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UniProtKB - F7FD47 (F7FD47_RAT)
Protein
Submitted name:
Activating transcription factor 1
Gene
Atf1
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
- identical protein binding Source: RGD
- protein-containing complex binding Source: RGD
- protein heterodimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific DNA binding Source: RGD
GO - Biological processi
- cAMP-mediated signaling Source: Ensembl
- positive regulation of DNA replication Source: RGD
- positive regulation of neuron projection development Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- protein-containing complex assembly Source: RGD
- regulation of transcription by RNA polymerase II Source: RGD
- response to cobalt ion Source: RGD
- response to inorganic substance Source: RGD
- response to organic cyclic compound Source: RGD
- response to purine-containing compound Source: Ensembl
Enzyme and pathway databases
Reactomei | R-RNO-199920, CREB phosphorylation |
Names & Taxonomyi
Protein namesi | Submitted name: Activating transcription factor 1Imported |
Gene namesi | Name:Atf1Imported ORF Names:rCG_50522Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1307360, Atf1 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- ATF1-ATF4 transcription factor complex Source: RGD
- ATF4-CREB1 transcription factor complex Source: GO_Central
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
- RNA polymerase II transcription regulator complex Source: RGD
Other locations
- transcription regulator complex Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000061088, Expressed in thymus and 21 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: RGD
- protein heterodimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000052256 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 89 | KIDInterPro annotationAdd BLAST | 60 | |
Domaini | 210 – 261 | BZIPInterPro annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 90 | DisorderedSequence analysisAdd BLAST | 90 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 228 – 262 | Sequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 8 – 51 | Polar residuesSequence analysisAdd BLAST | 44 | |
Compositional biasi | 62 – 81 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG3584, Eukaryota |
GeneTreei | ENSGT00940000158200 |
HOGENOMi | CLU_042675_0_1_1 |
OMAi | THISHIA |
OrthoDBi | 957343at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR029825, ATF1 IPR004827, bZIP IPR046347, bZIP_sf IPR003102, Coactivator_CBP_pKID IPR001630, Leuzip_CREB |
PANTHERi | PTHR45879, PTHR45879, 1 hit PTHR45879:SF2, PTHR45879:SF2, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit PF02173, pKID, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit PS50953, KID, 1 hit |
i Sequence
Sequence statusi: Complete.
F7FD47-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDSHKSNTS ETASQPGSTV PGIISQIVHQ VSSLSESEES QDSSDSIGSS
60 70 80 90 100
QKAHGILARR PSYRKILKDL SSEDTRGRKG DGENPSISAV TSMSVPTPIY
110 120 130 140 150
QTSSGQYIAI APNGALQLAS PGPDGVQALQ TLTMTNSSSA QQGAILQYAQ
160 170 180 190 200
TSDGQQILVP SNQVVVQTAS GDMQTYQIRT TPSATSLPQT MVMTSPVTLT
210 220 230 240 250
SQTTKTDDPQ LKREIRLMKN REAARECRRK KKEYVKCLEN RVAVLENQNK
260
TLIEELKTLK DLYSHKSV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH474035 Genomic DNA Translation: EDL86959.1 |
RefSeqi | NP_001094365.1, NM_001100895.1 |
Genome annotation databases
Ensembli | ENSRNOT00000087298.2; ENSRNOP00000073278.1; ENSRNOG00000061088.2 |
GeneIDi | 315305 |
KEGGi | rno:315305 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH474035 Genomic DNA Translation: EDL86959.1 |
RefSeqi | NP_001094365.1, NM_001100895.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000052256 |
Genome annotation databases
Ensembli | ENSRNOT00000087298.2; ENSRNOP00000073278.1; ENSRNOG00000061088.2 |
GeneIDi | 315305 |
KEGGi | rno:315305 |
Organism-specific databases
CTDi | 466 |
RGDi | 1307360, Atf1 |
Phylogenomic databases
eggNOGi | KOG3584, Eukaryota |
GeneTreei | ENSGT00940000158200 |
HOGENOMi | CLU_042675_0_1_1 |
OMAi | THISHIA |
OrthoDBi | 957343at2759 |
Enzyme and pathway databases
Reactomei | R-RNO-199920, CREB phosphorylation |
Gene expression databases
Bgeei | ENSRNOG00000061088, Expressed in thymus and 21 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR029825, ATF1 IPR004827, bZIP IPR046347, bZIP_sf IPR003102, Coactivator_CBP_pKID IPR001630, Leuzip_CREB |
PANTHERi | PTHR45879, PTHR45879, 1 hit PTHR45879:SF2, PTHR45879:SF2, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit PF02173, pKID, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit PS50953, KID, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F7FD47_RAT | |
Accessioni | F7FD47Primary (citable) accession number: F7FD47 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2013 |
Last sequence update: | April 3, 2013 | |
Last modified: | May 25, 2022 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |