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Entry version 53 (12 Aug 2020)
Sequence version 2 (11 Dec 2019)
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Protein
Submitted name:

AT-hook containing transcription factor 1

Gene

AHCTF1

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AT-hook containing transcription factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AHCTF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca mulatta (Rhesus macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9544 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006718 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:69690, AHCTF1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

    NucleusARBA annotation

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMMUG00000016408, Expressed in spermatocyte and 21 other tissues

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    9544.ENSMMUP00000021553

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 489ELYS-bbInterPro annotationAdd BLAST489
    Domaini687 – 909ELYSInterPro annotationAdd BLAST223

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1267 – 1295DisorderedSequence analysisAdd BLAST29
    Regioni1717 – 1799DisorderedSequence analysisAdd BLAST83
    Regioni1877 – 2092DisorderedSequence analysisAdd BLAST216
    Regioni2116 – 2230DisorderedSequence analysisAdd BLAST115

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1267 – 1286PolarSequence analysisAdd BLAST20
    Compositional biasi1747 – 1772PolarSequence analysisAdd BLAST26
    Compositional biasi1881 – 1913PolyampholyteSequence analysisAdd BLAST33
    Compositional biasi1914 – 1928PolarSequence analysisAdd BLAST15
    Compositional biasi1933 – 1978PolyampholyteSequence analysisAdd BLAST46
    Compositional biasi2028 – 2050PolyampholyteSequence analysisAdd BLAST23
    Compositional biasi2051 – 2068PolarSequence analysisAdd BLAST18
    Compositional biasi2129 – 2154PolyampholyteSequence analysisAdd BLAST26
    Compositional biasi2194 – 2211PolyampholyteSequence analysisAdd BLAST18
    Compositional biasi2215 – 2230BasicSequence analysisAdd BLAST16

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG502QU0D, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000018900

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_001145_0_0_1

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR032040, ELYS-bb
    IPR025151, ELYS_dom
    IPR011047, Quinoprotein_ADH-like_supfam

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF13934, ELYS, 1 hit
    PF16687, ELYS-bb, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF50998, SSF50998, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

    F7FYF6-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MRDLRAQVTS GLLPFPEVTL QALGEDEITL ESVLRGKFAA GKNGLACLAC
    60 70 80 90 100
    GPQLEVVNSV TGERLSAYRF SGVNEQPPVV LAVKEFSWQK RTGLLIGLEE
    110 120 130 140 150
    TEGSVLCLYD LGISKVVKAV VLPGRVTAIE PIINHGGASA STQHLHPSLR
    160 170 180 190 200
    WLFGVAAVVT DVGQILLIDL CLDDLSCNQN EVEASDLEVL TGIPAEVPHI
    210 220 230 240 250
    RESVMREGRH LCFQLVSPTG TAVSTLSYIN RTNQLAVGFS DGYLALWNMK
    260 270 280 290 300
    SMKREYYIQL ESGRVPVYAV TFQEPENDPR NCCYLWAVQS TQDSEGDVLS
    310 320 330 340 350
    LHLLQLAFGN RKCLASGQIL YEGLEYCEER YTLDLTGGMF PLRGQTSNTK
    360 370 380 390 400
    LLGCQSIEKF RSHGDREEGM NEALSPDTSV SVFTWQVNIY GQGKPSIYLG
    410 420 430 440 450
    LFDINRWYHA QMPDSLRSGE YLHNCSYFAL WSLESVVSRT SPHGILDILV
    460 470 480 490 500
    HERSLNRGVP PSYPPPEQFF NPSTYNFDAT CLLNSGVVHL TCTGFQKETL
    510 520 530 540 550
    TFLKKSGPSL NEVIPDGYNR CLVAGLLSPR FVDIQPSSLS QEEQLEAILS
    560 570 580 590 600
    AAIQTSSLGL LTGYIKRWIT EEQPNSATNL RFVLEWTWNK VVLTKEEFDR
    610 620 630 640 650
    LCVPLFDGSC HFMDPQTIQS IQQCYLLLSN LNIVLSCFAS EAREITERDD
    660 670 680 690 700
    SVQLSRLCYN YPVIQNYYTS RRQKFERLSR GKWNPDCLMI DGLVSQLGER
    710 720 730 740 750
    IEKLWKRDEG GTGKYPPASL HAVLDMYLLD GVTEAAKHSI TIYLLLDIMY
    760 770 780 790 800
    SFPNKTDTPI ESFPTVFAIS WGQVKLIQGL WLIDHNDFES GLDLLFHPAT
    810 820 830 840 850
    AKPLSWQHSK IIQAFMSQGE HRQALRYIQT MKPTVSSGSD VILHLTVLLF
    860 870 880 890 900
    NRCMVEAWSF LRQHCNRLNI EELLKHMYEV CQEMGLMEDL LKLPFTDTEQ
    910 920 930 940 950
    ECLVNFLQSS ASVQNHEFLL VHHLQRANYV PALKLNQTLK INVMNDRDPR
    960 970 980 990 1000
    LRERSLARNS ILDQYGKILP RVHRKLAVER AKPYHLSTSS VFRLVSRPKP
    1010 1020 1030 1040 1050
    LSAVPKQVVT GTVLTRSVFI NNVLSKIGEV WASKEPISST TPYNSSKIEE
    1060 1070 1080 1090 1100
    PSPIVYSLPA PELPEAFFGT PISKASQKIS RLLDLVVQPV PQPSQCSEFI
    1110 1120 1130 1140 1150
    QQCSVKSPLY LVSRSLSSSS QLKGSPQAVS RTSELHLLET PLVVKKAKSL
    1160 1170 1180 1190 1200
    AMSVTTSGFS EFTPQSILRS ALRSTPLASP SPSPGRSPQR LKETRISFVE
    1210 1220 1230 1240 1250
    EDVNSKWIPG AADDSKLEVF TTPKKCTVPA ETEWLKSKDR TTSFFLNSPE
    1260 1270 1280 1290 1300
    KEHQEMDVGS QSLEKLDVSK GNSSVSITSD ETTLEYQDAP SPEDLEETVF
    1310 1320 1330 1340 1350
    RVCKPKSSST ALTTNVTEQT EKDGDKDAFA SEVTPSDLQK QMGHLEDAET
    1360 1370 1380 1390 1400
    KDLLVAAEAF SELNHLSPVQ GIEASLCAPS VYEGKMFTQK SKLPVLDEGL
    1410 1420 1430 1440 1450
    TSVETYTSAI RANDNKSVAG ILGDSGNSSL TVSEGPIISE RRLNQEVVLN
    1460 1470 1480 1490 1500
    LKEDDEVEVD VLKESVNLPE EKLPISDSPP DTQEIHVIEQ EKLEAQDSGE
    1510 1520 1530 1540 1550
    EARNLSFNEL YPSGTLKLQY NFDTIDQQFC DLADNKDTAE CDIAEVDGEL
    1560 1570 1580 1590 1600
    FVAQSNFTLI LEGEEGEVEP GDFASSDVLP KAANTATEEK LVCSGENDNH
    1610 1620 1630 1640 1650
    GQVADLPSAI TSDQKSQKVE TLPYVPEPIK VAIAENLLDV IKDTRSKEIT
    1660 1670 1680 1690 1700
    SDTMEQSIHE TIPLVSQNIM CPTKLVKSAC KTAQETSTVT LNVSQVDVVS
    1710 1720 1730 1740 1750
    SKTHTRGQRI QNVNVKSTQQ EAAADVATPK MPGQSVRKKT RKPQEISEAS
    1760 1770 1780 1790 1800
    ENTYSDVKGI SENQQISQNP ITPRRGRRKK EVNQDILENT SSVEQELQIT
    1810 1820 1830 1840 1850
    TGRESKRLKS SQLLEPAVEE TIKKEVTVSS VTKRTPRRIK RSVESQESVE
    1860 1870 1880 1890 1900
    IINDLKVSNV TSPSRMIRKL RSANLDASEN IGNKPDDKSS DEQLPIKRIR
    1910 1920 1930 1940 1950
    RVRGREVSPS DVREDSNLDS SQLSLQAELD MSAIPRKRGR PRKIHPSEDV
    1960 1970 1980 1990 2000
    GSKAVKEEGS PKKKEAPSIK RRSTRSTAAK SENTDVGKPA SGKSILVPNK
    2010 2020 2030 2040 2050
    ELSMVMSSKK KLTKKTENQS QKGSLQSVSE ERTDEMTHKE TNDREERLLA
    2060 2070 2080 2090 2100
    TASFTKSSRS TRTRSSKAIL LPDLSEPNSE PLFSPVSEVP RKAKAKKIEV
    2110 2120 2130 2140 2150
    PAQLKELVSD LSSQFVISPP TLRSRQKNTS NKNKLEDELK DDAQSVETVG
    2160 2170 2180 2190 2200
    KPKAKRIRTS KTKQASKNTE KESAWSPPPI EIRLISPLAS PVDRVKSKPR
    2210 2220 2230
    KTTEVTGTGR GRSRKKLSSY PKQILRRKML
    Length:2,230
    Mass (Da):248,154
    Last modified:December 11, 2019 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i380516FFD13506C2
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A5F7Z9E3A0A5F7Z9E3_MACMU
    AT-hook containing transcription fa...
    AHCTF1
    2,336Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A5F8A9P9A0A5F8A9P9_MACMU
    AT-hook containing transcription fa...
    AHCTF1
    2,229Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A5F8AR97A0A5F8AR97_MACMU
    AT-hook containing transcription fa...
    AHCTF1
    2,222Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMMUT00000023043; ENSMMUP00000021554; ENSMMUG00000016408

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    STRINGi9544.ENSMMUP00000021553

    Genome annotation databases

    EnsembliENSMMUT00000023043; ENSMMUP00000021554; ENSMMUG00000016408

    Organism-specific databases

    VGNCiVGNC:69690, AHCTF1

    Phylogenomic databases

    eggNOGiENOG502QU0D, Eukaryota
    GeneTreeiENSGT00390000018900
    HOGENOMiCLU_001145_0_0_1

    Gene expression databases

    BgeeiENSMMUG00000016408, Expressed in spermatocyte and 21 other tissues

    Family and domain databases

    InterProiView protein in InterPro
    IPR032040, ELYS-bb
    IPR025151, ELYS_dom
    IPR011047, Quinoprotein_ADH-like_supfam
    PfamiView protein in Pfam
    PF13934, ELYS, 1 hit
    PF16687, ELYS-bb, 1 hit
    SUPFAMiSSF50998, SSF50998, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7FYF6_MACMU
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7FYF6
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: December 11, 2019
    Last modified: August 12, 2020
    This is version 53 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteomeImported
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

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