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Protein
Submitted name:

Uncharacterized protein

Gene

LOC100428435

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:LOC100428435Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei230 – 252HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500895702430 – 268Sequence analysisAdd BLAST239

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMMUG00000029799 Expressed in 14 organ(s), highest expression level in peripheral blood mononuclear cell
ExpressionAtlasiF7G8K4 baseline

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 216Ig-likeInterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the MHC class II family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00900000140849

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

F7G8K4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVCLKLHGGS CMAALTVTLM VLSSPLALAG DTQSRFLEQV KFECHFFNGT
60 70 80 90 100
ERVRYLERRV HNQEEYARFD SDVGEYRAVT ELGRPDAEYW NGQKDLLERR
110 120 130 140 150
RAEVDTVCRH NYGVVESFTV QRRGELQPKV TVYPAKTQPL QHHNLLVCSV
160 170 180 190 200
SGFYPGSIEV RWFRNGQEEK AGVVSTGLIQ NGDWTFQTLV MLETVPRSGE
210 220 230 240 250
VYTCQVEHPS VTSPLTVEWR ARSESAQSKM LSGVGGFVLG LLFLGAGLFI
260
YFRNQKGHSG LQPTGNTF
Length:268
Mass (Da):30,158
Last modified:November 30, 2016 - v2
Checksum:i6C61F1ED122AD0B5
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6EWJ8Q6EWJ8_MACMU
MHC class II antigen
DRB1 LOC100428435
266Annotation score:
F7HNG4F7HNG4_MACMU
Uncharacterized protein
LOC100428435
270Annotation score:
F7GF62F7GF62_MACMU
Uncharacterized protein
LOC100428435
267Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03030660 Genomic DNA No translation available.
JSUE03030661 Genomic DNA No translation available.
JSUE03030662 Genomic DNA No translation available.
JSUE03030663 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMMUT00000032059; ENSMMUP00000029996; ENSMMUG00000029799

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03030660 Genomic DNA No translation available.
JSUE03030661 Genomic DNA No translation available.
JSUE03030662 Genomic DNA No translation available.
JSUE03030663 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000032059; ENSMMUP00000029996; ENSMMUG00000029799

Phylogenomic databases

GeneTreeiENSGT00900000140849

Gene expression databases

BgeeiENSMMUG00000029799 Expressed in 14 organ(s), highest expression level in peripheral blood mononuclear cell
ExpressionAtlasiF7G8K4 baseline

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF7G8K4_MACMU
AccessioniPrimary (citable) accession number: F7G8K4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: November 30, 2016
Last modified: September 12, 2018
This is version 42 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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