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Protein
Submitted name:

Laminin subunit beta 2

Gene

LAMB2

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Laminin subunit beta 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMB2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9483 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008225 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9483.ENSCJAP00000006767

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0994 Eukaryota
ENOG410XPEG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156060

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7EPJ1

Identification of Orthologs from Complete Genome Data

More...
OMAi
QIQIYNT

Database of Orthologous Groups

More...
OrthoDBi
65841at2759

TreeFam database of animal gene trees

More...
TreeFami
TF312903

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR013015 Laminin_IV_B
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053 Laminin_EGF, 13 hits
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 13 hits
SM00136 LamNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01248 EGF_LAM_1, 5 hits
PS50027 EGF_LAM_2, 13 hits
PS51116 LAMININ_IVB, 1 hit
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F7EPJ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELTSREGGR GQPLPWELRL GLLLSVLAAT LAQVPVPDLP GCSRGSCYPA
60 70 80 90 100
TGDLLVGRAD RLTASSTCGL NGPQPYCIVS HLQDEKKCFL CDSRRPFSAR
110 120 130 140 150
DNPHSHRIQN VVTSFAPQRR AAWWQSENGI PAVTIQLDLE AEFHFTHLIM
160 170 180 190 200
TFKTFRPAAM LVERSADFGH TWHVYRYFSY DCGADFPGVP LAPPRHWDDV
210 220 230 240 250
VCESRYSEIE PSTEGEVIYR VLDPAIPITD PYSSRIQNLL KITNLRVNLT
260 270 280 290 300
RLHTLGDNLL DPRREIREKY YYALYELVVR GNCFCYGHAS ECAPAPGAPA
310 320 330 340 350
HAEGMVHGAC ICKHNTRGLN CEQCQDFYHD LPWHPAEDGH SHACRKCECH
360 370 380 390 400
GHTHSCHFDM AIYLASGNVS GGVCDGCQHN TAGRHCELCR PFFYRDPTKD
410 420 430 440 450
LRDPAACRPC DCDPMGSQDG GRCDSHDDPA LGLVSGQCRC KEHVVGTRCQ
460 470 480 490 500
QCRDGFFGLS ISDPLGCQRC QCNARGTVPG STPCNPNSGT CYCKRLVTGR
510 520 530 540 550
GCDRCLPGHW GLSHDLLGCR PCDCDVGGAL DPQCDEATGQ CHCRQHMVGR
560 570 580 590 600
RCEQVQPGYF RPFLDHLTWE AEDTQGQVLD VVERLVTPGE TPSWTGSGFV
610 620 630 640 650
RLREGQALEF LVPSVPKAMD YDLLLRLEPQ VPEQWAELEL TVQRPGPVPA
660 670 680 690 700
HSLCGHVLPK DDHIQGTLQP HARYMVFPNP VCLEPGISYK LHLKLVRTGG
710 720 730 740 750
RAQPETPYSG PGLLIDSLVL LPRVLVLEVF SGGDAAALER RATFERYQCH
760 770 780 790 800
EEGLVPSKTS TSEACAPLLI SLSTLIYNGA LPCQCNPQGS LSSECNPHGG
810 820 830 840 850
QCLCKPGVVG RGCDVCAPGY YGFGPTGCQA CQCSHEGALS SLCEKTSGQC
860 870 880 890 900
PCRTGAFGLR CDRCQRGQWG FPSCRPCVCN GHADECDTHT GACLGCRDHT
910 920 930 940 950
GGEHCERCIA GFHGDPRLPY GGQCRPCPCP EGPGSQRHFA TSCHRDEFSQ
960 970 980 990 1000
QIVCHCRAGY TGLRCEACAP GHFGDPSRPG GQCQLCECSG NIDPMDPDAC
1010 1020 1030 1040 1050
DPHTGQCLRC LHHTEGPQCA HCKPGFYGQA ARQSCHRCTC NLLGTNPQQC
1060 1070 1080 1090 1100
PSPDQCHCDP SSGQCPCLPN VQGPSCNRCA PNFWNLTSGH GCQPCACHPS
1110 1120 1130 1140 1150
RARGPTCNEF TGQCHCHAGF GGRTCSECQE LHWGDPGLQC RACDCDSHGI
1160 1170 1180 1190 1200
DTPQCHRSTG HCSCRPGVSG VRCDQCARGF SGIFPACYPC HACFGDWDRV
1210 1220 1230 1240 1250
VQDLAARTRR LEQRAQELQQ TGVLGAFESS FWHMQEKLGI VQGIVGARNT
1260 1270 1280 1290 1300
SAASTAQLVE ATEELRREIG EATEHLTQLE AELTDVQDEN FNANHALSGL
1310 1320 1330 1340 1350
ERDGLALNLT LRQLDQHLDL LKHSNFLGAY DSIHHAYRQS VEAERRANTS
1360 1370 1380 1390 1400
ALAVPSPVSN SASTRRQTEA LMDAQKEDFN SKHMANQRAL DKLSALTHTL
1410 1420 1430 1440 1450
SLTGINELVC GTPGDAPCAT SPCGGAGCRD EDGQFRCGGL SCNGAAATAD
1460 1470 1480 1490 1500
LALGRARHTQ AELQRALVEG GSILSRVAET RRQASKAQQR AQAALDKANA
1510 1520 1530 1540 1550
SRGQVEQANQ ELRELIQSVK DFLNQEGADP DSIEMVATRV LELSIPASAE
1560 1570 1580 1590 1600
QIQHLAGAIA ERVRSLADVD VILARTVGDV RRAEQLLQDA RRARSRADNE
1610 1620 1630 1640 1650
KQKAETVQAA LEEAQRAQGV AQGAIWGAVA DTQDTEQTLH QVQERMAGAE
1660 1670 1680 1690 1700
QALSSAGERA QQLDALLEAL KLKRAGNSLA ASTAEETAGS AQGRAQEAEK
1710 1720 1730 1740 1750
LLRGPLGDQY QTVKALAERK AQGVLAAQAR AEQLRDEAQD LLQAAQDKLQ
1760 1770 1780 1790
RLQELEGTYE ENERALEDKA AQLDGLEARM RSVLQAINLQ VQIYNTCQ
Length:1,798
Mass (Da):195,748
Last modified:June 20, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7EC69202870D1942
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCJAT00000007146; ENSCJAP00000006767; ENSCJAG00000003674

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000006767

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCJAT00000007146; ENSCJAP00000006767; ENSCJAG00000003674

Phylogenomic databases

eggNOGiKOG0994 Eukaryota
ENOG410XPEG LUCA
GeneTreeiENSGT00940000156060
InParanoidiF7EPJ1
OMAiQIQIYNT
OrthoDBi65841at2759
TreeFamiTF312903

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR013015 Laminin_IV_B
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00053 Laminin_EGF, 13 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 13 hits
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS01248 EGF_LAM_1, 5 hits
PS50027 EGF_LAM_2, 13 hits
PS51116 LAMININ_IVB, 1 hit
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7EPJ1_CALJA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7EPJ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: June 20, 2018
Last modified: January 16, 2019
This is version 55 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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