Activating transcription factor 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Secalonic acid D alters the expression and phosphorylation of the transcription factors and their binding to cAMP response element in developing murine secondary palate."
    Umesh H., Ganesh B., Reddy C.S.
    J. Craniofac. Genet. Dev. Biol. 20:173-182(2000) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A."
    Rehfuss R.P., Walton K.M., Loriaux M.M., Goodman R.H.
    J. Biol. Chem. 266:18431-18434(1991) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells."
    Takahashi M., Mutoh M., Shoji Y., Kamanaka Y., Naka M., Maruyama T., Sugimura T., Wakabayashi K.
    Oncogene 22:7667-7676(2003) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: RGDInferred from sequence orthologyⁱ
  • "Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays."
    Reinke A.W., Grigoryan G., Keating A.E.
    Biochemistry 49:1985-1997(2010) [PubMed] [Europe PMC] [Abstract]
  • "Molecular basis of coiled-coil oligomerization-state specificity."
    Ciani B., Bjelic S., Honnappa S., Jawhari H., Jaussi R., Payapilly A., Jowitt T., Steinmetz M.O., Kammerer R.A.
    Proc. Natl. Acad. Sci. U.S.A. 107:19850-19855(2010) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGDInferred from direct assayⁱ
  • "CREB-AP1 protein complexes regulate transcription of the collagen XXIV gene (Col24a1) in osteoblasts."
    Matsuo N., Tanaka S., Gordon M.K., Koch M., Yoshioka H., Ramirez F.
    J. Biol. Chem. 281:5445-5452(2006) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: InterPro
• RNA polymerase II regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A."
    Rehfuss R.P., Walton K.M., Loriaux M.M., Goodman R.H.
    J. Biol. Chem. 266:18431-18434(1991) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGDInferred from direct assayⁱ
  • "Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene."
    Ziel K.A., Campbell C.C., Wilson G.L., Gillespie M.N.
    FASEB J. 18:986-988(2004) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular protein-containing complex assembly Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Transforming growth factor-beta1 down-regulation of major histocompatibility complex class I in thyrocytes: coordinate regulation of two separate elements by thyroid-specific as well as ubiquitous transcription factors."
    Napolitano G., Montani V., Giuliani C., Di Vincenzo S., Bucci I., Todisco V., Laglia G., Coppa A., Singer D.S., Nakazato M., Kohn L.D., Colletta G., Monaco F.
    Mol. Endocrinol. 14:486-505(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA replication Source: RGDInferred from mutant phenotypeⁱ
  • "ATF-1 mediates protease-activated receptor-1 but not receptor tyrosine kinase-induced DNA synthesis in vascular smooth muscle cells."
    Ghosh S.K., Gadiparthi L., Zeng Z.Z., Bhanoori M., Tellez C., Bar-Eli M., Rao G.N.
    J. Biol. Chem. 277:21325-21331(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron projection development Source: RGDInferred from mutant phenotypeⁱ
  • "Dominant negative ATF1 blocks cyclic AMP-induced neurite outgrowth in PC12D cells."
    Shimomura A., Okamoto Y., Hirata Y., Kobayashi M., Kawakami K., Kiuchi K., Wakabayashi T., Hagiwara M.
    J. Neurochem. 70:1029-1034(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from mutant phenotypeⁱ
  • "Myocyte enhancer factor 2B is involved in the inducible expression of NOX1/NADPH oxidase, a vascular superoxide-producing enzyme."
    Katsuyama M., Ozgur Cevik M., Arakawa N., Kakehi T., Nishinaka T., Iwata K., Ibi M., Matsuno K., Yabe-Nishimura C.
    FEBS J. 274:5128-5136(2007) [PubMed] [Europe PMC] [Abstract]
• response to cobalt ion Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin."
    Zaman K., Ryu H., Hall D., O'Donovan K., Lin K.I., Miller M.P., Marquis J.C., Baraban J.M., Semenza G.L., Ratan R.R.
    J. Neurosci. 19:9821-9830(1999) [PubMed] [Europe PMC] [Abstract]
• response to organic cyclic compound Source: RGDInferred from expression patternⁱ
  • "Red wine polyphenols inhibit proliferation of vascular smooth muscle cells and downregulate expression of cyclin A gene."
    Iijima K., Yoshizumi M., Hashimoto M., Kim S., Eto M., Ako J., Liang Y.Q., Sudoh N., Hosoda K., Nakahara K., Toba K., Ouchi Y.
    Circulation 101:805-811(2000) [PubMed] [Europe PMC] [Abstract]

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• identical protein binding Source: RGDInferred from sequence orthologyⁱ
  • "Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays."
    Reinke A.W., Grigoryan G., Keating A.E.
    Biochemistry 49:1985-1997(2010) [PubMed] [Europe PMC] [Abstract]
  • "Molecular basis of coiled-coil oligomerization-state specificity."
    Ciani B., Bjelic S., Honnappa S., Jawhari H., Jaussi R., Payapilly A., Jowitt T., Steinmetz M.O., Kammerer R.A.
    Proc. Natl. Acad. Sci. U.S.A. 107:19850-19855(2010) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: InterPro

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEDSHKSNTS ETASQPGSTV PGIISQIVHQ VSSLSESEES QDSSDSIGSS 
        60         70         80         90        100
QKAHGILARR PSYRKILKDL SSEDTRGRKG DGENPSISAV TSMSVPTPIY 
       110        120        130        140        150
QTSSGQYIAI APNGALQLAS PGPDGVQALQ TLTMTNSSSA QQGAILQYAQ 
       160        170        180        190        200
TSDGQQILVP SNQVVVQTAS GDMQTYQIRT TPSATSLPQT MVMTSPVTLT 
       210        220        230        240        250
SQTTKTDDPQ LKREIRLMKN REAARECRRK KKEYVKCLEN RVAVLENQNK 
       260 
TLIEELKTLK DLYSHKSV                                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ