Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 40 (11 Dec 2019)
Sequence version 2 (10 Apr 2019)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Centlein

Gene

CNTLN

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CentleinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNTLNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 23

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:16694 CNTLN

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F7E0M4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000020007 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24
Regioni41 – 77DisorderedSequence analysisAdd BLAST37
Regioni424 – 455DisorderedSequence analysisAdd BLAST32
Regioni482 – 518DisorderedSequence analysisAdd BLAST37
Regioni866 – 914DisorderedSequence analysisAdd BLAST49

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili102 – 122Sequence analysisAdd BLAST21
Coiled coili166 – 193Sequence analysisAdd BLAST28
Coiled coili201 – 274Sequence analysisAdd BLAST74
Coiled coili282 – 316Sequence analysisAdd BLAST35
Coiled coili461 – 481Sequence analysisAdd BLAST21
Coiled coili524 – 586Sequence analysisAdd BLAST63
Coiled coili615 – 663Sequence analysisAdd BLAST49
Coiled coili680 – 808Sequence analysisAdd BLAST129
Coiled coili997 – 1021Sequence analysisAdd BLAST25
Coiled coili1029 – 1063Sequence analysisAdd BLAST35
Coiled coili1086 – 1141Sequence analysisAdd BLAST56
Coiled coili1163 – 1225Sequence analysisAdd BLAST63
Coiled coili1287 – 1317Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 19Pro-richSequence analysisAdd BLAST19
Compositional biasi51 – 65PolyampholyteSequence analysisAdd BLAST15
Compositional biasi482 – 498PolarSequence analysisAdd BLAST17
Compositional biasi499 – 513PolyampholyteSequence analysisAdd BLAST15
Compositional biasi871 – 892PolarSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHKZ Eukaryota
ENOG410XRNE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000034932

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7E0M4

KEGG Orthology (KO)

More...
KOi
K16467

TreeFam database of animal gene trees

More...
TreeFami
TF329190

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038810 CNTLN

The PANTHER Classification System

More...
PANTHERi
PTHR18957 PTHR18957, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F7E0M4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAARSPPSPL PPPPERRLGP WSPRVGRGAV VHTVSCEATG LAGGAREGVV
60 70 80 90 100
DKSDISLRGE EGSGGRRGPG RAAPAQAPLL SAPAGSRRLE GISVEEAMVT
110 120 130 140 150
RTQLLEDELS SLKEELALCQ ADKEFVWSLW KRLQVTHPDL TQAVSLVVER
160 170 180 190 200
EKQKSEAKDR KVLEILQVKD AKIQELEQRE SELKQEINDL VKRKITVDEE
210 220 230 240 250
NAFLRKEFSD LQKKYKDKSQ EIKDTKECVQ NKEEQNRMVI KDLEEENEKL
260 270 280 290 300
STRCADLLND LEKLRKEEAH WRKEKYSVDA KIKAFEDSLI EARKEIEVSQ
310 320 330 340 350
SKYNALSLQL NNKETELMQK DMDITLVRKE LQELQNLYKQ NSAHTAQQAE
360 370 380 390 400
LIQQLQVLNM DTQKVLRNQE DVHIAESISY QKLYNELHIC FETTKSSEAM
410 420 430 440 450
LRQSVVSLQD QLFQKEQENA KLKENLQGSQ GAPYPYPQEN DSDHSEQISQ
460 470 480 490 500
RPSLSSLETL MVSQKSEIEY LQEKLKIANE KLSENRSTNN GSSEKSILTS
510 520 530 540 550
ADGKHKEPPV KRSRSLSLKS SFTDSEELRK LRNAERKIEN LEKALQLKSQ
560 570 580 590 600
ENDELRDAHE KRKERLQMLQ TNYRAVKEQL KQWEEGSGMT EIRKIKRADP
610 620 630 640 650
QQLRQEDSGA VWNELAYFKR ENQELIIQKM NLQEELDKLK VQISLDKATI
660 670 680 690 700
QELNTRLAEK REEQLFRYGE DDGVKKSTPE KNEKEMLEQT LQKVIELENR
710 720 730 740 750
VKSFETRSRK LKEGNKKLIK ENDFLKSLIR QQQEDAVARE KELEQLQNES
760 770 780 790 800
KDVEKDKTEL QVKISELERE VTSLRRQVAE ANGLRNENEE LMNSMEKLQH
810 820 830 840 850
SADKVKSEMT TTKMRSGQYD CKTTTTKVKL KAAKKKCPVG RYHTVLNHSI
860 870 880 890 900
KVMSNVFENL NKDGWEDVSE SSSDSETQTS QNVGTIIVET SQKISPIEDG
910 920 930 940 950
RDQKESDQTQ DSQIQQKEIV QIYSNIDGKT PKDYQYKNAK KPTFQKKNDN
960 970 980 990 1000
IQKSSHTTLP TRVNREKWKN ITAQKSSSSI ILLRERIISL QQQNSVLQNA
1010 1020 1030 1040 1050
RKTAELSVKE YKEVNEKLLQ QQQASDQRFQ TSRQTIKKLN LDLAALRKEK
1060 1070 1080 1090 1100
EDLLKKLESS SEITSLTEEV SQVTVPRMQV TSLGTSRSMD LEMKQLQCKL
1110 1120 1130 1140 1150
KNATNELTKQ LSNVKSLKFE LLAKEEHIKE MHEKLSRMER DITMKRHLIE
1160 1170 1180 1190 1200
DLKFRQKVNL ESNESVNEML ENLEKKVQTL TEECSNKKVS IDSLKQRLSV
1210 1220 1230 1240 1250
AVREKSQYEQ MYQKTKEELE KKDLKLNILV SKVNETESAM AEIETAASKH
1260 1270 1280 1290 1300
LQGLALQSEQ ALEGAQKKLL LATEKVEEFT VFVKALVKEL QTDVHSIRRH
1310 1320 1330 1340 1350
IRELKKMRKN RDAYKTSTHK AQTLAASILN ISQSDLEEIL DTEDEVEIER
1360 1370 1380 1390 1400
TKMDAENDKE WLLYIQKLLE GQLPFASYLL EAVLEKINEK KKLVEEYFTI

MKDIR
Length:1,405
Mass (Da):162,349
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F3362C67083CE69
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2H2C6A0A3Q2H2C6_HORSE
Centlein
CNTLN
1,320Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HDA5A0A3Q2HDA5_HORSE
Centlein
CNTLN
1,379Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_014590975.1, XM_014735489.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000021463; ENSECAP00000017677; ENSECAG00000020007

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100052128

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecb:100052128

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_014590975.1, XM_014735489.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF7E0M4

Genome annotation databases

EnsembliENSECAT00000021463; ENSECAP00000017677; ENSECAG00000020007
GeneIDi100052128
KEGGiecb:100052128

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54875
VGNCiVGNC:16694 CNTLN

Phylogenomic databases

eggNOGiENOG410IHKZ Eukaryota
ENOG410XRNE LUCA
GeneTreeiENSGT00440000034932
InParanoidiF7E0M4
KOiK16467
TreeFamiTF329190

Gene expression databases

BgeeiENSECAG00000020007 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

InterProiView protein in InterPro
IPR038810 CNTLN
PANTHERiPTHR18957 PTHR18957, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7E0M4_HORSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7E0M4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: December 11, 2019
This is version 40 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again