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Protein

V-type proton ATPase subunit a

Gene

atp6v0a4

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transportUniRule annotation, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-XTR-1222556 ROS, RNS production in phagocytes
R-XTR-77387 Insulin receptor recycling
R-XTR-917977 Transferrin endocytosis and recycling
R-XTR-983712 Ion channel transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit aUniRule annotation
Gene namesi
Name:atp6v0a4Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-493197 atp6v0a4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei392 – 421HelicalUniRule annotationAdd BLAST30
Transmembranei441 – 460HelicalUniRule annotationAdd BLAST20
Transmembranei539 – 560HelicalUniRule annotationAdd BLAST22
Transmembranei566 – 590HelicalUniRule annotationAdd BLAST25
Transmembranei635 – 656HelicalUniRule annotationAdd BLAST22
Transmembranei772 – 794HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiF7DPH0

Expressioni

Gene expression databases

BgeeiENSXETG00000011571
ExpressionAtlasiF7DPH0 baseline

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000025320

Structurei

3D structure databases

ProteinModelPortaliF7DPH0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2189 Eukaryota
COG1269 LUCA
GeneTreeiENSGT00390000004941
InParanoidiF7DPH0
OMAiFLNTFKM
OrthoDBiEOG091G01BI
TreeFamiTF300346

Family and domain databases

InterProiView protein in InterPro
IPR002490 V-ATPase_116kDa_su
IPR026028 V-type_ATPase_116kDa_su_euka
PANTHERiPTHR11629 PTHR11629, 1 hit
PfamiView protein in Pfam
PF01496 V_ATPase_I, 3 hits
PIRSFiPIRSF001293 ATP6V0A1, 3 hits

Sequencei

Sequence statusi: Complete.

F7DPH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLFRSEEM SLTQLILQVE AGYCCIAELG ELGLVQFRDL NASVNSFQRR
60 70 80 90 100
FVNEVRRCEN MERILREIIG TTGTGGINAC EPSACAGHLQ TRALLPNITI
110 120 130 140 150
CTGMGPIIQN ARDLGFVLRN GTGRCNFFYS VLYMGPCVLQ AEANLPDDFF
160 170 180 190 200
SEDTSSLLEL RTIPSAAAAG KLGFTAGVIN RERMATFERL LWRVCRGNIY
210 220 230 240 250
LKYTELDTAL EDPVTKEEVK KNVFIIFYQG DQLKLKIKKI CDGSVTGILC
260 270 280 290 300
QMKKISNSKH FIVMCNCHCV FMCNCHCVCP FPFPALLVLT PDTTPQYPFI
310 320 330 340 350
PHSHWVYVMC NCHCVFMCNC HCVCPFPFPA LLVLTPDTTP QYPFIPHSHW
360 370 380 390 400
VYSYLDPPTF NRTNKFTSGF QNIVNAYGVG SYREMNPTPY TIITFPFLFA
410 420 430 440 450
VMFGDCGHGS VMLGFALWMV LNEKQLLASK TDNEIWNTFF GGRYLILLMS
460 470 480 490 500
IFSIYTGFIY NDCFSKSFDI FGSSWRVRPM FINKTWNDNL VHQGLQLQLD
510 520 530 540 550
PAVPGVYSGN PYPFGIDPIW NIAQNKLTFL NSYKMKMSVV MGITQMVFGV
560 570 580 590 600
MLGLLNHINF KRPINIILQF IPEMIFIICL FGYLVFMIIF KWCKYDVHSS
610 620 630 640 650
QGAPSILIHF INMFLFNYSD PTNAPLYEHQ KEVQTFLVIF ALIAVPWMLL
660 670 680 690 700
IKPFVLRANH LKAQRMLQSS SGPEDHAELT DVENAHANHK SKKEEHGGGD
710 720 730 740 750
HGGGHGEHGE EFDFGDIFVH QAIHTIEYCL GCISNTASYL RLWALSLAHA
760 770 780 790 800
QLSEVLWTMV MHQGLSIGGY GGLIGVFIIF AAFAVLTVAI LLVMEGLSAF
810 820 830
LHALRLHWVE FQNKFYAGTG HLFSPFSFQS ILEGTDNE
Length:838
Mass (Da):94,615
Last modified:July 27, 2011 - v1
Checksum:iD6185B3C11DDC7AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01102827 Genomic DNA No translation available.
AAMC01102828 Genomic DNA No translation available.
AAMC01102829 Genomic DNA No translation available.
AAMC01102830 Genomic DNA No translation available.
AAMC01102831 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSXETT00000025320; ENSXETP00000025320; ENSXETG00000011571

Similar proteinsi

Entry informationi

Entry nameiF7DPH0_XENTR
AccessioniPrimary (citable) accession number: F7DPH0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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