UniProtKB - F7F534 (F7F534_MONDO)
Protein
ALX homeobox protein 1
Gene
ALX1
Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 134 – 193 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- anterior/posterior pattern specification Source: Ensembl
- embryonic limb morphogenesis Source: Ensembl
- embryonic skeletal system morphogenesis Source: GO_Central
- negative regulation of transcription, DNA-templated Source: GO_Central
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neural crest cell migration Source: InterPro
- neural tube closure Source: Ensembl
- positive regulation of epithelial to mesenchymal transition Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- roof of mouth development Source: Ensembl
Keywordsi
Molecular function | Developmental proteinPROSITE-ProRule annotationARBA annotation, DNA-bindingPROSITE-ProRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: ALX homeobox protein 1ARBA annotationAlternative name(s): Cartilage homeoprotein 1ARBA annotation |
Gene namesi | Name:ALX1Imported |
Organismi | Monodelphis domestica (Gray short-tailed opossum)Imported |
Taxonomic identifieri | 13616 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Metatheria › Didelphimorphia › Didelphidae › Monodelphis |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotationARBA annotation
Golgi apparatus
- Golgi apparatus Source: Ensembl
Nucleus
- nuclear body Source: Ensembl
- nuclear chromatin Source: GO_Central
Other locations
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMODG00000020494, Expressed in brain and 14 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 132 – 192 | HomeoboxInterPro annotationAdd BLAST | 61 | |
Domaini | 308 – 321 | OARInterPro annotationAdd BLAST | 14 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 308 – 321 | OARPROSITE-ProRule annotationAdd BLAST | 14 |
Sequence similaritiesi
Belongs to the paired homeobox family.ARBA annotation
Keywords - Domaini
HomeoboxPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000158251 |
HOGENOMi | CLU_047013_0_1_1 |
InParanoidi | F7F534 |
OMAi | PPCVTSY |
OrthoDBi | 738339at2759 |
TreeFami | TF350743 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR033209, ALX1 IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003654, OAR_dom |
PANTHERi | PTHR24329:SF359, PTHR24329:SF359, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F7F534-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIMDFLSEKF ALKNQPSKNS DFYMGAGGTL EHVMETLDNE TFYSKTSASK
60 70 80 90 100
CVQAFNPLQR AEHHVRLDRT SPCQENNVNY GITKVEGQPL HTELNRAMDN
110 120 130 140 150
CNSLRMSPVK GMQEKGELDE LGDKCDSNVS SSKKRRHRTT FTSLQLEELE
160 170 180 190 200
KVFQKTHYPD VYVREQLALR TELTEARVQV WFQNRRAKWR KRERYGQIQQ
210 220 230 240 250
AKSHFAATYD ISVLPRTDSY PQIQNNMWAG NATGGSVVTS CMLPRDTSSC
260 270 280 290 300
MTPYSHTPRT DSGYTGFSNH QNQFGHVPLN NFFTDSLLSG ATNGHAFETK
310 320
PEFERRSSSI AVLRMKAKEH TANISWAM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A5F8HDE6 | A0A5F8HDE6_MONDO | ALX homeobox protein 1 | ALX1 | 326 | Annotation score: |
Sequence databases
RefSeqi | XP_001364457.2, XM_001364420.3 |
Genome annotation databases
Ensembli | ENSMODT00000026099; ENSMODP00000025643; ENSMODG00000020494 |
GeneIDi | 100014051 |
KEGGi | mdo:100014051 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_001364457.2, XM_001364420.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 13616.ENSMODP00000025643 |
Genome annotation databases
Ensembli | ENSMODT00000026099; ENSMODP00000025643; ENSMODG00000020494 |
GeneIDi | 100014051 |
KEGGi | mdo:100014051 |
Organism-specific databases
CTDi | 8092 |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000158251 |
HOGENOMi | CLU_047013_0_1_1 |
InParanoidi | F7F534 |
OMAi | PPCVTSY |
OrthoDBi | 738339at2759 |
TreeFami | TF350743 |
Gene expression databases
Bgeei | ENSMODG00000020494, Expressed in brain and 14 other tissues |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR033209, ALX1 IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003654, OAR_dom |
PANTHERi | PTHR24329:SF359, PTHR24329:SF359, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7F534_MONDO | |
Accessioni | F7F534Primary (citable) accession number: F7F534 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | January 9, 2013 | |
Last modified: | February 10, 2021 | |
This is version 72 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |