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Entry version 49 (03 Jul 2019)
Sequence version 2 (30 Nov 2016)
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Protein
Submitted name:

Uncharacterized protein

Gene

CR2

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CR2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca mulatta (Rhesus macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9544 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006718 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:71479 CR2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1033 – 1058HelicalSequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500895716321 – 1093Sequence analysisAdd BLAST1073

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi155 ↔ 198PROSITE-ProRule annotation
Disulfide bondi184 ↔ 211PROSITE-ProRule annotation
Disulfide bondi380 ↔ 407PROSITE-ProRule annotation
Disulfide bondi411 ↔ 454PROSITE-ProRule annotation
Disulfide bondi440 ↔ 467PROSITE-ProRule annotation
Disulfide bondi496 ↔ 523PROSITE-ProRule annotation
Disulfide bondi631 ↔ 658PROSITE-ProRule annotation
Disulfide bondi662 ↔ 705PROSITE-ProRule annotation
Disulfide bondi691 ↔ 718PROSITE-ProRule annotation
Disulfide bondi779 ↔ 822PROSITE-ProRule annotation
Disulfide bondi876 ↔ 903PROSITE-ProRule annotation
Disulfide bondi911 ↔ 954PROSITE-ProRule annotation
Disulfide bondi940 ↔ 967PROSITE-ProRule annotation
Disulfide bondi972 ↔ 1015PROSITE-ProRule annotation
Disulfide bondi1001 ↔ 1028PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMMUG00000013602 Expressed in 10 organ(s), highest expression level in spleen

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9544.ENSMMUP00000017894

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 84SushiInterPro annotationAdd BLAST64
Domaini89 – 149SushiInterPro annotationAdd BLAST61
Domaini153 – 213SushiInterPro annotationAdd BLAST61
Domaini214 – 274SushiInterPro annotationAdd BLAST61
Domaini275 – 345SushiInterPro annotationAdd BLAST71
Domaini350 – 408SushiInterPro annotationAdd BLAST59
Domaini409 – 469SushiInterPro annotationAdd BLAST61
Domaini470 – 525SushiInterPro annotationAdd BLAST56
Domaini526 – 596SushiInterPro annotationAdd BLAST71
Domaini601 – 659SushiInterPro annotationAdd BLAST59
Domaini660 – 720SushiInterPro annotationAdd BLAST61
Domaini739 – 776SushiInterPro annotationAdd BLAST38
Domaini777 – 841SushiInterPro annotationAdd BLAST65
Domaini846 – 905SushiInterPro annotationAdd BLAST60
Domaini909 – 969SushiInterPro annotationAdd BLAST61
Domaini970 – 1030SushiInterPro annotationAdd BLAST61

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KDF5 Eukaryota
ENOG410YE3Q LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161110

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7GSR2

KEGG Orthology (KO)

More...
KOi
K04012

Database of Orthologous Groups

More...
OrthoDBi
46968at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316872

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 14 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00084 Sushi, 14 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57535 SSF57535, 16 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923 SUSHI, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F7GSR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAAGLLGVF LALIVPGVLG ISCGSPPPIL NGRISHYSTP ITLGTVIRYI
60 70 80 90 100
CSNGFRLIGE KNIICITKDK VVGIWDKPAP KCEYFNKYST CPEPIVPGGY
110 120 130 140 150
KARGAEPPYI HGDFVTFACK TNFSMNGNKS VWCQANNKWG PTRLPTCESV
160 170 180 190 200
FPLECPALPM IHNGHHTREN VGSIAPGLSV TYSCESGYLL VGEKIINCLS
210 220 230 240 250
SGKWSAVPPT CEEARCKPLG RFPNGKVKEP PILQVGVTAN FFCDEGYQLQ
260 270 280 290 300
GPSSSRCVIA GQGVAWTKMP VCKEIFCPSP PPILNGRHTG NSLANVSYGS
310 320 330 340 350
IVTYTCDPDP EEGVNFILIG ENTLRCTVDS QKTGTWSGPA PRCELSTSAV
360 370 380 390 400
QCPRPQVLRG RIVSGQKDRY TYNDTVIFAC TFGFTLKGSK QIRCNAQGTW
410 420 430 440 450
EPSAPVCEKE CQAPPNILNG QKEDRHMVRF NPGTSIKYSC NPGYVLVREE
460 470 480 490 500
SIQCTSEGVW TPPVPQCKVA VCEATGKQLL TKPQHQFIRP DVNSSCDEGY
510 520 530 540 550
KLSGSVYQEC QGRTPWFMEI RLCKEITCPP PPVIYNGAHT GSSLEDFPYG
560 570 580 590 600
TTVTYTCNPG PEREVEFSLI GESTIRCTSN DQERGTWSGP APLCELSLLA
610 620 630 640 650
VQCSHVHVAN GYKISGKEAP YFYNDTVTFK CFNGFTLKGS SQIRCKANNT
660 670 680 690 700
WDPEIPVCEK GCQPPPGLHH GRHTGGNTVF FVSGMTVDYT CDPGYLLVGN
710 720 730 740 750
KSIHCMPSGN WSPSAPRCEE TCQPVREDLQ ELPVGSRVEL VNTSCQDGYW
760 770 780 790 800
LTGHTYHKCK DDENGIWFKK IPLCKVIHCH PPPVIVNGKH TGMKAENFLY
810 820 830 840 850
GNEVSYECDQ GFYLLGEKKL QCRSDSKGHG SWSGPSPQCL QSPPVTSCPN
860 870 880 890 900
PEVKHGYKLN KTLSAYSHDD IVYVDCHPGF IMNGSRVIRC HTDNTWVPGV
910 920 930 940 950
PTCIKKAFVG CQPPPKTPNG NHTGGNIARF SPGMSILYSC DQGYLLVGEA
960 970 980 990 1000
LLLCTHEGTW NRPAPHCKEV NCSSPADMDG IQKGLEPRKM YQYGAVVTLE
1010 1020 1030 1040 1050
CEDGYMLEGS SQSQCQADHQ WNPPLAVCRS RSLAPVLSGI AAGLILLIFL
1060 1070 1080 1090
IVVTLCMISK HRERNYHTNT SQKEAFRLEA REVYSIDPYN PAS
Length:1,093
Mass (Da):119,803
Last modified:November 30, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E33DD1300A8A96E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7GSQ8F7GSQ8_MACMU
Uncharacterized protein
CR2
972Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JSUE03002942 Genomic DNA No translation available.
JSUE03002943 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_014973177.1, XM_015117691.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMMUT00000019104; ENSMMUP00000017894; ENSMMUG00000013602

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
714202

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mcc:714202

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03002942 Genomic DNA No translation available.
JSUE03002943 Genomic DNA No translation available.
RefSeqiXP_014973177.1, XM_015117691.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000017894

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000019104; ENSMMUP00000017894; ENSMMUG00000013602
GeneIDi714202
KEGGimcc:714202

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1380
VGNCiVGNC:71479 CR2

Phylogenomic databases

eggNOGiENOG410KDF5 Eukaryota
ENOG410YE3Q LUCA
GeneTreeiENSGT00940000161110
InParanoidiF7GSR2
KOiK04012
OrthoDBi46968at2759
TreeFamiTF316872

Gene expression databases

BgeeiENSMMUG00000013602 Expressed in 10 organ(s), highest expression level in spleen

Family and domain databases

CDDicd00033 CCP, 14 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 14 hits
SMARTiView protein in SMART
SM00032 CCP, 15 hits
SUPFAMiSSF57535 SSF57535, 16 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 16 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7GSR2_MACMU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7GSR2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: November 30, 2016
Last modified: July 3, 2019
This is version 49 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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