Cytochrome P450 family 1 subfamily B member 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• estrogen 16-alpha-hydroxylase activity Source: Ensembl
• heme binding Source: Ensembl
• iron ion binding Source: InterPro
• monooxygenase activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: Ensembl

GO - Biological processⁱ

• angiogenesis Source: Ensembl
• arachidonic acid metabolic process Source: Ensembl
• cellular aromatic compound metabolic process Source: Ensembl
• cellular response to hydrogen peroxide Source: Ensembl
• cellular response to organic cyclic compound Source: Ensembl
• collagen fibril organization Source: Ensembl
• endothelial cell-cell adhesion Source: Ensembl
• endothelial cell migration Source: Ensembl
• estrogen metabolic process Source: Ensembl
• intrinsic apoptotic signaling pathway in response to oxidative stress Source: Ensembl
• membrane lipid catabolic process Source: Ensembl
• negative regulation of cell adhesion mediated by integrin Source: Ensembl
• negative regulation of cell migration Source: Ensembl
• negative regulation of cell population proliferation Source: Ensembl
• negative regulation of NF-kappaB transcription factor activity Source: Ensembl
• nitric oxide biosynthetic process Source: Ensembl
• positive regulation of angiogenesis Source: Ensembl
• positive regulation of apoptotic process Source: Ensembl
• positive regulation of receptor signaling pathway via JAK-STAT Source: Ensembl
• positive regulation of vascular endothelial growth factor production Source: Ensembl
• regulation of reactive oxygen species metabolic process Source: Ensembl
• response to toxic substance Source: Ensembl
• retinal blood vessel morphogenesis Source: Ensembl
• retinal metabolic process Source: Ensembl
• retinol metabolic process Source: Ensembl
• toxin metabolic process Source: Ensembl
• trabecular meshwork development Source: Ensembl
• xenobiotic metabolic process Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Coiled coil

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MPAPQQTASS DTAPPRSMAT SLSLDDPLLP ISLSTQQTTL LLFLSALAAV 
        60         70         80         90        100
HVGQWLLRQR RRQPGCAPPG PFAWPLIGNA AAMGPAPHLA FARLARRYGD 
       110        120        130        140        150
VFQIRLGSCP VVVLNGERAI RQALVQQGAA FADRPPFASF RVVSGGHSLA 
       160        170        180        190        200
FSQYSEHWKV HRRAAHSTMR AFSTRQPRSR RVLEGHVLGE ARELVALLVR 
       210        220        230        240        250
GSAGGAFLDP VPLTVVAVAN VMSAVCFGCR YNHDDAEFLE LLSHNEKFGR 
       260        270        280        290        300
TVGAGSLVDV LPWLQLFPNP VRTAFREFEQ LNRNFSNFVL NKFLSHRESL 
       310        320        330        340        350
RPGAAPRDMM DAFILSAGKE AAEGSGDGGA RLDMEYVPGT VTDIFGASQD 
       360        370        380        390        400
TLSTALQWLL ILFTRYPEVQ ARVQAELDQV VGRDRLPCLD DQPKLPYVMA 
       410        420        430        440        450
FLYEAMRFSS FVPVTIPHAT TANASVLGYH IPKDTVVFVN QWSVNHDPVK 
       460        470        480        490        500
WPNPEDFDPA RFLDKDGSIN RDLASSVMIF SVGKRRCIGE ELSKMQLFLF 
       510        520        530        540        550
ISILAHECNI KANPDELSKM DFHYGLTIKP KSFKINVTLR ESMELLDSAV 
       560
QKLQAEEDSQ                                             

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

3D structure databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ