762 DNA_mismatch_repair_CS
IPR013507 DNA_mismatch_S5_2-like
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR028830 Mlh3
IPR038973 MutL/Mlh/Pms
IPR014790 MutL_C
IPR042120 MutL_C_dimsub
IPR042121 MutL_C_regsub
IPR037198 MutL_C_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr

The PANTHER Classification System

More...
PANTHERi
PTHR10073 PTHR10073, 1 hit
PTHR10073:SF47 PTHR10073:SF47, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01119 DNA_mis_repair, 1 hit
PF02518 HATPase_c, 1 hit
PF08676 MutL_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01340 DNA_mis_repair, 1 hit
SM00853 MutL_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF118116 SSF118116, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00058 DNA_MISMATCH_REPAIR_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F7HAZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIKCLSVEVQ AKLRSGLAIS SLGQCVEELA LNSIDAEAKC VAVRVNMETF
60 70 80 90 100
QVQVIDNGFG MGSDDVEKVG NRYFTSKCHS VQDLENPRFY GFRGEALANI
110 120 130 140 150
ADMASAVEIS SKKNRTMKTF VKLFQSGKAL KACEADVTRP SGGTTVTVYN
160 170 180 190 200
LFYQLPVRRK CMDPRLEFEK VRQRIEALSL MHPSISFSLR NDVSGSMVLQ
210 220 230 240 250
LPKTKDVCSR FCQIYGLGKS QKLREISFKY KQFELSGYIS SEAHYNKNMQ
260 270 280 290 300
FLFVNKRLVL RTKLHKLIDF LLRKESIICK PKNGSTSRQM SSSLRHRSTP
310 320 330 340 350
ELYGIYVINV QCQFCEYDVC MEPAKTLIEF QNWDTLLFCI QEGVKMFLKQ
360 370 380 390 400
EKLFVELSGE DIKEFSEDNG FNLFDATLQK RVTSDERSNQ GSFQEACNNI
410 420 430 440 450
LDSYEMFNLQ SKSVKRKATA ENISTQNSRD LEAIRKNTND AFLCIYESGG
460 470 480 490 500
PGHSKMTEPS LQNKDSSCSE SKMLEQETIV ASEAGENEKH KKSCLEHSSL
510 520 530 540 550
ENPCGTSSEM FLSPFQTPCH FEESGEDLEI WKESTTVNDM AANVMKNNRI
560 570 580 590 600
QNQPERFKDA TEVGCQPLPF ATTLLGVHSA QTEKEKKKEP SNCGGRNVFS
610 620 630 640 650
YGRVKLCSTG FITHIVQNEK TKSIETEHAF KNYVRPGPTR AQETFGNRTR
660 670 680 690 700
HSVETLDLKD LAGTLSRESG QLPNKKICRT NISCGLENEP TATYAKFSTF
710 720 730 740 750
QQDSKKSQTG CILSDTSPSF PWYRHVSNDS RKTDKLIGSS KPIVRKKLSL
760 770 780 790 800
SSQLGSLEKF KRQYGKVENP LDTEVEESNG VTTNLSPQVE PDILLKNKNC
810 820 830 840 850
LDNSDVCKIT TMKHSDSDSS CQPVSHVLDS EKLPFSKDED CLEQQMPSLR
860 870 880 890 900
ESPMTLKELS LFNRKPLDLE KSSESLASKL SRRKGSERET QTMEMMSRFN
910 920 930 940 950
ELPNSDSSRK ESKLCSVLTQ DFCMLFKNEH EKTENGVIPT SDSATQDISF
960 970 980 990 1000
NKNSKTHSNS NTTENCVISE TPLVLPYDNF KVTSKDSDVL IRASEQHTGS
1010 1020 1030 1040 1050
PDSPSGMLMN LVDDATGDQN GICFQSEESK ARACSETEES NTCCSNWQQH
1060 1070 1080 1090 1100
FDVALGRMVY VNKMTGLSTF IAPTEDIQTA CTKDLTTVAV DVVLENGSQY
1110 1120 1130 1140 1150
RCHPFRSDLV LPFLPRARAE RTVMRQDNRD TVDDTISSEL LQSLFSEWDN
1160 1170 1180 1190 1200
PVFARYPEVA VDVSSGQAES LAVKIHNILY PYRFTKEMIH SMQVLQQVDS
1210 1220 1230 1240 1250
KFIACLMSTK TEENGEAGGN LLVLVDQHAA HERIRLEQLI IDSYEKQQAQ
1260 1270 1280 1290 1300
GSGRKKLLSS TLIPPLEITV TEEQRRLLWC YHKNLEDLGL ELVFPDTSDS
1310 1320 1330 1340 1350
LVLVGKVPLC FVEREANELR RGRSTVTKSI VEEFIREQVE LLQTTGGIQG
1360 1370 1380 1390 1400
TLPLTVQKVL ASQACHGAIK FNDGLSLQES CRLIETLSSC QLPFQCAHGR
1410 1420 1430 1440 1450
PSMLPLADID HLEQEKQIKP NLAKLRKMAQ AWRLFGKAEC DTTQSLQQSM

PPCEPP
Length:1,456
Mass (Da):163,799
Last modified:July 27, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95D3DD0583275475
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JU333986 mRNA Translation: AFE77741.1

NCBI Reference Sequences

More...
RefSeqi
NP_001244712.1, NM_001257783.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
701482

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mcc:701482

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JU333986 mRNA Translation: AFE77741.1
RefSeqiNP_001244712.1, NM_001257783.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi701482
KEGGimcc:701482

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27030

Phylogenomic databases

eggNOGiKOG1977 Eukaryota
COG0323 LUCA
HOGENOMiCLU_002376_0_0_1
KOiK08739
OMAiCNFFHNM
OrthoDBi735423at2759
TreeFamiTF329597

Gene expression databases

BgeeiENSMMUG00000002911 Expressed in CD4-positive helper T cell and 13 other tissues

Family and domain databases

Gene3Di2.30.42.20, 1 hit
3.30.1370.100, 1 hit
3.30.230.10, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR014762 DNA_mismatch_repair_CS
IPR013507 DNA_mismatch_S5_2-like
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR028830 Mlh3
IPR038973 MutL/Mlh/Pms
IPR014790 MutL_C
IPR042120 MutL_C_dimsub
IPR042121 MutL_C_regsub
IPR037198 MutL_C_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10073 PTHR10073, 1 hit
PTHR10073:SF47 PTHR10073:SF47, 1 hit
PfamiView protein in Pfam
PF01119 DNA_mis_repair, 1 hit
PF02518 HATPase_c, 1 hit
PF08676 MutL_C, 1 hit
SMARTiView protein in SMART
SM01340 DNA_mis_repair, 1 hit
SM00853 MutL_C, 1 hit
SUPFAMiSSF118116 SSF118116, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00058 DNA_MISMATCH_REPAIR_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7HAZ3_MACMU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7HAZ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: February 26, 2020
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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