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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

CACNA1F

Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:CACNA1FImported
OrganismiOrnithorhynchus anatinus (Duckbill platypus)Imported
Taxonomic identifieri9258 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataOrnithorhynchidaeOrnithorhynchus
Proteomesi
  • UP000002279 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei94 – 113HelicalSequence analysisAdd BLAST20
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Transmembranei157 – 175HelicalSequence analysisAdd BLAST19
Transmembranei229 – 252HelicalSequence analysisAdd BLAST24
Transmembranei308 – 329HelicalSequence analysisAdd BLAST22
Transmembranei341 – 363HelicalSequence analysisAdd BLAST23
Transmembranei511 – 530HelicalSequence analysisAdd BLAST20
Transmembranei542 – 560HelicalSequence analysisAdd BLAST19
Transmembranei673 – 690HelicalSequence analysisAdd BLAST18
Transmembranei710 – 732HelicalSequence analysisAdd BLAST23
Transmembranei930 – 956HelicalSequence analysisAdd BLAST27
Transmembranei976 – 1005HelicalSequence analysisAdd BLAST30
Transmembranei1165 – 1186HelicalSequence analysisAdd BLAST22
Transmembranei1192 – 1213HelicalSequence analysisAdd BLAST22
Transmembranei1300 – 1318HelicalSequence analysisAdd BLAST19
Transmembranei1391 – 1415HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSOANG00000013580 Expressed in 3 organ(s), highest expression level in brain

Interactioni

Protein-protein interaction databases

STRINGi9258.ENSOANP00000021420

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1549 – 1583Ca_chan_IQInterPro annotationAdd BLAST35

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
GeneTreeiENSGT00830000128247
InParanoidiF7FW49
OMAiLNQTECR
OrthoDBiEOG091G0TKO
TreeFamiTF312805

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR031688 CAC1F_C
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR030157 VDCC_L_a1F
IPR005446 VDCC_L_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF184 PTHR10037:SF184, 1 hit
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16885 CAC1F_C, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 5 hits
PRINTSiPR00167 CACHANNEL
PR01630 LVDCCALPHA1
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit

Sequencei

Sequence statusi: Complete.

F7FW49-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGSQNGKAL QPHPHPSRPK LSPGPEWGLS LEPRAGGPDH PGSDTPRRRL
60 70 80 90 100
QHGKHKSQGA GGTQRSPRAL FCLSLNNPLR RSCISIVEWK PFDVLILVTI
110 120 130 140 150
FANCVALGVY IPFPENPNLE QVEYVFLIIF TAETCLKIVA YGLVLHPSAY
160 170 180 190 200
IRNGWNLLDF VIVVVGLFSV LLEQAPNRSR DAHHPSGKPG GFDVKALRAF
210 220 230 240 250
RVLRPLRLVS GVPSLHIVLN SIMKAMVPLL HIALLVLFVI IIYAIIGLEL
260 270 280 290 300
FIGRMHKTCF YVGSELEAEE DPSPCAFSGH GRQCTTNNTE CRGRWAGPNG
310 320 330 340 350
GITNFDNFFF AMLTVFQCIT MEGWTDVLYW MQDAMGHELP WLYFVSLVIF
360 370 380 390 400
GSFFVLNLVL GVLSGEFSKE REKAKARGDF QKLREKQQME EDLRGYLDWI
410 420 430 440 450
TQAEDLEPDD GQGEEEMAKE RRHHRVTLAD LTDKKRSRLH WFSHSTRSAS
460 470 480 490 500
SHASLPASET ASVTTENTGE EEATGCCATC IVKIAKTKVC RWLRRSNRLL
510 520 530 540 550
RRKCRLAVKS ASFYWMVLLL VFLNTLTIAS EHHNQPPWLT QIQAYANKVL
560 570 580 590 600
LSLFTLEMLL KLYSLGPQAY GVSFFNRFDC FVVCGGILET ALVELDIMQP
610 620 630 640 650
LGISVLRCVR LLRIFKVTRS EPGGGEGLGC CGGLWGQGAG RPESWEVEGL
660 670 680 690 700
GDCPIPIERK GGAVNRWAKR KRMSSLSPFP SFFLPASHIL TGEDWNSVMY
710 720 730 740 750
DGIMAYGGPF FPGMLVCVYF IILFICGNYI LLNVFLAIAV DNLAGGDNIN
760 770 780 790 800
TSKGQDNPDY LGPPTPPLPH HPQGQEENGG EERGRGADAG SWRFGDEGGE
810 820 830 840 850
EEDSEAESLA ESQLEKLQEV VPKEKVVPIP EGSSFFCLSQ TNPWKPLCHV
860 870 880 890 900
TRHPTHHFFV GLSQAFRTVH CIRWEYCLHS PWLRPLLSLP CLAFPTPLYS
910 920 930 940 950
SQFLRVELQQ MTAFGAFLHK GSFCRNWFNL LDLLVVSVSL ISFGIHSSAI
960 970 980 990 1000
SVVKILRVLR VLRPLRAINR AKGLKHVVQC VFVAIRTIGN IMIVTTLLQF
1010 1020 1030 1040 1050
MFACIGVQLF KGKFYSCTDE AKHNPGECKG TFIVYQDGDV NHPMVRERVW
1060 1070 1080 1090 1100
HNSDFNFDNV LAGMMALFTV STFEGWPELT ERGTEGKKGP GGVLSRADEG
1110 1120 1130 1140 1150
SRRGPPRPHL RIHHRAQGEQ EYKNCELDKN QRQCVEYALK AQPLRRYIPK
1160 1170 1180 1190 1200
NPTQHRVWAA VNSTAFEYIM FVLILLNTIA LAMQHYEQTA PFNYAMDILN
1210 1220 1230 1240 1250
MVFTGLFTAE MLLKIIAFKP KHYFCDAWNT FDALIVVGSL VDIAVTEVNN
1260 1270 1280 1290 1300
GGHLGESSED SSRISITFFR LFRVMRLVKL LSKGEGIRTL LWTFIKSFQA
1310 1320 1330 1340 1350
LPYVALLIAM IFFIYAVIGM QTFGKVAMQD GTQINRNNNF QTFPQAVLLL
1360 1370 1380 1390 1400
FRCATGEAWQ EIMLASLPGK RCDPESDYGP GEEFTCGSNF AIVYFISFFM
1410 1420 1430 1440 1450
LCAFLIINLF VAVIMDNFDY LTRDWSILGP HHLDEFKRIW SEYDPAAKGR
1460 1470 1480 1490 1500
IKHLDVVALL RRIQPPLGFG KLCPHRVACK RLVAMNMPLD ADGTVTFNAT
1510 1520 1530 1540 1550
LFALVRTSLR IKTEGNLDLA NQELRIVIKK IWKRTKPRLL DEVIPTPEEE
1560 1570 1580 1590 1600
EVTVGKFYAT FLIQDYFRKF RRRKERGLLG SEASPSRSSA LQAGLKSLQD
1610 1620 1630 1640 1650
LAPEMRQALS CDLKGGETEG QKAESRLAPD NPRPPSRWTS ATSLPLNTGD
1660 1670 1680 1690 1700
SEPSTGGPPG SLSSPAASQP RGPRGPGEEE EEEEGSPSPG QPMESRLGPH
1710 1720 1730 1740 1750
SLRGQEGREE EWSGGGFTRA QTGAETRPGG PCFLPRPFRH FSQSRAAGRL
1760 1770 1780 1790 1800
DGHRAQRRRL LPPTPAGRKP SFTIQCLRRQ GSCEDMPIPG TYHQNPPPGR
1810 1820 1830 1840 1850
RRPQNSWANP VPRGRLLYAP LILVEEARGN GWYQEEPEGP YRAYTQLRVP
1860 1870 1880 1890 1900
TQRPSGSRGK RGSADSLVEA VSLGRPRWKQ GPEGVALPKG KIANPVQLEN
1910
EEMENAANDL L
Length:1,911
Mass (Da):213,827
Last modified:July 27, 2011 - v1
Checksum:i96A51508A71F3C7D
GO

Genome annotation databases

EnsembliENSOANT00000021423; ENSOANP00000021420; ENSOANG00000013580

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9258.ENSOANP00000021420

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOANT00000021423; ENSOANP00000021420; ENSOANG00000013580

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
GeneTreeiENSGT00830000128247
InParanoidiF7FW49
OMAiLNQTECR
OrthoDBiEOG091G0TKO
TreeFamiTF312805

Gene expression databases

BgeeiENSOANG00000013580 Expressed in 3 organ(s), highest expression level in brain

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR031688 CAC1F_C
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR030157 VDCC_L_a1F
IPR005446 VDCC_L_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF184 PTHR10037:SF184, 1 hit
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16885 CAC1F_C, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 5 hits
PRINTSiPR00167 CACHANNEL
PR01630 LVDCCALPHA1
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF7FW49_ORNAN
AccessioniPrimary (citable) accession number: F7FW49
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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