UniProtKB - F7DXK7 (F7DXK7_HORSE)
Protein
Serine/threonine-protein kinase receptor
Gene
ACVR2B
Organism
Equus caballus (Horse)
Status
Functioni
Catalytic activityi
- EC:2.7.11.30ARBA annotation
- ATP + L-threonyl-[receptor-protein] = ADP + H+ + O-phospho-L-threonyl-[receptor-protein]UniRule annotationARBA annotationEC:2.7.11.30UniRule annotationARBA annotation
Cofactori
Protein has several cofactor binding sites:GO - Molecular functioni
- activin-activated receptor activity Source: GO_Central
- activin binding Source: GO_Central
- ATP binding Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: GO_Central
GO - Biological processi
- activin receptor signaling pathway Source: GO_Central
- cellular response to growth factor stimulus Source: GO_Central
- protein phosphorylation Source: GO_Central
Keywordsi
Molecular function | Kinase, ReceptorUniRule annotation, Serine/threonine-protein kinaseUniRule annotationARBA annotation, Transferase |
Ligand | ATP-bindingUniRule annotationARBA annotation, MagnesiumUniRule annotation, ManganeseUniRule annotationARBA annotation, Metal-bindingUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase receptorUniRule annotation (EC:2.7.11.30UniRule annotation) |
Gene namesi | Name:ACVR2BImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:15039, ACVR2B |
Subcellular locationi
Other locations
- Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation
Plasma Membrane
- activin receptor complex Source: GO_Central
- plasma membrane Source: GO_Central
Other locations
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 138 – 160 | HelicalUniRule annotationAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_5018741922 | 23 – 512 | Serine/threonine-protein kinase receptorSequence analysisAdd BLAST | 490 |
Proteomic databases
PaxDbi | F7DXK7 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000019616, Expressed in inner cell mass and 19 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 190 – 480 | Protein kinaseInterPro annotationAdd BLAST | 291 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.UniRule annotationARBA annotation
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixUniRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000156210 |
HOGENOMi | CLU_000288_8_4_1 |
InParanoidi | F7DXK7 |
TreeFami | TF352876 |
Family and domain databases
InterProi | View protein in InterPro IPR000472, Activin_recp IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF00069, Pkinase, 1 hit |
PRINTSi | PR00653, ACTIVIN2R |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F7DXK7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTAPWAALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE
60 70 80 90 100
GEQDKRLHCY ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY
110 120 130 140 150
FCCCEGNFCN ERFTHLPEAG GPEVTYEPPP TAPTLLTVLA YSLLPIGGLS
160 170 180 190 200
LIILLAFWMY RHRKPPYGHV DIHEDPGPPP PSPLVGLKPL QLLEIKARGR
210 220 230 240 250
FGCVWKAQLM NDFVAVKIFP LQDKQSWQSE REIFSTPGMK HENLLQFIAA
260 270 280 290 300
EKRGSNLEVE LWLITAFHDK GSLTDYLKGN IITWNELCHV AETMSRGLSY
310 320 330 340 350
LHEDVPWCRG EGHKPSIAHR DFKSKNVLLK SDLTAVLADF GLAVRFEPGK
360 370 380 390 400
PPGDTHGQVG TRRYMAPEVL EGAINFQRDA FLRIDMYAMG LVLWELVSRC
410 420 430 440 450
KAADGPVDEY MLPFEEEIGQ HPSLEELQEV VVHKKMRPAI KDHWLKHPGL
460 470 480 490 500
AQLCVTIEEC WDHDAEARLS AGCVEERVSL IRRSVNGTTS DCLVSLVTSV
510
TNVDLPPKES SI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F5PYR0 | A0A5F5PYR0_HORSE | Serine/threonine-protein kinase rec... | ACVR2B | 577 | Annotation score: | ||
A0A5F5PNB6 | A0A5F5PNB6_HORSE | Serine/threonine-protein kinase rec... | ACVR2B | 551 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000021126; ENSECAP00000017382; ENSECAG00000019616 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F7DXK7 |
Genome annotation databases
Ensembli | ENSECAT00000021126; ENSECAP00000017382; ENSECAG00000019616 |
Organism-specific databases
VGNCi | VGNC:15039, ACVR2B |
Phylogenomic databases
GeneTreei | ENSGT00940000156210 |
HOGENOMi | CLU_000288_8_4_1 |
InParanoidi | F7DXK7 |
TreeFami | TF352876 |
Gene expression databases
Bgeei | ENSECAG00000019616, Expressed in inner cell mass and 19 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000472, Activin_recp IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF00069, Pkinase, 1 hit |
PRINTSi | PR00653, ACTIVIN2R |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7DXK7_HORSE | |
Accessioni | F7DXK7Primary (citable) accession number: F7DXK7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | February 10, 2021 | |
This is version 61 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |