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Entry version 51 (12 Aug 2020)
Sequence version 3 (11 Dec 2019)
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Protein

TAFH domain-containing protein

Gene

TAF4

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TAFH domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAF4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca mulatta (Rhesus macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9544 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006718 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:98455, TAF4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMMUG00000008696, Expressed in spermatid and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9544.ENSMMUP00000011401

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini588 – 685TAFHInterPro annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni66 – 202DisorderedSequence analysisAdd BLAST137
Regioni241 – 339DisorderedSequence analysisAdd BLAST99
Regioni381 – 423DisorderedSequence analysisAdd BLAST43
Regioni477 – 497DisorderedSequence analysisAdd BLAST21
Regioni1013 – 1046DisorderedSequence analysisAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili980 – 1000Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi82 – 128Pro-richSequence analysisAdd BLAST47
Compositional biasi173 – 187Pro-richSequence analysisAdd BLAST15
Compositional biasi243 – 296Pro-richSequence analysisAdd BLAST54
Compositional biasi382 – 396Pro-richSequence analysisAdd BLAST15
Compositional biasi408 – 423PolarSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TAF4 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2341, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011620

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010576_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7E5W7

TreeFam database of animal gene trees

More...
TreeFami
TF316520

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08045, TAF4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.20.10, 1 hit
1.20.120.1110, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009072, Histone-fold
IPR007900, TAF4
IPR037249, TAFH/NHR1_dom_sf
IPR003894, TAFH_NHR1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05236, TAF4, 1 hit
PF07531, TAFH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00549, TAFH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF158553, SSF158553, 1 hit
SSF47113, SSF47113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51119, TAFH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F7E5W7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGSDLLDE VFFNSEVDEK VVSDLVGSLE SQLAASAAHH HHLAPRTPEV
60 70 80 90 100
RAAAAGALGN HVVSGSPAGA AGAGPAAPAE GAPGAAPEPP PAGRARPGGG
110 120 130 140 150
GPRRPGPPSP RRPLVPAGPA PPAAKLRPPP EGSAGACAPV PAAAAVAAGP
160 170 180 190 200
EPAPAGPAKP AGPTALAARA GPGPGPGPGP GPGPGKPAGP GAAQTLNGSA
210 220 230 240 250
ALLNSHHAAA PAVSLVNNGP AALLPLPKPA APGTVIQTPP FVGAAAPPAP
260 270 280 290 300
AAPSPPAAPA PAAPAAAPPP PPPAPATLAR PPGHPAGPPT AAPAAPPPAA
310 320 330 340 350
AQNGGSAGAA PAPAPAAGGP AGVSGQPGPG AAAAAPAPGV KAESPKTVVQ
360 370 380 390 400
AAPPAAQTLA ASGPASTAAS MVIGPTMQGA LPSPAAVPPP APGTPTGLPK
410 420 430 440 450
GAAGAVTQSL PRTPTATTSG IRATLTPTVL APRLPQPPQN PTNIQNFQLP
460 470 480 490 500
PGMVLVRSEN GQLLMIPQQA LAQMQAQAHA QPQTTMAPRP ATPTSAPPVQ
510 520 530 540 550
ISTVQAPGTP IIARQVTPTT IIKQVSQAQT TVQPSATLQR SPGVQPQLVL
560 570 580 590 600
GGAAQTASLG TATAVQTGTP QRTVPGATAT SSAATETMEN VKKCKNFLST
610 620 630 640 650
LIKLASSGKQ STETAANVKE LVQNLLDGKI EAEDFTSRLY RELNSSPQPY
660 670 680 690 700
LVPFLKRSLP ALRQLTPDSA AFIQQSQQQP PPPASQATTA LTAVVLSSSV
710 720 730 740 750
QRTAGKTAAT VTSALQPPVL SLTQPTQVGV GKQGQPTPLV IQQPPKPGAL
760 770 780 790 800
IRPPQVTLTQ TPMVALRQPH NRIMLTTPQQ IQLNPLQPVP VVKPAVLPGT
810 820 830 840 850
KALSAVSAQA AAAQKNKLKE PGGGSFRDDD DINDVASMAG VNLSEESARI
860 870 880 890 900
LATNSELVGT LTRSCKDETF LLQAPLQRRI LEIGKKHGIT ELHPDVVSYV
910 920 930 940 950
SHATQQRLQN LVEKISETAQ QKNFSYKDDD RYEQASDVRA QLKFFEQLDQ
960 970 980 990 1000
IEKQRKDEQE REILMRAAKS RSRQEDPEQL RLKQKAKEMQ QQELAQMRQR
1010 1020 1030 1040 1050
DANLTALAAI GPRKKRKVDC PGPGSGAEGS GPGSVVPGSS GVGAPRQFTR
1060 1070 1080
QRITRVNLRD LIFCLENERE TSHSLLLYKA FLK
Length:1,083
Mass (Da):109,839
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31A974CF5D3C00CF
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMMUT00000012154; ENSMMUP00000011401; ENSMMUG00000008696

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000011401

Genome annotation databases

EnsembliENSMMUT00000012154; ENSMMUP00000011401; ENSMMUG00000008696

Organism-specific databases

VGNCiVGNC:98455, TAF4

Phylogenomic databases

eggNOGiKOG2341, Eukaryota
GeneTreeiENSGT00390000011620
HOGENOMiCLU_010576_2_1_1
InParanoidiF7E5W7
TreeFamiTF316520

Gene expression databases

BgeeiENSMMUG00000008696, Expressed in spermatid and 20 other tissues

Family and domain databases

CDDicd08045, TAF4, 1 hit
Gene3Di1.10.20.10, 1 hit
1.20.120.1110, 1 hit
InterProiView protein in InterPro
IPR009072, Histone-fold
IPR007900, TAF4
IPR037249, TAFH/NHR1_dom_sf
IPR003894, TAFH_NHR1
PfamiView protein in Pfam
PF05236, TAF4, 1 hit
PF07531, TAFH, 1 hit
SMARTiView protein in SMART
SM00549, TAFH, 1 hit
SUPFAMiSSF158553, SSF158553, 1 hit
SSF47113, SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS51119, TAFH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7E5W7_MACMU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7E5W7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: August 12, 2020
This is version 51 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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