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Entry version 56 (02 Jun 2021)
Sequence version 2 (11 Dec 2019)
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Protein
Submitted name:

Zinc finger homeobox 3

Gene

ZFHX3

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi2148 – 2207HomeoboxPROSITE-ProRule annotationAdd BLAST60
DNA bindingi2245 – 2304HomeoboxPROSITE-ProRule annotationAdd BLAST60
DNA bindingi2653 – 2712HomeoboxPROSITE-ProRule annotationAdd BLAST60
DNA bindingi2958 – 3017HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger homeobox 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFHX3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri13616 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002280 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMODG00000002600, Expressed in forelimb bud and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
13616.ENSMODP00000003157

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini730 – 759C2H2-typeInterPro annotationAdd BLAST30
Domaini1361 – 1391C2H2-typeInterPro annotationAdd BLAST31
Domaini1402 – 1424C2H2-typeInterPro annotationAdd BLAST23
Domaini1546 – 1577C2H2-typeInterPro annotationAdd BLAST32
Domaini1597 – 1626C2H2-typeInterPro annotationAdd BLAST30
Domaini1985 – 2013C2H2-typeInterPro annotationAdd BLAST29
Domaini2146 – 2206HomeoboxInterPro annotationAdd BLAST61
Domaini2243 – 2303HomeoboxInterPro annotationAdd BLAST61
Domaini2331 – 2360C2H2-typeInterPro annotationAdd BLAST30
Domaini2542 – 2564C2H2-typeInterPro annotationAdd BLAST23
Domaini2651 – 2711HomeoboxInterPro annotationAdd BLAST61
Domaini2723 – 2753C2H2-typeInterPro annotationAdd BLAST31
Domaini2956 – 3016HomeoboxInterPro annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 79DisorderedSequence analysisAdd BLAST79
Regioni103 – 127DisorderedSequence analysisAdd BLAST25
Regioni417 – 542DisorderedSequence analysisAdd BLAST126
Regioni587 – 619DisorderedSequence analysisAdd BLAST33
Regioni1160 – 1218DisorderedSequence analysisAdd BLAST59
Regioni1299 – 1354DisorderedSequence analysisAdd BLAST56
Regioni1491 – 1530DisorderedSequence analysisAdd BLAST40
Regioni1631 – 1715DisorderedSequence analysisAdd BLAST85
Regioni1869 – 1940DisorderedSequence analysisAdd BLAST72
Regioni2032 – 2085DisorderedSequence analysisAdd BLAST54
Regioni2226 – 2245DisorderedSequence analysisAdd BLAST20
Regioni2379 – 2398DisorderedSequence analysisAdd BLAST20
Regioni2414 – 2519DisorderedSequence analysisAdd BLAST106
Regioni2632 – 2659DisorderedSequence analysisAdd BLAST28
Regioni2853 – 2886DisorderedSequence analysisAdd BLAST34
Regioni2924 – 2959DisorderedSequence analysisAdd BLAST36
Regioni3149 – 3271DisorderedSequence analysisAdd BLAST123
Regioni3393 – 3470DisorderedSequence analysisAdd BLAST78
Regioni3583 – 3706DisorderedSequence analysisAdd BLAST124

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1728 – 1751Sequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi16 – 49Polar residuesSequence analysisAdd BLAST34
Compositional biasi417 – 432Polar residuesSequence analysisAdd BLAST16
Compositional biasi435 – 456Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi457 – 495Acidic residuesSequence analysisAdd BLAST39
Compositional biasi496 – 515Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi524 – 542Polar residuesSequence analysisAdd BLAST19
Compositional biasi1167 – 1186Polar residuesSequence analysisAdd BLAST20
Compositional biasi1193 – 1208Polar residuesSequence analysisAdd BLAST16
Compositional biasi1637 – 1689Polar residuesSequence analysisAdd BLAST53
Compositional biasi1878 – 1925Basic and acidic residuesSequence analysisAdd BLAST48
Compositional biasi2035 – 2080Pro residuesSequence analysisAdd BLAST46
Compositional biasi2228 – 2245Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi2444 – 2487Polar residuesSequence analysisAdd BLAST44
Compositional biasi2488 – 2507Pro residuesSequence analysisAdd BLAST20
Compositional biasi2924 – 2946Polar residuesSequence analysisAdd BLAST23
Compositional biasi3149 – 3164Polar residuesSequence analysisAdd BLAST16
Compositional biasi3172 – 3209Polar residuesSequence analysisAdd BLAST38
Compositional biasi3218 – 3235Polar residuesSequence analysisAdd BLAST18
Compositional biasi3236 – 3264Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi3399 – 3428Pro residuesSequence analysisAdd BLAST30
Compositional biasi3432 – 3446Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi3597 – 3614Polar residuesSequence analysisAdd BLAST18
Compositional biasi3633 – 3661Polar residuesSequence analysisAdd BLAST29

Keywords - Domaini

Coiled coilSequence analysis, HomeoboxPROSITE-ProRule annotationARBA annotation, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1146, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156149

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000245_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7G4V9

TreeFam database of animal gene trees

More...
TreeFami
TF323288

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046, Homeodomain, 4 hits
PF00096, zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389, HOX, 4 hits
SM00355, ZnF_C2H2, 23 hits
SM00451, ZnF_U1, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 4 hits
SSF57667, SSF57667, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027, HOMEOBOX_1, 2 hits
PS50071, HOMEOBOX_2, 4 hits
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

F7G4V9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGCDSPVIP GKDNGCSIPQ HQQWTELNST HLPDKPSSME QSTTENHGPL
60 70 80 90 100
DSLRAPFNER LPDSTNSAGP AAEPASKEVS CNECSTSFAS LQTYMEHHCP
110 120 130 140 150
IARPPLPLRE ESGSDTSEEG DEESDVENLA GEIVYQPDGS AYIVESVSQL
160 170 180 190 200
IQSGGACGSG SGALPSLFLN SLPSAGGKQG DPSSAAPVYP QIINTFHIAS
210 220 230 240 250
SFGKWFEGSD QAFPNTSALT GISPVLHSFR VFDVRHKSNK DYLNSDGSAK
260 270 280 290 300
SSCVSKDVPN NVDLSKFDGF VLYGKRKPIL MCFLCKLSFG YVRSFVTHAV
310 320 330 340 350
HDHRMTLSEE ERKILSNKNI SAIIQGIGKD KEPLVSFLEP KNKNFQHPLV
360 370 380 390 400
SAANLIGPGH SFYGKFSGIR MEGEEALQGA ATGAAAAEQP QSGLLTPGTL
410 420 430 440 450
LNLGGLTSSA LKTPITSVPL GPLASSPTKS SEGKDPGGAE GEKQEAGDQD
460 470 480 490 500
SLSEKAEPAE DVEEEEEEEE EEDAEEEEEE EEEEEEEEEE EDEGCKGLFP
510 520 530 540 550
SELEDELEDR PHEESGAMAG GSNKNDLALS NQSISNSPLM PNMLHTLSRS
560 570 580 590 600
AASTSSNSTS SFVVFDGANR RNRLSFNSEG VRANVAEGSK RLDLMDESAN
610 620 630 640 650
KDNATVPEPN ESAEGEDGGY LPHHQHAGAL CELGVGECPS GSGVECPKCD
660 670 680 690 700
TVLGSSRSLG GHMTMMHSRN SCKTLKCPKC NWHYKYQQTL EAHMKEKHPE
710 720 730 740 750
PGGSCVYCKS GQPHPRLARG ESYTCGYKPF RCEVCNYSTT TKGNLSIHMQ
760 770 780 790 800
SDKHLNNMQN LQNGGGEQVF SHSAGAAAAA AAAAAAAANL GSSCGAPSPT
810 820 830 840 850
KPKTKPTWRC EVCDYETNVA RNLRIHMTSE KHMHNMMLLQ QNMTQIQHNR
860 870 880 890 900
HLGLGALPSP AEAELYQYYL AQNMTLPNLK MDSPASDAQF MMSGFQLDPT
910 920 930 940 950
SPMTAMTTPA LVGGEIPLDM RLGGGQLVSE ELMNLGESFT QTNDPSLKLF
960 970 980 990 1000
QCAVCNKFTT DSLDLLGLHM NMERGLPEEE WKAVMGDSYQ CKLCRYNTQL
1010 1020 1030 1040 1050
KANFQLHCKT DKHVQKYQLV AHIKEGGKAN EWRLKCVAIG NPVHLKCNAC
1060 1070 1080 1090 1100
DYYTNSLEKL RLHTVNSRHE ASLKLYKHLQ QHETGVEGES CYYHCVLCNY
1110 1120 1130 1140 1150
STKAKLNLIQ HVRSMKHQRS ESLRKLQRLQ KGLPEEEEDL GQIFTIRKCP
1160 1170 1180 1190 1200
ATDPGEWPLS GPELASYSGS ELESRQASSS QADKELPDCP ATSKRTSFPS
1210 1220 1230 1240 1250
SSEPPLSSKR PKTSEEAKSE QMFQCPYCKY SNADVNRLRV HAMTQHSVQP
1260 1270 1280 1290 1300
MLRCPLCQDM LNNKIHLQLH LTHLHSVAPD CVEKLIMTVT TPEMMMPSSM
1310 1320 1330 1340 1350
FLPATVPDRD GSSNPEEAGK QPETSEDLGK SVLPASESAE HSGELKPSPA
1360 1370 1380 1390 1400
DPGSAREESG FLCWKKGCNQ VFKTSSALQT HFNEVHAKRP QLPVSDRHVY
1410 1420 1430 1440 1450
KYRCNQCSLA FKTVEKLQLH SQYHVIRAAT MCCLCQRSFR TFQALKKHLE
1460 1470 1480 1490 1500
TSHLELSEAD IQQLYSGLLV NGDLLAMGDP SLAEDHTIIV EEDKEEESDL
1510 1520 1530 1540 1550
EDKQSPTGSD SGSVQEDSGS EPKRALPFRK GPNFTMEKFL DPSRPYKCTV
1560 1570 1580 1590 1600
CKESFTQKNI LLVHYNSVSH LHKLKRALQE SATGQPEPTS SPDNKPFKCN
1610 1620 1630 1640 1650
TCNVAYSQSS TLEIHMRSVL HQTKARAAKL EAAGSGGASN GTGNSNSLSL
1660 1670 1680 1690 1700
GASAPSPVNT SGGGNAFPTT SAGSAGAAPS SSLLSQAPSD SVGMPPLGNP
1710 1720 1730 1740 1750
MGANLASPSE PKEVNRKKLA DMIASRQQQQ AQQQQQQQQQ QAQTLAQAQA
1760 1770 1780 1790 1800
QVQAHLQQEL QQQAALIQSQ LFNPALLPHF PMTTETLLQL QQQQHLLFPF
1810 1820 1830 1840 1850
YIPSAEFQLN PDVSLPVTSG ASLTLTGAGP TLLEDLKAQV QIPQQSHQQI
1860 1870 1880 1890 1900
LQQQQQSQLS LSQAHTAALL PQGQHPEKKN KAVVKEKDKD SQRERENVER
1910 1920 1930 1940 1950
GDGNAGSKES HPDALKPKDK KDFAPGGGSE PSMLPPRIAS DARGNATKAL
1960 1970 1980 1990 2000
LENFGFELVI QYNENKQKVQ KKSGKVEPGD SLEKLECESC GKLFSNILIL
2010 2020 2030 2040 2050
KSHQEHVHQN YFPFKQLERF AKQYREHYDK LYPLRPQTPE PPPPPPPPPP
2060 2070 2080 2090 2100
PPPLPAAPPQ PASTPTLPTP APPITSPTIA PAQPSVPLTQ LSMPMELPIF
2110 2120 2130 2140 2150
SPLMMQTMPL QTLPAQLPPQ LGPVDPLPAD LAQLYQHQLN PSLLQQQNKR
2160 2170 2180 2190 2200
PRTRITDDQL RVLRQYFDIN NSPSEEQIKE MADKSGLPQK VIKHWFRNTL
2210 2220 2230 2240 2250
FKERQRNKDS PYNFSNPPIT SLEELKIDSR PPSPEPQKHE YWGSKRSSRT
2260 2270 2280 2290 2300
RFTDYQLRVL QDFFDANAYP KDDEFEQLSN LLNLPTRVIV VWFQNARQKA
2310 2320 2330 2340 2350
RKNYENQGEG KDGERRELTN DRYIRTSNLN YQCKKCNLVF QRIFDLIKHQ
2360 2370 2380 2390 2400
KKLCYKDEDE DGQDDSQNED SMDALELLTP TSSSCSTPMP SQAYSAPASS
2410 2420 2430 2440 2450
ANATASSTFL QLTTEADESS TFGSKMEATD EKPKQPEPPS SQPNQTPEKQ
2460 2470 2480 2490 2500
VQPKHESQQQ QQPPPPQQDQ LEQKTNMAPQ KNPQLSSPPV LQQPPQQVPP
2510 2520 2530 2540 2550
PQCALPQSSP SPSSQLSHLS LKPLHTSTPQ QLANLPPQLI PYQCDQCKLA
2560 2570 2580 2590 2600
FPSFEHWQEH QQLHFLSAQN QFIHPQFLDR TLDMPFMLFD PSNPLLASQL
2610 2620 2630 2640 2650
LSGALPQVPA SSATSPSTPT STMNTLKRKL EEKASASPGE NDSGTGGEEP
2660 2670 2680 2690 2700
QRDKRLRTTI TPEQLEILYQ KYLLDSNPTR KMLDHIAHEV GLKKRVVQVW
2710 2720 2730 2740 2750
FQNTRARERK GQFRAVGPAQ AHRRCPFCRA LFKAKTALEA HIRSRHWHEA
2760 2770 2780 2790 2800
KRAGYNLTLS AMLLDCDGGI QMKGDIFDGS GFSHLPPSSS DGQGVPLSPV
2810 2820 2830 2840 2850
SKTMELSPRT LLSPSSIKVE GIEDFESPSM SSVNLNFDQT KLDNDDCSSV
2860 2870 2880 2890 2900
NTAITDTTTG DEGNADNDSA TGIATETKSS SAPNEGLTKA AMMAMSEYED
2910 2920 2930 2940 2950
RLSSGLVSPA PSFYSKEYDN EGTVDYSETS SLADPCSPSP GASGSAGKSG
2960 2970 2980 2990 3000
DSGDRPGQKR FRTQMTNLQL KVLKSCFNDY RTPTMLECEV LGNDIGLPKR
3010 3020 3030 3040 3050
VVQVWFQNAR AKEKKSKLSM AKHFGINQTS YEGPKTECTL CGIKYSARLS
3060 3070 3080 3090 3100
VRDHIFSQQH ISKVKDTIGS QLDKEKEYFD PATVRQLMAQ QELDRIKKAN
3110 3120 3130 3140 3150
EVLGLAAQQP GMFDNPPLQA LNLPTAYPAL QGIPPVLLPG LNSPSLPSFT
3160 3170 3180 3190 3200
PSNTALTSPK PNLMGLPGTT VPSPGLPTSG LPNKQSSASL SSPTPAQATM
3210 3220 3230 3240 3250
AMTPQQPPQP QQQQQQPPPP TQQQQQQQQQ QPPQQQRKDK EVEKMKEKEK
3260 3270 3280 3290 3300
AHKGKGETLA GPKKDKGEAP AATLSAPLPT MEYAVDPTQL QALQAALTSD
3310 3320 3330 3340 3350
PTALLTSQFL PYFVPGFSPY YAPQIPGALQ SGYLQPMYGM EGLFPYSPAL
3360 3370 3380 3390 3400
SQALMGLSPG SLLQQYQQYQ QLQQQQQQQQ QQQQQQQQQQ QKVQQQQQQQ
3410 3420 3430 3440 3450
QPPPPPAPQQ QPQPPKTSQT PVPPGAASPD KDPAKESPKQ EEQKSAPREV
3460 3470 3480 3490 3500
SPLLPKPPEE PEAESKSVDS LSDPFIVPKV QYKLVCRKCG ASFGDEEAAT
3510 3520 3530 3540 3550
SHLKSLCFLG QAAASLQEMV LHVPTGGGGG GGGSVGGSSG GGSGGPYHCL
3560 3570 3580 3590 3600
ACESTLCGDE ALSQHLESTL HKHRTITRAA RNAKEHPSLL PHSACFPGPS
3610 3620 3630 3640 3650
TASTSQSAAH SNDSPPKSWP PGVPRASVGK PASFPPLSSS STVTSSSCST
3660 3670 3680 3690 3700
SGVQPSMPTD DYSEESDTDL SQKSEGPASP AEGPPAPSCP PQDPGLASVG

MDPFRL
Length:3,706
Mass (Da):405,078
Last modified:December 11, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8971B2EB67328C5C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F8H1X3A0A5F8H1X3_MONDO
Zinc finger homeobox 3
ZFHX3
2,243Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8G9V9A0A5F8G9V9_MONDO
Zinc finger homeobox 3
ZFHX3
3,698Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8H0F4A0A5F8H0F4_MONDO
Zinc finger homeobox 3
ZFHX3
3,720Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMODT00000003225; ENSMODP00000003157; ENSMODG00000002600

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi13616.ENSMODP00000003157

Genome annotation databases

EnsembliENSMODT00000003225; ENSMODP00000003157; ENSMODG00000002600

Phylogenomic databases

eggNOGiKOG1146, Eukaryota
GeneTreeiENSGT00940000156149
HOGENOMiCLU_000245_0_0_1
InParanoidiF7G4V9
TreeFamiTF323288

Gene expression databases

BgeeiENSMODG00000002600, Expressed in forelimb bud and 21 other tissues

Family and domain databases

CDDicd00086, homeodomain, 4 hits
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00046, Homeodomain, 4 hits
PF00096, zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00389, HOX, 4 hits
SM00355, ZnF_C2H2, 23 hits
SM00451, ZnF_U1, 7 hits
SUPFAMiSSF46689, SSF46689, 4 hits
SSF57667, SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 2 hits
PS50071, HOMEOBOX_2, 4 hits
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 9 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7G4V9_MONDO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7G4V9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: June 2, 2021
This is version 56 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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