ALX1

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	134 – 193	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterior/posterior pattern specification Source: Ensembl
embryonic limb morphogenesis Source: Ensembl
embryonic skeletal system morphogenesis Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
neural crest cell migration Source: InterPro
neural tube closure Source: Ensembl
positive regulation of epithelial to mesenchymal transition Source: Ensembl
roof of mouth development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental proteinPROSITE-ProRule annotationSAAS annotation, DNA-bindingPROSITE-ProRule annotationSAAS annotation

Molecular function

Developmental proteinPROSITE-ProRule annotationSAAS annotation, DNA-bindingPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: ALX homeobox 1Imported
Gene namesⁱ	Name:ALX1Imported
Organismⁱ	Monodelphis domestica (Gray short-tailed opossum)Imported
Taxonomic identifierⁱ	13616 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Metatheria › Didelphimorphia › Didelphidae › Didelphinae › Monodelphis
Proteomesⁱ	UP000002280 Componentⁱ: Chromosome 8

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMODG00000020494

Bgeeⁱ

ENSMODG00000020494

Interactionⁱ

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	13616.ENSMODP00000025643

STRINGⁱ

13616.ENSMODP00000025643

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	132 – 192	HomeoboxInterPro annotationAdd BLAST		61
Domainⁱ	308 – 321	OARInterPro annotationAdd BLAST		14

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	308 – 321	OARPROSITE-ProRule annotationAdd BLAST		14

Sequence similaritiesⁱ

Belongs to the paired homeobox family.SAAS annotation

Keywords - Domainⁱ

HomeoboxPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG0490 Eukaryota ENOG410YIJ3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140809
InParanoidⁱ	F7F534
KEGG Orthology (KO) More...KOⁱ	K09334
OMAⁱ	HVSLNNF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B1L
TreeFamⁱ	TF350743

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR033209 ALX1 IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR003654 OAR_dom
PANTHERⁱ	PTHR24329:SF359 PTHR24329:SF359, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF03826 OAR, 1 hit
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS50803 OAR, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

F7F534-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIMDFLSEKF ALKNQPSKNS DFYMGAGGTL EHVMETLDNE TFYSKTSASK 
        60         70         80         90        100
CVQAFNPLQR AEHHVRLDRT SPCQENNVNY GITKVEGQPL HTELNRAMDN 
       110        120        130        140        150
CNSLRMSPVK GMQEKGELDE LGDKCDSNVS SSKKRRHRTT FTSLQLEELE 
       160        170        180        190        200
KVFQKTHYPD VYVREQLALR TELTEARVQV WFQNRRAKWR KRERYGQIQQ 
       210        220        230        240        250
AKSHFAATYD ISVLPRTDSY PQIQNNMWAG NATGGSVVTS CMLPRDTSSC 
       260        270        280        290        300
MTPYSHTPRT DSGYTGFSNH QNQFGHVPLN NFFTDSLLSG ATNGHAFETK 
       310        320 
PEFERRSSSI AVLRMKAKEH TANISWAM

Length:328

Mass (Da):37,442

Last modified:January 9, 2013 - v2

Checksum:ⁱF7348E76025185DD

GO

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_001364457.2, XM_001364420.3

RefSeqⁱ

XP_001364457.2, XM_001364420.3

Genome annotation databases

Ensemblⁱ	ENSMODT00000026099; ENSMODP00000025643; ENSMODG00000020494
GeneIDⁱ	100014051
KEGGⁱ	mdo:100014051

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
F7F534	ALX homeobox protein 1		HUMAN		326
ALX homeobox 1		PANTR		326
ALX homeobox 1		PANPA		326
ALX homeobox 1		GORGO		326
UPI0006B0C52E		Apteryx australis mantelli		328
+160

Protein	Similar proteins		Species	Score	Length
F7F534	ALX homeobox protein 1		HUMAN		326
ALX homeobox 1		PANTR		326
ALX homeobox 1		PANPA		326
ALX homeobox 1		GORGO		326
UPI00071C8094		CALPG		328
+185

Cross-referencesⁱ

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_001364457.2, XM_001364420.3

RefSeqⁱ

XP_001364457.2, XM_001364420.3

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	13616.ENSMODP00000025643

STRINGⁱ

13616.ENSMODP00000025643

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMODT00000026099; ENSMODP00000025643; ENSMODG00000020494
GeneIDⁱ	100014051
KEGGⁱ	mdo:100014051

Organism-specific databases

CTDⁱ	8092

CTDⁱ

8092

Phylogenomic databases

eggNOGⁱ	KOG0490 Eukaryota ENOG410YIJ3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140809
InParanoidⁱ	F7F534
KEGG Orthology (KO) More...KOⁱ	K09334
OMAⁱ	HVSLNNF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B1L
TreeFamⁱ	TF350743

Gene expression databases

Bgeeⁱ	ENSMODG00000020494

Bgeeⁱ

ENSMODG00000020494

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR033209 ALX1 IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR003654 OAR_dom
PANTHERⁱ	PTHR24329:SF359 PTHR24329:SF359, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF03826 OAR, 1 hit
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS50803 OAR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F7F534_MONDO
Accessionⁱ	F7F534Primary (citable) accession number: F7F534
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 27, 2011
	Last sequence update:	January 9, 2013
	Last modified:	July 18, 2018
	This is version 54 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F7F534 (F7F534_MONDO)

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ALX homeobox 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Golgi apparatus

Nucleus

Other locations

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ