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Entry version 65 (07 Apr 2021)
Sequence version 2 (22 Jul 2015)
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Protein
Submitted name:

Baculoviral IAP repeat-containing 3

Gene

Birc3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-168638, NOD1/2 Signaling Pathway
R-RNO-5357905, Regulation of TNFR1 signaling
R-RNO-5357956, TNFR1-induced NFkappaB signaling pathway
R-RNO-5668541, TNFR2 non-canonical NF-kB pathway
R-RNO-5675482, Regulation of necroptotic cell death
R-RNO-5676594, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
R-RNO-5689880, Ub-specific processing proteases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Baculoviral IAP repeat-containing 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Birc3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
621282, Birc3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F7FLN8

PRoteomics IDEntifications database

More...
PRIDEi
F7FLN8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000005731, Expressed in spleen and 21 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F7FLN8, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000007702

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F7FLN8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini474 – 563CARDInterPro annotationAdd BLAST90
Domaini591 – 626RING-typeInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili455 – 475Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IAP family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1101, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154175

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7FLN8

Identification of Orthologs from Complete Genome Data

More...
OMAi
SPIIHFG

Database of Orthologous Groups

More...
OrthoDBi
1340284at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00022, BIR, 3 hits
cd14394, UBA_BIRC2_3, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001370, BIR_rpt
IPR041933, BIRC2/BIRC3_UBA
IPR001315, CARD
IPR011029, DEATH-like_dom_sf
IPR001841, Znf_RING

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00653, BIR, 3 hits
PF00619, CARD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00238, BIR, 3 hits
SM00114, CARD, 1 hit
SM00184, RING, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01282, BIR_REPEAT_1, 3 hits
PS50143, BIR_REPEAT_2, 3 hits
PS50209, CARD, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F7FLN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKQWGISLV VKLTKSHEQN YLPGERLLPS PPCRLTMNMV QGSAFLAKLM
60 70 80 90 100
KSADTFELKY DFSCELYRLS TYSTFPAGVP VSERSLARAG FYYTGVNDKV
110 120 130 140 150
KCFSCGLMLD NWKQGDSPIE KHRKLYPSCS FVQTLNPANS LEASPQPPLP
160 170 180 190 200
STATSTMPSG FAASESTGYF SGSYSSFPSD PVNFRANQDC PAFSTSPYHF
210 220 230 240 250
AMNTEKARLL TYQTWPLSFL SPAELAKAGF YYTGPGDRVA CFACGGKLSN
260 270 280 290 300
WDRKDDPLSE HRRHFPSCPF LKDVGQFTSQ YTVSNLSMQT HAARVRTFST
310 320 330 340 350
WPSSALVHPQ ELASAGFYYT GHSDDVKCFC CDGGLRCWES GDDPWVEHAK
360 370 380 390 400
WFPRCEYLIR IKGQEFVGQV QAGYPHLLEQ LLSTSDSPED ETGEAAIVHL
410 420 430 440 450
GPGENWEDAV MMNTPVVKAA LDMGFSRSLV RQTVQRQILA TGENYRTVSD
460 470 480 490 500
LVIGLLDAED EMREEQTEQE AEEEESDDLT LIRKNKMVLL QHLTPVTPIL
510 520 530 540 550
DCLLSARVIT EQEYDAVKQK PHTLQARTLI DTVLAKGNTA ATSFRNSLQE
560 570 580 590 600
IDPGLYRDIF VRQNIRSLPT DDIAALPMEE QLRKLQEERT CKVCMDREVS
610 620 630
LVFIPCGHLV VCKECAPSLR KCPICRGTIK GTVRTFLS
Length:638
Mass (Da):71,354
Last modified:July 22, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23218B6C40D9EA4A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5XIW4Q5XIW4_RAT
Baculoviral IAP repeat-containing 3
Birc3 rCG_31624
602Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07069023 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_076477.3, NM_023987.3
XP_006242561.1, XM_006242499.3
XP_006242562.1, XM_006242500.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000007702; ENSRNOP00000007702; ENSRNOG00000005731

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
78971

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:78971

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069023 Genomic DNA No translation available.
RefSeqiNP_076477.3, NM_023987.3
XP_006242561.1, XM_006242499.3
XP_006242562.1, XM_006242500.3

3D structure databases

SMRiF7FLN8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007702

Proteomic databases

PaxDbiF7FLN8
PRIDEiF7FLN8

Genome annotation databases

EnsembliENSRNOT00000007702; ENSRNOP00000007702; ENSRNOG00000005731
GeneIDi78971
KEGGirno:78971

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
330
RGDi621282, Birc3

Phylogenomic databases

eggNOGiKOG1101, Eukaryota
GeneTreeiENSGT00940000154175
InParanoidiF7FLN8
OMAiSPIIHFG
OrthoDBi1340284at2759

Enzyme and pathway databases

ReactomeiR-RNO-168638, NOD1/2 Signaling Pathway
R-RNO-5357905, Regulation of TNFR1 signaling
R-RNO-5357956, TNFR1-induced NFkappaB signaling pathway
R-RNO-5668541, TNFR2 non-canonical NF-kB pathway
R-RNO-5675482, Regulation of necroptotic cell death
R-RNO-5676594, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
R-RNO-5689880, Ub-specific processing proteases

Gene expression databases

BgeeiENSRNOG00000005731, Expressed in spleen and 21 other tissues
ExpressionAtlasiF7FLN8, baseline and differential

Family and domain databases

CDDicd00022, BIR, 3 hits
cd14394, UBA_BIRC2_3, 1 hit
InterProiView protein in InterPro
IPR001370, BIR_rpt
IPR041933, BIRC2/BIRC3_UBA
IPR001315, CARD
IPR011029, DEATH-like_dom_sf
IPR001841, Znf_RING
PfamiView protein in Pfam
PF00653, BIR, 3 hits
PF00619, CARD, 1 hit
SMARTiView protein in SMART
SM00238, BIR, 3 hits
SM00114, CARD, 1 hit
SM00184, RING, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS01282, BIR_REPEAT_1, 3 hits
PS50143, BIR_REPEAT_2, 3 hits
PS50209, CARD, 1 hit
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7FLN8_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7FLN8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: July 22, 2015
Last modified: April 7, 2021
This is version 65 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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