UniProtKB - F7DYA5 (F7DYA5_HORSE)
Protein
Submitted name:
Uncharacterized protein
Gene
PCDH15
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- calcium ion binding Source: InterPro
GO - Biological processi
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- inner ear development Source: InterPro
- sensory perception of sound Source: InterPro
Keywordsi
Ligand | CalciumPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Uncharacterized proteinImported |
Gene namesi | Name:PCDH15Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Subcellular locationi
Plasma Membrane
- plasma membrane Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
- stereocilium Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1387 – 1409 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_5023944268 | 27 – 1792 | Sequence analysisAdd BLAST | 1766 |
Proteomic databases
PaxDbi | F7DYA5 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000019573, Expressed in brainstem and 10 other tissues |
ExpressionAtlasi | F7DYA5, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 153 – 270 | CadherinInterPro annotationAdd BLAST | 118 | |
Domaini | 283 – 400 | CadherinInterPro annotationAdd BLAST | 118 | |
Domaini | 401 – 521 | CadherinInterPro annotationAdd BLAST | 121 | |
Domaini | 522 – 628 | CadherinInterPro annotationAdd BLAST | 107 | |
Domaini | 629 – 729 | CadherinInterPro annotationAdd BLAST | 101 | |
Domaini | 731 – 831 | CadherinInterPro annotationAdd BLAST | 101 | |
Domaini | 832 – 938 | CadherinInterPro annotationAdd BLAST | 107 | |
Domaini | 939 – 1047 | CadherinInterPro annotationAdd BLAST | 109 | |
Domaini | 1049 – 1156 | CadherinInterPro annotationAdd BLAST | 108 | |
Domaini | 1157 – 1271 | CadherinInterPro annotationAdd BLAST | 115 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1432 – 1455 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 1588 – 1792 | DisorderedSequence analysisAdd BLAST | 205 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1487 – 1514 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1436 – 1455 | Pro-richSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1596 – 1652 | AcidicSequence analysisAdd BLAST | 57 | |
Compositional biasi | 1653 – 1688 | PolyampholyteSequence analysisAdd BLAST | 36 | |
Compositional biasi | 1689 – 1704 | AcidicSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1705 – 1724 | PolyampholyteSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1745 – 1760 | PolarSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000156675 |
HOGENOMi | CLU_009081_0_0_1 |
InParanoidi | F7DYA5 |
TreeFami | TF326779 |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR041149, EC_dom IPR030718, Protocadherin-15 |
PANTHERi | PTHR24028:SF11, PTHR24028:SF11, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 8 hits PF18432, ECD, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 11 hits |
SUPFAMi | SSF49313, SSF49313, 10 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 4 hits PS50268, CADHERIN_2, 10 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
F7DYA5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLQQFYLWRW LASGIILGSL FAISLGQYDD DWQYEDCKLA RGGPPATIVA
60 70 80 90 100
IDEESRNGTI LVDNMLIKGT AGGPDPTIEL SLKDNVDYWV LLDPVKQMLF
110 120 130 140 150
LNSTGRVLDR DPPMNIHSIV VQVQCINKKV GTVIYHEVRI VVRDRNDNSP
160 170 180 190 200
TFKHESYYAT VNELTPVGTT IFTGFAGDNG ATDIDDGPNG QIEYVIQYNP
210 220 230 240 250
ADPTSNDTFE IPLMLTGNVV LRKRLNYEDK TRYFVIIQAN DRAQNLNERR
260 270 280 290 300
TTTTTLTVDV LDGDDLGPMF LPCVLVPNTR DCRPLTYQAA IPELRTPEEL
310 320 330 340 350
NPIIVTPPIQ AIDQDRNIQP PSDRPGVLYS ILVGTPEDYP RFFHMHPRTA
360 370 380 390 400
ELSLLEPVNR DFHQKFDLVI KAEQDNGHPL PAFASLHIEI LDENNQSPYF
410 420 430 440 450
TVPSYQGYIL ESAPVGATIS DSLNLTTPLR IVALDKDIED VPPGGVPTKD
460 470 480 490 500
PELHLFLNDY TSVFTVTQTG VTRYLTLLQP VDREDQQTYT FSITAFDGVQ
510 520 530 540 550
ESEPVIVNIR VMDANDNTPT FPEISYDVYV YTDMSPGDSV IQLTAVDADE
560 570 580 590 600
GSNGEITYEI LVGAQGDFII NKTTGLITIA PGVELIVGRT YALTVQAADN
610 620 630 640 650
APPAERRHSI CTVYIEVLPP NNQSPPRFPQ LMYSLEISEA MRIGAVLLNL
660 670 680 690 700
QATDREGDPI TYAIENGDPQ RVFNLSENTG ILTLGKALDR ESTDRYILIV
710 720 730 740 750
TASDGRPDGT STATVNVVVT DVNDNAPVFD PYLPRNLSVV EEEANAFVGQ
760 770 780 790 800
VRATDPDAGI NGQVHYSLGN FNNLFRITSN GSIYTAVKLN REVRDYYELV
810 820 830 840 850
VVATDGAVHP RHSTLTLAIK VLDIDDNSPV FTNSTYSVVV EENLPAGTTF
860 870 880 890 900
LQIEAKDVDL GANVSYRIRS PEVKHFFALH PFTGELSLLR SLDYESFPDQ
910 920 930 940 950
EASITFLVEA FDIYGTMPPG IATVTVIVKD MNDYPPVFSK RIYKGMVAPD
960 970 980 990 1000
AVKGTPITTV YAEDADPPGL PASRVRYRVD DVQFPYPASI FDVEEDSGKV
1010 1020 1030 1040 1050
ITRVNLNEEP TTIFKLVVVA FDDGEPVMSS SATVKILVLH PGEIPRFTQE
1060 1070 1080 1090 1100
EYRPPPVSEL ATRGTMVGVI SAAAINQSIV YSIVSGNEED MFGINNITGV
1110 1120 1130 1140 1150
IYVNAPLDYE TRTSYVLRVQ ADSLEVVLAN LRVPSKSNTA KIYIEIQDEN
1160 1170 1180 1190 1200
DHPPVFQKKF YIGGVSEDAR MFASVLRVKA TDKDTGNYSA MAYRLIIPPI
1210 1220 1230 1240 1250
KEGKEGFVVE TYTGLIKTAM LFHNMRRSYF KFQVIATDDY GKGLSGKADV
1260 1270 1280 1290 1300
LVSVVNQLDM QVIVSNVPPT LVEKKIEELT EILDRYVQEQ IPGAKVVVES
1310 1320 1330 1340 1350
IGARRHGDAF SLEDYTKCDL TVYAIDPQTN RAIDRNELFK FLDGKLLDIN
1360 1370 1380 1390 1400
KDFQPYYGEG GRILEIRTPE AVTSIKKRGE SLGYTEGALL ALAFIIILCC
1410 1420 1430 1440 1450
IPAILVVLVS YRQFKVRQAE CTKTARIQSA MPAAKPAAPA PAPVAAPPPP
1460 1470 1480 1490 1500
PPPPGVHLYE ELGDSTMHKY EMPQYGSRRR LLPPAGHEEY GEVLGEAEEE
1510 1520 1530 1540 1550
YEEEEEKAKK IKKPKVEIRE PSEEEEVVVT IEKPPAAEPT YTTWKRARIF
1560 1570 1580 1590 1600
PMIFKKVRGL ADRRGVIDLE GEEWQRRLEE EDKDYLKLTL DQDEATESTV
1610 1620 1630 1640 1650
ESEEESSSDY TEYSEEESEF SESETTEEES ESETPSEEEE SSTPESEESE
1660 1670 1680 1690 1700
STESEGEKAR KNIFLARRRP VAEEVKEVKG RKEEPPEEPE EEPQVDEEEE
1710 1720 1730 1740 1750
HPAEGEASEL APVEEPRDLE SQDITEEGSA ESASVERSVE SEEESESGSS
1760 1770 1780 1790
SSSSESQSGG PWGFRVPEYD TSKNAKHKKS PRASSEGYNT AL
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2I303 | A0A3Q2I303_HORSE | Uncharacterized protein | PCDH15 | 1,933 | Annotation score: | ||
A0A3Q2IFG0 | A0A3Q2IFG0_HORSE | Uncharacterized protein | PCDH15 | 1,938 | Annotation score: | ||
A0A5F5PY73 | A0A5F5PY73_HORSE | Uncharacterized protein | PCDH15 | 1,896 | Annotation score: | ||
A0A5F5Q1T4 | A0A5F5Q1T4_HORSE | Uncharacterized protein | PCDH15 | 1,943 | Annotation score: | ||
A0A3Q2H0A7 | A0A3Q2H0A7_HORSE | Uncharacterized protein | PCDH15 | 1,913 | Annotation score: | ||
A0A3Q2H3K3 | A0A3Q2H3K3_HORSE | Uncharacterized protein | PCDH15 | 1,655 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000020785; ENSECAP00000017079; ENSECAG00000019573 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F7DYA5 |
Genome annotation databases
Ensembli | ENSECAT00000020785; ENSECAP00000017079; ENSECAG00000019573 |
Phylogenomic databases
GeneTreei | ENSGT00940000156675 |
HOGENOMi | CLU_009081_0_0_1 |
InParanoidi | F7DYA5 |
TreeFami | TF326779 |
Gene expression databases
Bgeei | ENSECAG00000019573, Expressed in brainstem and 10 other tissues |
ExpressionAtlasi | F7DYA5, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR041149, EC_dom IPR030718, Protocadherin-15 |
PANTHERi | PTHR24028:SF11, PTHR24028:SF11, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 8 hits PF18432, ECD, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 11 hits |
SUPFAMi | SSF49313, SSF49313, 10 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 4 hits PS50268, CADHERIN_2, 10 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7DYA5_HORSE | |
Accessioni | F7DYA5Primary (citable) accession number: F7DYA5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 11, 2019 | |
Last modified: | February 10, 2021 | |
This is version 60 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |