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Entry version 63 (02 Jun 2021)
Sequence version 2 (02 Dec 2020)
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Protein
Submitted name:

Envoplakin

Gene
N/A
Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
EnvoplakinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOrnithorhynchus anatinus (Duckbill platypus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9258 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataOrnithorhynchidaeOrnithorhynchus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002279 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSOANG00000001866, Expressed in endometrium and 8 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9258.ENSOANP00000002963

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini413 – 470SH3InterPro annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 38DisorderedSequence analysisAdd BLAST38
Regioni353 – 378DisorderedSequence analysisAdd BLAST26
Regioni1576 – 1601DisorderedSequence analysisAdd BLAST26
Regioni1779 – 1806DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili43 – 63Sequence analysisAdd BLAST21
Coiled coili87 – 107Sequence analysisAdd BLAST21
Coiled coili112 – 132Sequence analysisAdd BLAST21
Coiled coili175 – 195Sequence analysisAdd BLAST21
Coiled coili378 – 398Sequence analysisAdd BLAST21
Coiled coili478 – 498Sequence analysisAdd BLAST21
Coiled coili513 – 533Sequence analysisAdd BLAST21
Coiled coili548 – 568Sequence analysisAdd BLAST21
Coiled coili905 – 939Sequence analysisAdd BLAST35
Coiled coili963 – 997Sequence analysisAdd BLAST35
Coiled coili1016 – 1057Sequence analysisAdd BLAST42
Coiled coili1084 – 1118Sequence analysisAdd BLAST35
Coiled coili1151 – 1185Sequence analysisAdd BLAST35
Coiled coili1202 – 1222Sequence analysisAdd BLAST21
Coiled coili1255 – 1282Sequence analysisAdd BLAST28
Coiled coili1322 – 1342Sequence analysisAdd BLAST21
Coiled coili1387 – 1444Sequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1784 – 1803Pro residuesSequence analysisAdd BLAST20

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153578

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001780_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7F6U6

Identification of Orthologs from Complete Genome Data

More...
OMAi
GPSQINY

TreeFam database of animal gene trees

More...
TreeFami
TF342779

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1290.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041615, Desmoplakin_SH3
IPR030460, Envoplakin
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 1 hit
PTHR23169:SF7, PTHR23169:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00681, Plectin, 4 hits
PF17902, SH3_10, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00250, PLEC, 7 hits
SM00150, SPEC, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF75399, SSF75399, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F7F6U6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFKGLSKGSP GKGSPKGSPA RGSPKGSPSK HSRASTQELA LLISRMQANA
60 70 80 90 100
DQVERDILES QKRLQLDRAS SEQCQALQYQ QETGRDLKEA ETLLKDLFLD
110 120 130 140 150
VDKAKRMKHP QAAEIEKDIK QLHERVTQEC AEYRALYEKV VLPPGVGTKV
160 170 180 190 200
DWSRLLEQKQ VRVCEGQFGP GMPELEQQIA EHNVLQKEIE AYGQTLLNLS
210 220 230 240 250
GPDAATIKNQ YRDLLKAASW RGQSLGSLYT HLQGCTRQLN ALADQQRRIL
260 270 280 290 300
QQDWSDQMAD PAGLRREYEH FKSHELLAQE QCVNQLEDDG ERMIELNHPA
310 320 330 340 350
VGPIQVHQEA LKTEWQNFLN LCICQESQLQ RVEDYRRFQD DADSADQVLR
360 370 380 390 400
KLSSDLDTKL SPDGRGTPGT PSDLGRPLES EEKQLIMAEK TVQDLQRRCQ
410 420 430 440 450
DIAPLPLRRT PPSQPLRVDA ICDWDAGDVQ LLRGETYTLK DNSHPETWLV
460 470 480 490 500
QGPGGESKPA PAACFSIPGP NPEAVARARR LEAELWALKQ KKAAVESSGP
510 520 530 540 550
DPAAGSGRID PHAQKVLTRL TGLEKDLTQT EQEILGRLRA PLSRHAPVED
560 570 580 590 600
LTARLRGQEA TARQLQGLGA DKEAAQRECE ALLSSRPAGP AALQLPVALN
610 620 630 640 650
NVKNKFSDVQ ALCALYGEKA KASLELEQQI QKSDQLIQTF EAALGQEAPL
660 670 680 690 700
AAGPGALQDR AGELQRQRRE LQAQQACVLG LHRGLKATEQ GCGALQNNFR
710 720 730 740 750
EFCQDLPRQR QRVQRLTDRY HAVADQLDTQ EKTIQDASLT YQQFKNSNEN
760 770 780 790 800
LTSWLAHLPC NSARPNDGPS QVNYKLQAQK RLVQEIQNKE EDRNTVLRLS
810 820 830 840 850
RDLQGALQDY ELQTDKYRCS LDPTLTVPAP KKPSISPLQE SIQAQEKAVV
860 870 880 890 900
QRFTEVAAQN RQQLSQLEFA RKVMEKKESS EDVQEASEGS LGAERPVGAG
910 920 930 940 950
TEAVAATLKG QLEKERQRVA QVQQELEEQR AQLLLLKTQR PVERLEEKEV
960 970 980 990 1000
VEVYRDPGLE SGLSEMRAQL EAEGKERARV RAELEAAARE VARLEGQRKA
1010 1020 1030 1040 1050
VQPELLTKEV TQVERDPGLE AEAAQLRAAA QQLREEGAAA GTQLERLREE
1060 1070 1080 1090 1100
LLTLERRPAP AVQEKVVVKE VIKLEKDPEM VRAAQALQRQ LEEDGCRRQE
1110 1120 1130 1140 1150
AEEAALRLRD RIRELEQLIG AVEPKVVVKE VKKVEQDPGL QRESARLRSL
1160 1170 1180 1190 1200
LDEERGRNAA LCGELQDLRA RLSLAEQRKP RVEVKERVHE TFRVDPETER
1210 1220 1230 1240 1250
EIARLQREVR ETAAKRSAVE KEVERVLPEL SALRARQPKL EYQEVVQEVV
1260 1270 1280 1290 1300
KHEKSPEVLR EIDRLKAQLN ELVNAHGRAQ EQLIRLGGER DEWKRERSKV
1310 1320 1330 1340 1350
ETKTVTKEVV RHENDPVLEK EAERLRLEVQ GAAQKRRAAE AALFEVQSRL
1360 1370 1380 1390 1400
LLLERRRPEE RVVVQEVVVT RRDPQLQEEH SRLSRGLDEA AGQRRLLERE
1410 1420 1430 1440 1450
AQQLRAAVAE DEARLTFQEE RNKRLAAEKE LRRLGLRLRE LRERPPPVAP
1460 1470 1480 1490 1500
EKVITEEVVQ LERDPEVERA VGALRRELEA EKQHGAELGR ERVGLQGRIE
1510 1520 1530 1540 1550
ALRQTKGQEK TVYKEVVRVE RDRALEGERA RVWEQLSQER AARQGREGTV
1560 1570 1580 1590 1600
RQLQGRVERA EAQGRTWARE EADLQRARQQ ASQERAQLER ETRELERQRQ
1610 1620 1630 1640 1650
QAVQELREEA RLADRKSESE RQRKALCGQE LARLEVAILA EKDQIYEKER
1660 1670 1680 1690 1700
TLRDLQAKIN REELGQETQT CETNLSTTIS VLDPDTGGDL SPCEAYQRGI
1710 1720 1730 1740 1750
VDRAQYAQLR ALECDWEEVT TSALGGEASV LLDKKSGRRY SIQEALRCRR
1760 1770 1780 1790 1800
VTEDELRLYR SGRLPVAEFA LLVSGEAGPH PAAPGGAGSP PISPGPARPP
1810 1820 1830 1840 1850
ARCFSPGPGG DAFPIAGVYD PAADSKCGIR AAMARGLLDP ITGQKLLEAQ
1860 1870 1880 1890 1900
AATGGIVDLL TRERFSVHKA MERGLVDDTS TQRLLNAQKA FTGIEDPVTK
1910 1920 1930 1940 1950
KRLAVGEAVQ KGWMPRESAL PHLQVQHLTG GLIDPKRAGR IPVSQALQMG
1960 1970 1980 1990 2000
MISGELAELL QDESGYEKEL TDPVSKERLS YKEAMGRCRQ DPLTGLLLLP
2010
AAPGGCLPCC SPAPSRRLL
Length:2,019
Mass (Da):226,834
Last modified:December 2, 2020 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2161C3FDA5EA23D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A6I8N9B1A0A6I8N9B1_ORNAN
Envoplakin
2,028Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8NUC4A0A6I8NUC4_ORNAN
Envoplakin
2,048Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSOANT00000002964; ENSOANP00000002963; ENSOANG00000001866

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9258.ENSOANP00000002963

Genome annotation databases

EnsembliENSOANT00000002964; ENSOANP00000002963; ENSOANG00000001866

Phylogenomic databases

eggNOGiKOG0516, Eukaryota
GeneTreeiENSGT00940000153578
HOGENOMiCLU_001780_0_0_1
InParanoidiF7F6U6
OMAiGPSQINY
TreeFamiTF342779

Gene expression databases

BgeeiENSOANG00000001866, Expressed in endometrium and 8 other tissues

Family and domain databases

Gene3Di3.90.1290.10, 1 hit
InterProiView protein in InterPro
IPR041615, Desmoplakin_SH3
IPR030460, Envoplakin
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
PANTHERiPTHR23169, PTHR23169, 1 hit
PTHR23169:SF7, PTHR23169:SF7, 1 hit
PfamiView protein in Pfam
PF00681, Plectin, 4 hits
PF17902, SH3_10, 1 hit
SMARTiView protein in SMART
SM00250, PLEC, 7 hits
SM00150, SPEC, 2 hits
SUPFAMiSSF75399, SSF75399, 2 hits
PROSITEiView protein in PROSITE
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7F6U6_ORNAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7F6U6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 2, 2020
Last modified: June 2, 2021
This is version 63 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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