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Protein

Interleukin-7

Gene

Il7

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-1266695 Interleukin-7 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-7UniRule annotation
Short name:
IL-7UniRule annotation
Gene namesi
Name:Il7Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2904 Il7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500335865623 – 151Interleukin-7Sequence analysisAdd BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 142UniRule annotation
Disulfide bondi55 ↔ 130UniRule annotation
Disulfide bondi68 ↔ 113UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000011973 Expressed in 9 organ(s), highest expression level in spleen

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000004451
HOVERGENiHBG004609
OMAiNNEPNFF
TreeFamiTF338065

Family and domain databases

Gene3Di1.20.1250.50, 1 hit
InterProiView protein in InterPro
IPR001181 IL-7
IPR018049 IL-7/IL-9_CS
IPR000226 IL-7/IL-9_fam
IPR038325 IL7_sf
PANTHERiPTHR45542 PTHR45542, 1 hit
PfamiView protein in Pfam
PF01415 IL7, 1 hit
PIRSFiPIRSF001942 IL-7, 1 hit
PRINTSiPR00435 INTERLEUKIN7
SMARTiView protein in SMART
SM00127 IL7, 1 hit
PROSITEiView protein in PROSITE
PS00255 INTERLEUKIN_7_9, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

F7FJK6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VSFRYIFGIP PLILVLLPVT SSDCHIKDKD GKAFGSVLMI SINQLDKMTG
60 70 80 90 100
TDSDCPNNEP NFFKKHLCDD TKEAAFLNRA ARKLRQFLKM NISEEFNDHL
110 120 130 140 150
LRVSDGTQTL VNCTSKEEKT IKEQKKNDPC FLKRLLREIK TCWNKILNSS

I
Length:151
Mass (Da):17,309
Last modified:July 22, 2015 - v1
Checksum:iE0BBAD89A2B9D190
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P56478IL7_RAT
Interleukin-7
Il7
154Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07009402 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000016091; ENSRNOP00000016091; ENSRNOG00000011973

Similar proteinsi

Entry informationi

Entry nameiF7FJK6_RAT
AccessioniPrimary (citable) accession number: F7FJK6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: September 12, 2018
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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