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Protein

Phospholipid-transporting ATPase

Gene

ATP8B1

Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPaseUniRule annotation (EC:3.6.3.1UniRule annotation)
Gene namesi
Name:ATP8B1Imported
OrganismiOrnithorhynchus anatinus (Duckbill platypus)Imported
Taxonomic identifieri9258 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataOrnithorhynchidaeOrnithorhynchus
Proteomesi
  • UP000002279 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei116 – 133HelicalUniRule annotationAdd BLAST18
Transmembranei139 – 161HelicalUniRule annotationAdd BLAST23
Transmembranei339 – 362HelicalUniRule annotationAdd BLAST24
Transmembranei387 – 408HelicalUniRule annotationAdd BLAST22
Transmembranei952 – 973HelicalUniRule annotationAdd BLAST22
Transmembranei985 – 1005HelicalUniRule annotationAdd BLAST21
Transmembranei1035 – 1054HelicalUniRule annotationAdd BLAST20
Transmembranei1074 – 1092HelicalUniRule annotationAdd BLAST19
Transmembranei1099 – 1126HelicalUniRule annotationAdd BLAST28
Transmembranei1146 – 1169HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSOANG00000001718 Expressed in 5 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi9258.ENSOANP00000002749

Structurei

3D structure databases

ProteinModelPortaliF7F079
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 145PhoLip_ATPase_NInterPro annotationAdd BLAST79
Domaini921 – 1175PhoLip_ATPase_CInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili841 – 861Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410ITKD Eukaryota
ENOG410XPYK LUCA
GeneTreeiENSGT00910000144008
InParanoidiF7F079
KOiK01530
OrthoDBiEOG091G0139
TreeFamiTF300654

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR030346 ATP8B1
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF48 PTHR24092:SF48, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

F7F079-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSERDLETT FEEDFQPNDE VVPYSDDETE DELEVSEPAE EPEQNRINRA
60 70 80 90 100
TEETRETLRK DCMWHVKAND RDFHIQPQYL KTTLFCLKES KYANNAIKTY
110 120 130 140 150
KYNAITFLPM NLYEQFKRAA NFYFLILLIL QSIPQITTLA WYTTLVPLLL
160 170 180 190 200
VLGITAVKDL VDDVARHRMD NEINNRTCEV IKDGRFKNAK WKEIQVGDVI
210 220 230 240 250
RLKKNDFIPA DILLLSSSEP HSLCYVETAE LDGETNLKFK MSLDVTDKLL
260 270 280 290 300
QRENSLAEFD GFVECEEPNN RLDKFTGTLT WRGERYPLDA DKILLRGCVI
310 320 330 340 350
RNTDFCHGMV IFAGADTKIM KNSGKTRFKR TKIDYLMNYM VYTIFVLLIL
360 370 380 390 400
ISAGLAIGHA YWEAQIGNYS WYLYDGENYT PSYRGFFNFW GCIIVLNTMV
410 420 430 440 450
PISLYVSVEI IRLGQSYFIN WDLQMYYPEK DTGAKARTTT LNEQLGQIHY
460 470 480 490 500
VFSDKTGTLT QNIMTFKKCC INGQIYGDPR DTGRHSRARM EPVDLSWSTY
510 520 530 540 550
ADGKLDFYDH YLIEQIQGGK DSEVRHFFFL LAVCHTVMVD RTDGQLNYQA
560 570 580 590 600
ASPDEGALVT AARNFGFAFL SRTQNTITIS EMGIERTYNV LAILDFNSER
610 620 630 640 650
KRMSIIVRAP EGNIRLYCKG ADTVIYERLH PMNPTKQETQ DALDIFASET
660 670 680 690 700
LRTLCLCYKD IDDNEYMEWN KKFTAASLAP ANRDELLDKV YEEIEKDLVL
710 720 730 740 750
LGATAIEDKL QDGVPETISK LGKADIKIWV LTGDKKETAE NIGFACELLT
760 770 780 790 800
EETSICYGED INALLQTRLE NQRNRSGMCA KFTHANTANE PFFPSGGNRA
810 820 830 840 850
LIITGSWLNE ILLEKKTKKS NILKLKFPRT EEERRMRTQS KKRLEINKEQ
860 870 880 890 900
QQKNFVDLAC ECNAVICCRV TPKQKAMVVD LVRKYKKAIT LAIGDGANDV
910 920 930 940 950
NMIKTAHIGV GISGQEGMQA VMSSDYSIAQ FRYLQRLLLV HGRWSYIRMC
960 970 980 990 1000
KFLRYFFYKN FAFTLVHFWY SFFNGFSAQT AYEDWLITLY NVLYSSLPVL
1010 1020 1030 1040 1050
LVGLLDQDVS DKLSLRFPSL YIVGQRDLLF NYKKFFISLF HGILTSMILF
1060 1070 1080 1090 1100
FIPYGAYLQT MGQDGEAPSD YQSFAVTVAS ALIITVNFQI GLDTSYWTFV
1110 1120 1130 1140 1150
NAFSIFGSIA LYFGIMFDFH SAGIHVLFPS AFQFTGTAPN ALRQPYLWLT
1160 1170 1180 1190 1200
IILTVAVCLL PIIALRFITM TIWPSESDKI QKNRKRYKAE EQWKRRQSVF
1210 1220 1230 1240 1250
RRGASARRSA YAFSHQRGYA DLISSGRSIR KKRSPLDSVL GEAAQFEGPA

LFRKIDIS
Length:1,258
Mass (Da):144,592
Last modified:January 9, 2013 - v2
Checksum:iB54BE4B481A7D9D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAPN01197283 Genomic DNA No translation available.
AAPN01197284 Genomic DNA No translation available.
AAPN01197285 Genomic DNA No translation available.
AAPN01197286 Genomic DNA No translation available.
RefSeqiXP_001510687.1, XM_001510637.3

Genome annotation databases

EnsembliENSOANT00000002750; ENSOANP00000002749; ENSOANG00000001718
GeneIDi100079760
KEGGioaa:100079760

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAPN01197283 Genomic DNA No translation available.
AAPN01197284 Genomic DNA No translation available.
AAPN01197285 Genomic DNA No translation available.
AAPN01197286 Genomic DNA No translation available.
RefSeqiXP_001510687.1, XM_001510637.3

3D structure databases

ProteinModelPortaliF7F079
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9258.ENSOANP00000002749

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOANT00000002750; ENSOANP00000002749; ENSOANG00000001718
GeneIDi100079760
KEGGioaa:100079760

Organism-specific databases

CTDi5205

Phylogenomic databases

eggNOGiENOG410ITKD Eukaryota
ENOG410XPYK LUCA
GeneTreeiENSGT00910000144008
InParanoidiF7F079
KOiK01530
OrthoDBiEOG091G0139
TreeFamiTF300654

Gene expression databases

BgeeiENSOANG00000001718 Expressed in 5 organ(s), highest expression level in liver

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR030346 ATP8B1
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF48 PTHR24092:SF48, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF7F079_ORNAN
AccessioniPrimary (citable) accession number: F7F079
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: January 9, 2013
Last modified: November 7, 2018
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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