UniProtKB - F7FCE6 (F7FCE6_MACMU)
Protein
Phosphatidylinositol N-acetylglucosaminyltransferase
Gene
PIGC
Organism
Macaca mulatta (Rhesus macaque)
Status
Functioni
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-α-D-glucosamine = a 6-(N-acetyl-α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H+ + UDPARBA annotationEC:2.4.1.198ARBA annotation
: glycosylphosphatidylinositol-anchor biosynthesis Pathwayi
This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.ARBA annotationView all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.
GO - Molecular functioni
- phosphatidylinositol N-acetylglucosaminyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- GPI anchor biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | GlycosyltransferaseImportedARBA annotation, Transferase |
Biological process | GPI-anchor biosynthesisARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00196 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositol N-acetylglucosaminyltransferaseARBA annotation (EC:2.4.1.198ARBA annotation) |
Gene namesi | Name:PIGCImported |
Organismi | Macaca mulatta (Rhesus macaque)Imported |
Taxonomic identifieri | 9544 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:75986, PIGC |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endoplasmic reticulum
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 48 – 75 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 81 – 100 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 120 – 137 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 149 – 168 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 175 – 193 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 199 – 216 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 228 – 246 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 252 – 270 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSMMUG00000007279, Expressed in cerebellar cortex and 22 other tissues |
Family & Domainsi
Sequence similaritiesi
Belongs to the PIGC family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG3059, Eukaryota |
GeneTreei | ENSGT00390000005496 |
HOGENOMi | CLU_024002_0_0_1 |
OMAi | SYHAFVL |
OrthoDBi | 1241278at2759 |
TreeFami | TF314325 |
Family and domain databases
InterProi | View protein in InterPro IPR009450, Plno_GlcNAc_GPI2 |
PANTHERi | PTHR12982, PTHR12982, 1 hit |
Pfami | View protein in Pfam PF06432, GPI2, 1 hit |
PIRSFi | PIRSF016104, GPI2, 1 hit |
i Sequence
Sequence statusi: Complete.
F7FCE6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCAQPVTSTK EVKWQKVLYE RQPFPDNYVD RRFLEELRKN IHARKYQYWA
60 70 80 90 100
VVFESSVVIQ QLCSVCVFVV IWWYMDEGLL APHWLFGTGL ASSLIGYVLF
110 120 130 140 150
DLIDGGEGRK KSGQTRWADL KSALVFITFT YGFSPVLKTL TESVSTDTIY
160 170 180 190 200
AMSVFMLLGH LIFFDYGANA AIVSSTLSLN MAIFASVCLA SRLPRSLHAF
210 220 230 240 250
IMVTFAIQIF ALWPMLQKKL KACTPRSYVG VTLLFAFSAL GGLLSISAVG
260 270 280 290
AILFALLLMS ISCLCPFYLI RLQLFKENIH GPWDEAEIKE DLSRFLS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JU470844 mRNA Translation: AFH27648.1 JV043443 mRNA Translation: AFI33514.1 JV047379 mRNA Translation: AFI37450.1 JV047382 mRNA Translation: AFI37453.1 JV635546 mRNA Translation: AFJ70886.1 |
RefSeqi | NP_001248179.1, NM_001261250.1 XP_014978754.1, XM_015123268.1 |
Genome annotation databases
Ensembli | ENSMMUT00000010165; ENSMMUP00000009539; ENSMMUG00000007279 ENSMMUT00000094935; ENSMMUP00000079226; ENSMMUG00000007279 |
GeneIDi | 705657 |
KEGGi | mcc:705657 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JU470844 mRNA Translation: AFH27648.1 JV043443 mRNA Translation: AFI33514.1 JV047379 mRNA Translation: AFI37450.1 JV047382 mRNA Translation: AFI37453.1 JV635546 mRNA Translation: AFJ70886.1 |
RefSeqi | NP_001248179.1, NM_001261250.1 XP_014978754.1, XM_015123268.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9544.ENSMMUP00000009539 |
Genome annotation databases
Ensembli | ENSMMUT00000010165; ENSMMUP00000009539; ENSMMUG00000007279 ENSMMUT00000094935; ENSMMUP00000079226; ENSMMUG00000007279 |
GeneIDi | 705657 |
KEGGi | mcc:705657 |
Organism-specific databases
CTDi | 5279 |
VGNCi | VGNC:75986, PIGC |
Phylogenomic databases
eggNOGi | KOG3059, Eukaryota |
GeneTreei | ENSGT00390000005496 |
HOGENOMi | CLU_024002_0_0_1 |
OMAi | SYHAFVL |
OrthoDBi | 1241278at2759 |
TreeFami | TF314325 |
Enzyme and pathway databases
UniPathwayi | UPA00196 |
Gene expression databases
Bgeei | ENSMMUG00000007279, Expressed in cerebellar cortex and 22 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR009450, Plno_GlcNAc_GPI2 |
PANTHERi | PTHR12982, PTHR12982, 1 hit |
Pfami | View protein in Pfam PF06432, GPI2, 1 hit |
PIRSFi | PIRSF016104, GPI2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7FCE6_MACMU | |
Accessioni | F7FCE6Primary (citable) accession number: F7FCE6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 57 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |