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Entry version 55 (07 Oct 2020)
Sequence version 3 (11 Dec 2019)
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Protein

Histone-lysine N-methyltransferase

Gene

KMT2A

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei3871S-adenosyl-L-methionineUniRule annotation1
Binding sitei3873S-adenosyl-L-methionineUniRule annotation1
Binding sitei3915S-adenosyl-L-methionineUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi3941ZincUniRule annotation1
Metal bindingi3989ZincUniRule annotation1
Binding sitei3990S-adenosyl-L-methionineUniRule annotation1
Metal bindingi3991ZincUniRule annotation1
Metal bindingi3996ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1179 – 1227CXXC-typePROSITE-ProRule annotationAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulatorUniRule annotationARBA annotation, DNA-bindingARBA annotation, MethyltransferaseUniRule annotationARBA annotation, Transferase
Biological processTranscription, Transcription regulationUniRule annotationARBA annotation
LigandMetal-binding, S-adenosyl-L-methionineUniRule annotationARBA annotation, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseUniRule annotation (EC:2.1.1.354UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KMT2AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca mulatta (Rhesus macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9544 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006718 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMMUG00000005482, Expressed in brain and 23 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1179 – 1227CXXC-typeInterPro annotationAdd BLAST49
Domaini1463 – 1514PHD-typeInterPro annotationAdd BLAST52
Domaini1511 – 1565PHD-typeInterPro annotationAdd BLAST55
Domaini1598 – 1659PHD-typeInterPro annotationAdd BLAST62
Domaini1735 – 1780BromoInterPro annotationAdd BLAST46
Domaini1902 – 2010PHD-typeInterPro annotationAdd BLAST109
Domaini2050 – 2106FYR N-terminalInterPro annotationAdd BLAST57
Domaini3698 – 3779FYR C-terminalInterPro annotationAdd BLAST82
Domaini3861 – 3977SETInterPro annotationAdd BLAST117
Domaini3985 – 4001Post-SETInterPro annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 80DisorderedSequence analysisAdd BLAST80
Regioni188 – 282DisorderedSequence analysisAdd BLAST95
Regioni357 – 378DisorderedSequence analysisAdd BLAST22
Regioni478 – 619DisorderedSequence analysisAdd BLAST142
Regioni745 – 981DisorderedSequence analysisAdd BLAST237
Regioni1070 – 1099DisorderedSequence analysisAdd BLAST30
Regioni1137 – 1197DisorderedSequence analysisAdd BLAST61
Regioni1232 – 1407DisorderedSequence analysisAdd BLAST176
Regioni1695 – 1745DisorderedSequence analysisAdd BLAST51
Regioni1838 – 1901DisorderedSequence analysisAdd BLAST64
Regioni2113 – 2165DisorderedSequence analysisAdd BLAST53
Regioni2177 – 2255DisorderedSequence analysisAdd BLAST79
Regioni2307 – 2367DisorderedSequence analysisAdd BLAST61
Regioni2405 – 2491DisorderedSequence analysisAdd BLAST87
Regioni2510 – 2650DisorderedSequence analysisAdd BLAST141
Regioni2679 – 2706DisorderedSequence analysisAdd BLAST28
Regioni2745 – 2853DisorderedSequence analysisAdd BLAST109
Regioni2995 – 3096DisorderedSequence analysisAdd BLAST102
Regioni3198 – 3277DisorderedSequence analysisAdd BLAST80
Regioni3496 – 3518DisorderedSequence analysisAdd BLAST23
Regioni3532 – 3639DisorderedSequence analysisAdd BLAST108
Regioni3651 – 3675DisorderedSequence analysisAdd BLAST25
Regioni3817 – 3840DisorderedSequence analysisAdd BLAST24
Regioni3938 – 3939S-adenosyl-L-methionine bindingUniRule annotation2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili406 – 426Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi37 – 58Pro-richSequence analysisAdd BLAST22
Compositional biasi217 – 236PolarSequence analysisAdd BLAST20
Compositional biasi237 – 259PolyampholyteSequence analysisAdd BLAST23
Compositional biasi358 – 378PolyampholyteSequence analysisAdd BLAST21
Compositional biasi478 – 528PolarSequence analysisAdd BLAST51
Compositional biasi568 – 588PolarSequence analysisAdd BLAST21
Compositional biasi589 – 608Pro-richSequence analysisAdd BLAST20
Compositional biasi745 – 763PolarSequence analysisAdd BLAST19
Compositional biasi779 – 877PolarSequence analysisAdd BLAST99
Compositional biasi878 – 930PolyampholyteSequence analysisAdd BLAST53
Compositional biasi1078 – 1093PolarSequence analysisAdd BLAST16
Compositional biasi1281 – 1304PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1310 – 1333PolarSequence analysisAdd BLAST24
Compositional biasi1334 – 1349Pro-richSequence analysisAdd BLAST16
Compositional biasi1854 – 1879Pro-richSequence analysisAdd BLAST26
Compositional biasi2128 – 2150PolarSequence analysisAdd BLAST23
Compositional biasi2178 – 2206PolarSequence analysisAdd BLAST29
Compositional biasi2221 – 2255PolarSequence analysisAdd BLAST35
Compositional biasi2307 – 2352PolarSequence analysisAdd BLAST46
Compositional biasi2434 – 2450PolarSequence analysisAdd BLAST17
Compositional biasi2451 – 2477PolyampholyteSequence analysisAdd BLAST27
Compositional biasi2558 – 2592PolarSequence analysisAdd BLAST35
Compositional biasi2599 – 2626PolarSequence analysisAdd BLAST28
Compositional biasi2753 – 2778PolarSequence analysisAdd BLAST26
Compositional biasi2779 – 2816PolyampholyteSequence analysisAdd BLAST38
Compositional biasi2817 – 2853PolarSequence analysisAdd BLAST37
Compositional biasi3043 – 3096PolarSequence analysisAdd BLAST54
Compositional biasi3198 – 3215PolarSequence analysisAdd BLAST18
Compositional biasi3227 – 3254PolarSequence analysisAdd BLAST28
Compositional biasi3262 – 3277PolarSequence analysisAdd BLAST16
Compositional biasi3532 – 3562PolarSequence analysisAdd BLAST31
Compositional biasi3595 – 3638PolarSequence analysisAdd BLAST44

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1179 – 1227CXXC-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

BromodomainPROSITE-ProRule annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160099

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15693, ePHD_KMT2A, 1 hit
cd15588, PHD1_KMT2A, 1 hit
cd15590, PHD2_KMT2A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR037927, KMT2A
IPR041958, KMT2A_ePHD
IPR042023, KMT2A_PHD1
IPR042025, KMT2A_PHD2
IPR016569, MeTrfase_trithorax
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR002857, Znf_CXXC
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR45838:SF2, PTHR45838:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 2 hits
PF00856, SET, 1 hit
PF02008, zf-CXXC, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010354, Methyltransferase_trithorax, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297, BROMO, 1 hit
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS51058, ZF_CXXC, 1 hit
PS50016, ZF_PHD_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F7FZ49-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHSCRWRFP ARPGTTGGGG GGGRRGLGGA PRQRVPALLL PPGPPVGGGG
60 70 80 90 100
PGAPPSPPAV AAAAAAAGSS GAGVPGGAAA ASAASSSSAS SSSSSSSSAS
110 120 130 140 150
SGPALLRVGP GFDAALQVSA AIGTNLRRFR AVFGESGGGG GSGELTTQIP
160 170 180 190 200
CSWRTKGHIH DKKTEPFRLL AWSWCLNDEQ FLGFGSDEEV RVRSPTRSPS
210 220 230 240 250
VKTSPRKPRG RPRSGSDRNS AILSDPSVFS PLNKSETKSG DKIKKKDSKS
260 270 280 290 300
IEKKRGRPPT FPGVKIKITH GKDISELPKG NKEDNLKKIK RTPSATFQQA
310 320 330 340 350
TKIKKLRAGK LSPLKSKFKT GKLQIGRKGV QIVRRRGRPP STERIKTPSG
360 370 380 390 400
LLINSELEKP QKVRKDKEGT PPLTKEDKTV VRQSPRRIKP VRIIPSSKRT
410 420 430 440 450
DATIAKQLLQ RAKKGAQKKI EKEAAQLQGR KVKTQVKNIR QFIMPVVSAI
460 470 480 490 500
SSRIIKTPRR FIEDEDYDPP IKIARLESTP NSRFSAPSCG SSEKSSAASQ
510 520 530 540 550
HSSQMSSDSS RSSSPSVDTS TDSQASEEIQ VLPEERSDTP EVHTPLPISQ
560 570 580 590 600
SPENESNDRR SRRYSVSERS FGSRTTKKLT LQSAPQQQTS SSPPPPLLTP
610 620 630 640 650
PPPLQPASSI SDHTPWLMPP TIPLASPFLP ASTAPMQGKR KSILREPTFR
660 670 680 690 700
WTSLKHSRSE PQYFSSAKYA KEGLIRKPIF DNFRPPPLTP EDVGFASGFS
710 720 730 740 750
ASGTATSARL FSPLHSGTRF DMHKRSPLLR APRFTPSEAH SRIFESVTLP
760 770 780 790 800
SNRTSAGTSS SGVSNRKRKR KVFSPIRSEP RSPSHSMRTR SGRLSTSELS
810 820 830 840 850
PLTPPSSVSS SLSISVSPLA TSALNPTFTF PSHSLTQSGE SAEKNQRPRK
860 870 880 890 900
QTSAPPEPFS SSSPTPLFPW FTPGSQTERG RNKDKAPEEL SKDRDADKSV
910 920 930 940 950
EKDKSRERDR EREKENKRES RKEKRKKGSE IQSSSALYPV GRVSKEKVVG
960 970 980 990 1000
EDVATSSSAK KATGRKKSSS HDSGTDITSV TLGDTTAVKT KILIKKGRGN
1010 1020 1030 1040 1050
LEKTNLDLGP TAPSLEKEKT LCLSTPSSST VKHSTSSIGS MLAQADKLPM
1060 1070 1080 1090 1100
TDKRVASLLK KAKAQLCKIE KSKSLKQTDQ PKAQGQESDS SETSVRGPRI
1110 1120 1130 1140 1150
KHVCRRAAVA LGRKRAVFPD DMPTLSALPW EEREKILSSM GNDDKSSIAG
1160 1170 1180 1190 1200
SEDAEPLAPP IKPIKPVTRN KAPQEPPVKK GRRSRRCGQC PGCQVPEDCG
1210 1220 1230 1240 1250
VCTNCLDKPK FGGRNIKKQC CKMRKCQNLQ WMPSKAYLQK QAKAVKKKEK
1260 1270 1280 1290 1300
KSKTSEKKES KESSVVKNVV DSSQKPTPSA REDPAPKKSS SEPPPRKPVE
1310 1320 1330 1340 1350
EKSEEGNVSA PGPESKQATI PASRKSSKQV SQPAPVIPPQ PPTTGPPRKE
1360 1370 1380 1390 1400
VPKTTPSEPK KKQPPPPESG PEQSKQKKVA PRPSIPVKQK PKEKEKPPPV
1410 1420 1430 1440 1450
NKQENAGTLN ILSTLSNGNS SKQKIPADGV HRIRVDFKED CEAENVWEMG
1460 1470 1480 1490 1500
GLGILTSVPI TPRVVCFLCA SSGHVEFVYC QVCCEPFHKF CLEENERPLE
1510 1520 1530 1540 1550
DQLENWCCRR CKFCHVCGRQ HQATKQLLEC NKCRNSYHPE CLGPNYPTKP
1560 1570 1580 1590 1600
TKKKKVWICT KCVRCKSCGS TTPGKGWDAQ WSHDFSLCHD CAKLFAKGNF
1610 1620 1630 1640 1650
CPLCDKCYDD DDYESKMMQC GKCDRWVHSK CENLSDEMYE ILSNLPESVA
1660 1670 1680 1690 1700
YTCVNCTERH PAEWRLALEK ELQISLKQVL TALLNSRTTS HLLRYRQAAK
1710 1720 1730 1740 1750
PPDLNPETEE SIPSRSSPEG PDPPVLTEVS KQDDQQPLDL EGVKRKMDQG
1760 1770 1780 1790 1800
NYTSVLEFSD DIVKIIQAAI NSDGGQPEIK KANSMVKSFF IRQMERVFPW
1810 1820 1830 1840 1850
FSVKKSRFWE PNKVSSNSGM LPNAVLPPSL DHNYAQWQER EENSHTEQPP
1860 1870 1880 1890 1900
LMKKIIPAPK PKGPGEPDSP TPLHPPTPPI LSTDRSREDS PELNPPPGIE
1910 1920 1930 1940 1950
DNRQCALCLT YGDDSANDAG RLLYIGQNEW THVNCALWSA EVFEDDDGSL
1960 1970 1980 1990 2000
KNVHMAVIRG KQLRCEFCQK PGATVGCCLT SCTSNYHFMC SRAKNCVFLD
2010 2020 2030 2040 2050
DKKVYCQRHR DLIKGEVVPE NGFEVFRRVF VDFEGISLRR KFLNGLEPEN
2060 2070 2080 2090 2100
IHMMIGSMTI DCLGILNDLS DCEDKLFPIG YQCSRVYWST TDARKRCVYT
2110 2120 2130 2140 2150
CKIVECRPPV VEPDINSTVE HDENRTIAHS PTSFTESSSK ENQNTAEIIS
2160 2170 2180 2190 2200
PPSPDRPPHS QTSGSCYYHV ISKVPRIRTP SYSPTQRSPG CRPLPSAGSP
2210 2220 2230 2240 2250
TPTTHEIVTV GDPLLSSGLR SIGSRRHSTS SLSPQRSKLR IMSPMRTGNT
2260 2270 2280 2290 2300
YSRNNVSSVS TIGTATDLES SAKAVDHVLG PLNSSTSLGQ NTSTSSNLQR
2310 2320 2330 2340 2350
TVVTVGNKNS HLDGSSSSEM KQSSASDLAS KSSSLKGEKT KVLSSKSSEG
2360 2370 2380 2390 2400
SAHNVAYPGI PKLTPQVHNT TSRELNVSKI GSFAEPSSVS FSSKEALSFP
2410 2420 2430 2440 2450
HLHLRGQRND RDQHTDSTQS ANPSPDEDTE VKTLKLSGMS NRSSIINEHM
2460 2470 2480 2490 2500
GSSSRDRRQK GKKSCKETFK EKHSSKSFLE PGQVTTGEEG NLKPEFMDEV
2510 2520 2530 2540 2550
LTPEYMGQRP CNNVSSDKIG DKGLSMPGVP KAPPMQVEGS AKELQAPRKR
2560 2570 2580 2590 2600
TVKVTLTPLK MENESQSKNT LKESSPASPL QIESTSPPEP ISASENPADG
2610 2620 2630 2640 2650
PVAQPSPNNT SCQDSQSNNY QNLPVQDRNL MLPDGPKPQE DGSFKRRYPR
2660 2670 2680 2690 2700
RSARARSNMF FGLTPLYGVR SYGEEDIPFY SSSTGKKRGK RSAEGQVDGA
2710 2720 2730 2740 2750
DDLSTSDEDD LYYYNFTRTV ISSGGEERLA SHNLFREEEQ CDLPKISQLD
2760 2770 2780 2790 2800
GVDDGTESDT SVTATTRKSS QIPKRNGKEN GTENLKIDRP EDAGEKEHVI
2810 2820 2830 2840 2850
KSSVGHKNEP KMDNCHSVSR VKTQGQDSLE AQLSSLESSR RVHTSTPSDK
2860 2870 2880 2890 2900
NLLDTYNTEL LKSDSDNNNS DDCGNILPSD IMDFVLKNTP SMQALGESPE
2910 2920 2930 2940 2950
SSSSELLNLG EGLGLDSNRE KDMGLFEVFS QQLPTTEPVD SSVSSSISAE
2960 2970 2980 2990 3000
EQFELPLELP SDLSVLTTRS PTVPSQNPSR LAVISDSGEK RVTITEKSVA
3010 3020 3030 3040 3050
SSEGDPALLS PGVDPTPEGH MTPDHFIQGH MDADHISSPP CGSVEQGHGN
3060 3070 3080 3090 3100
NQDLTRNSST PGLQVPVSPT VPIQNQKYVP NSTDSPGPSQ ISNAAVQTTP
3110 3120 3130 3140 3150
PHLKPATEKL IVVNQNMQPL YVLQTLPNGV TQKIQLTSSV SSTPSVMETN
3160 3170 3180 3190 3200
TSVLGPMGSG LTLTTGLNPS LPTSQSLFPS ASKGLLPMSH HQHLHSFPAA
3210 3220 3230 3240 3250
TQSSFPPNIS SPPSGLLIGV QPPPDPQLLV SESSQRTDLS TTVATPSSGL
3260 3270 3280 3290 3300
KKRPISRLQT RKNKKLAPSS TPSNIAPSDV VSNMTLINFT PSQLPNHPNL
3310 3320 3330 3340 3350
LDLGSLNTSS HRTVPNIIKR SKSSIMYFEP APLLPQSVGG TAATASGTST
3360 3370 3380 3390 3400
ISQDTSHLTS GSVSGLASSS SVLNVVSMQT TTTPTSSAPV PGHVTLTNPR
3410 3420 3430 3440 3450
LLGTPDIGSI SNLLIKASQQ SLGIQDQPVA LPPSSGMFPQ LGTSQTPSTA
3460 3470 3480 3490 3500
AMTAASSICV LPSTQTTGVT AASPSGEADE HYQLQHVNQL LASKTGIHSS
3510 3520 3530 3540 3550
QRDLDSASGP QVSNFTQTVD APNSVGLEQN KALSSAVQAS STSPGGSPSS
3560 3570 3580 3590 3600
PSSGQRSASP SVPGPTKPKP KTKRFQLPLD KGNGKKHKVS HLRTSSSEAH
3610 3620 3630 3640 3650
IPDQEATSLT SGTGTPGAEA EQQDTANVEQ SSQKECGQPA GQVAVLPEVQ
3660 3670 3680 3690 3700
VTQNPANEQE STEPKTVEEE ESNFSSPLML WLQQEQKRKE SITEKKPKKG
3710 3720 3730 3740 3750
LVFEISSDDG FQICAESIED AWKSLTDKVQ EARSNARLKQ LSFAGVNGLR
3760 3770 3780 3790 3800
MLGILHDAVV FLIEQLSGAK HCRNYKFRFH KPEEANEPPL NPHGSARAEV
3810 3820 3830 3840 3850
HLRKSAFDMF NFLASKHRQP PEYNPNDEEE EEVQLKSARR ATSMDLPMPM
3860 3870 3880 3890 3900
RFRHLKKTSK EAVGVYRSPI HGRGLFCKRN IDAGEMVIEY AGNVIRSIQT
3910 3920 3930 3940 3950
DKREKYYDSK GIGCYMFRID DSEVVDATMH GNAARFINHS CEPNCYSRVI
3960 3970 3980 3990 4000
NIDGQKHIVI FAMRKIYRGE ELTYDYKFPI EDASNKLPCN CGAKKCRKFL

N
Length:4,001
Mass (Da):435,828
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6B64EC32662BBC6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7FZ57F7FZ57_MACMU
Histone-lysine N-methyltransferase
KMT2A
3,968Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMMUT00000007723; ENSMMUP00000007253; ENSMMUG00000005482
ENSMMUT00000093358; ENSMMUP00000063627; ENSMMUG00000005482

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSMMUT00000007723; ENSMMUP00000007253; ENSMMUG00000005482
ENSMMUT00000093358; ENSMMUP00000063627; ENSMMUG00000005482

Phylogenomic databases

GeneTreeiENSGT00940000160099

Gene expression databases

BgeeiENSMMUG00000005482, Expressed in brain and 23 other tissues

Family and domain databases

CDDicd15693, ePHD_KMT2A, 1 hit
cd15588, PHD1_KMT2A, 1 hit
cd15590, PHD2_KMT2A, 1 hit
Gene3Di3.30.40.10, 3 hits
InterProiView protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR037927, KMT2A
IPR041958, KMT2A_ePHD
IPR042023, KMT2A_PHD1
IPR042025, KMT2A_PHD2
IPR016569, MeTrfase_trithorax
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR002857, Znf_CXXC
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR45838:SF2, PTHR45838:SF2, 1 hit
PfamiView protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 2 hits
PF00856, SET, 1 hit
PF02008, zf-CXXC, 1 hit
PIRSFiPIRSF010354, Methyltransferase_trithorax, 2 hits
SMARTiView protein in SMART
SM00297, BROMO, 1 hit
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS51058, ZF_CXXC, 1 hit
PS50016, ZF_PHD_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7FZ49_MACMU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7FZ49
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: October 7, 2020
This is version 55 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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