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Protein
Submitted name:

Ubiquitin C

Gene

ubc

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein tag Source: GO_Central
  • ubiquitin protein ligase binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-110312 Translesion synthesis by REV1
R-XTR-110314 Recognition of DNA damage by PCNA-containing replication complex
R-XTR-110320 Translesion Synthesis by POLH
R-XTR-1169091 Activation of NF-kappaB in B cells
R-XTR-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-XTR-1253288 Downregulation of ERBB4 signaling
R-XTR-1295596 Spry regulation of FGF signaling
R-XTR-1358803 Downregulation of ERBB2:ERBB3 signaling
R-XTR-168638 NOD1/2 Signaling Pathway
R-XTR-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-XTR-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-XTR-174113 SCF-beta-TrCP mediated degradation of Emi1
R-XTR-174154 APC/C:Cdc20 mediated degradation of Securin
R-XTR-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-XTR-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-XTR-179409 APC-Cdc20 mediated degradation of Nek2A
R-XTR-182971 EGFR downregulation
R-XTR-187577 SCF(Skp2)-mediated degradation of p27/p21
R-XTR-195253 Degradation of beta-catenin by the destruction complex
R-XTR-201681 TCF dependent signaling in response to WNT
R-XTR-202424 Downstream TCR signaling
R-XTR-209543 p75NTR recruits signalling complexes
R-XTR-209560 NF-kB is activated and signals survival
R-XTR-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-XTR-2173788 Downregulation of TGF-beta receptor signaling
R-XTR-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-XTR-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-XTR-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-XTR-2467813 Separation of Sister Chromatids
R-XTR-2559580 Oxidative Stress Induced Senescence
R-XTR-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-XTR-2559585 Oncogene Induced Senescence
R-XTR-2565942 Regulation of PLK1 Activity at G2/M Transition
R-XTR-2672351 Stimuli-sensing channels
R-XTR-2871837 FCERI mediated NF-kB activation
R-XTR-3134975 Regulation of innate immune responses to cytosolic DNA
R-XTR-3322077 Glycogen synthesis
R-XTR-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-XTR-3769402 Deactivation of the beta-catenin transactivating complex
R-XTR-382556 ABC-family proteins mediated transport
R-XTR-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-XTR-450302 activated TAK1 mediates p38 MAPK activation
R-XTR-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-XTR-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-XTR-4641257 Degradation of AXIN
R-XTR-4641258 Degradation of DVL
R-XTR-4641263 Regulation of FZD by ubiquitination
R-XTR-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-XTR-5357905 Regulation of TNFR1 signaling
R-XTR-5357956 TNFR1-induced NFkappaB signaling pathway
R-XTR-5358346 Hedgehog ligand biogenesis
R-XTR-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-XTR-5607764 CLEC7A (Dectin-1) signaling
R-XTR-5610780 Degradation of GLI1 by the proteasome
R-XTR-5610785 GLI3 is processed to GLI3R by the proteasome
R-XTR-5632684 Hedgehog 'on' state
R-XTR-5654726 Negative regulation of FGFR1 signaling
R-XTR-5654727 Negative regulation of FGFR2 signaling
R-XTR-5654732 Negative regulation of FGFR3 signaling
R-XTR-5654733 Negative regulation of FGFR4 signaling
R-XTR-5655862 Translesion synthesis by POLK
R-XTR-5656121 Translesion synthesis by POLI
R-XTR-5656169 Termination of translesion DNA synthesis
R-XTR-5668541 TNFR2 non-canonical NF-kB pathway
R-XTR-5675221 Negative regulation of MAPK pathway
R-XTR-5675482 Regulation of necroptotic cell death
R-XTR-5676590 NIK-->noncanonical NF-kB signaling
R-XTR-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-XTR-5685942 HDR through Homologous Recombination (HRR)
R-XTR-5687128 MAPK6/MAPK4 signaling
R-XTR-5689603 UCH proteinases
R-XTR-5689877 Josephin domain DUBs
R-XTR-5689880 Ub-specific processing proteases
R-XTR-5689896 Ovarian tumor domain proteases
R-XTR-5689901 Metalloprotease DUBs
R-XTR-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-XTR-5696394 DNA Damage Recognition in GG-NER
R-XTR-5696395 Formation of Incision Complex in GG-NER
R-XTR-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-XTR-5696400 Dual Incision in GG-NER
R-XTR-6781823 Formation of TC-NER Pre-Incision Complex
R-XTR-6782135 Dual incision in TC-NER
R-XTR-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-XTR-6783310 Fanconi Anemia Pathway
R-XTR-6804756 Regulation of TP53 Activity through Phosphorylation
R-XTR-6804757 Regulation of TP53 Degradation
R-XTR-6804760 Regulation of TP53 Activity through Methylation
R-XTR-6807004 Negative regulation of MET activity
R-XTR-68827 CDT1 association with the CDC6:ORC:origin complex
R-XTR-68949 Orc1 removal from chromatin
R-XTR-69017 CDK-mediated phosphorylation and removal of Cdc6
R-XTR-69229 Ubiquitin-dependent degradation of Cyclin D1
R-XTR-69231 Cyclin D associated events in G1
R-XTR-69481 G2/M Checkpoints
R-XTR-69541 Stabilization of p53
R-XTR-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-XTR-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-XTR-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-XTR-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-XTR-8856825 Cargo recognition for clathrin-mediated endocytosis
R-XTR-8856828 Clathrin-mediated endocytosis
R-XTR-8863795 Downregulation of ERBB2 signaling
R-XTR-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-XTR-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-XTR-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-XTR-8939902 Regulation of RUNX2 expression and activity
R-XTR-8941858 Regulation of RUNX3 expression and activity
R-XTR-8948747 Regulation of PTEN localization
R-XTR-8948751 Regulation of PTEN stability and activity
R-XTR-8951664 Neddylation
R-XTR-901032 ER Quality Control Compartment (ERQC)
R-XTR-9010553 Regulation of expression of SLITs and ROBOs
R-XTR-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
R-XTR-9020702 Interleukin-1 signaling
R-XTR-9033241 Peroxisomal protein import
R-XTR-912631 Regulation of signaling by CBL
R-XTR-917729 Endosomal Sorting Complex Required For Transport (ESCRT)
R-XTR-917937 Iron uptake and transport
R-XTR-936440 Negative regulators of DDX58/IFIH1 signaling
R-XTR-937039 IRAK1 recruits IKK complex
R-XTR-937042 IRAK2 mediated activation of TAK1 complex
R-XTR-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-XTR-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-XTR-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-XTR-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ubiquitin CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ubcImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-6066017 ubc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F7DNS3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSXETG00000017136 Expressed in 11 organ(s), highest expression level in testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000037338

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 37Ubiquitin-likeInterPro annotationAdd BLAST37
Domaini38 – 112Ubiquitin-likeInterPro annotationAdd BLAST75
Domaini113 – 188Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini189 – 264Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini265 – 340Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini341 – 416Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini417 – 492Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini493 – 568Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini569 – 644Ubiquitin-likeInterPro annotationAdd BLAST76

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0001 Eukaryota
COG5272 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163900

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7DNS3

Identification of Orthologs from Complete Genome Data

More...
OMAi
DKECIPP

Database of Orthologous Groups

More...
OrthoDBi
EOG091G178I

TreeFam database of animal gene trees

More...
TreeFami
TF354256

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019956 Ubiquitin
IPR029071 Ubiquitin-like_domsf
IPR019954 Ubiquitin_CS
IPR000626 Ubiquitin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00240 ubiquitin, 9 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00348 UBIQUITIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00213 UBQ, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54236 SSF54236, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00299 UBIQUITIN_1, 7 hits
PS50053 UBIQUITIN_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F7DNS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DQQRLIFAGK QLEDGTLSDY NIQKESTLHL VLRLRGGMQI FVKTLTGKTI
60 70 80 90 100
TLEVEPSDTI ENVKAKIQDK EGPPDQQRLI FAGKQLEDGR TLSDYNIQKE
110 120 130 140 150
STLHLVLRLR GGMQIFVKTL TGKTITLEVE PSDTIENVKA KIQDKEGIPP
160 170 180 190 200
DQQRLIFAGK QLEDGRTLSD YNIQKESTLH LVLRLRGGMQ IFVKTLTGKT
210 220 230 240 250
ITLEVEPSDT IENVKAKIQD KEGIPPDQQR LIFAGKQLED GRTLSDYNIQ
260 270 280 290 300
KESTLHLVLR LRGGMQIFVK TLTGKTITLE VEPSDTIENV KAKIQDKEGI
310 320 330 340 350
PPDQQRLIFA GKQLEDGRTL SDYNIQKEST LHLVLRLREN MQIFVKTLTG
360 370 380 390 400
KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN
410 420 430 440 450
IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE NVKAKIQDKE
460 470 480 490 500
GIPPDQQRLI FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGMQIFVKTL
510 520 530 540 550
TGKTITLEVE PSDTIENVKA KIQDKEGIPP DQQRLIFAGK QLEDGRTLSD
560 570 580 590 600
YNIQKESTLH LVLRLRGGMQ IFVKTLTGKT ITLEVEPSDT IENVKAKIQD
610 620 630 640
KEGIPPDQQR LIFAGKQLED GRTLSDYNIQ KESTLHLVLR LRGGV
Length:645
Mass (Da):72,703
Last modified:July 27, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD235C7F2052D1FD9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAMC01185333 Genomic DNA No translation available.
AAMC01185334 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSXETT00000037338; ENSXETP00000037338; ENSXETG00000017136

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01185333 Genomic DNA No translation available.
AAMC01185334 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000037338

Proteomic databases

PaxDbiF7DNS3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000037338; ENSXETP00000037338; ENSXETG00000017136

Organism-specific databases

XenbaseiXB-GENE-6066017 ubc

Phylogenomic databases

eggNOGiKOG0001 Eukaryota
COG5272 LUCA
GeneTreeiENSGT00940000163900
InParanoidiF7DNS3
OMAiDKECIPP
OrthoDBiEOG091G178I
TreeFamiTF354256

Enzyme and pathway databases

ReactomeiR-XTR-110312 Translesion synthesis by REV1
R-XTR-110314 Recognition of DNA damage by PCNA-containing replication complex
R-XTR-110320 Translesion Synthesis by POLH
R-XTR-1169091 Activation of NF-kappaB in B cells
R-XTR-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-XTR-1253288 Downregulation of ERBB4 signaling
R-XTR-1295596 Spry regulation of FGF signaling
R-XTR-1358803 Downregulation of ERBB2:ERBB3 signaling
R-XTR-168638 NOD1/2 Signaling Pathway
R-XTR-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-XTR-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-XTR-174113 SCF-beta-TrCP mediated degradation of Emi1
R-XTR-174154 APC/C:Cdc20 mediated degradation of Securin
R-XTR-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-XTR-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-XTR-179409 APC-Cdc20 mediated degradation of Nek2A
R-XTR-182971 EGFR downregulation
R-XTR-187577 SCF(Skp2)-mediated degradation of p27/p21
R-XTR-195253 Degradation of beta-catenin by the destruction complex
R-XTR-201681 TCF dependent signaling in response to WNT
R-XTR-202424 Downstream TCR signaling
R-XTR-209543 p75NTR recruits signalling complexes
R-XTR-209560 NF-kB is activated and signals survival
R-XTR-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-XTR-2173788 Downregulation of TGF-beta receptor signaling
R-XTR-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-XTR-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-XTR-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-XTR-2467813 Separation of Sister Chromatids
R-XTR-2559580 Oxidative Stress Induced Senescence
R-XTR-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-XTR-2559585 Oncogene Induced Senescence
R-XTR-2565942 Regulation of PLK1 Activity at G2/M Transition
R-XTR-2672351 Stimuli-sensing channels
R-XTR-2871837 FCERI mediated NF-kB activation
R-XTR-3134975 Regulation of innate immune responses to cytosolic DNA
R-XTR-3322077 Glycogen synthesis
R-XTR-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-XTR-3769402 Deactivation of the beta-catenin transactivating complex
R-XTR-382556 ABC-family proteins mediated transport
R-XTR-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-XTR-450302 activated TAK1 mediates p38 MAPK activation
R-XTR-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-XTR-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-XTR-4641257 Degradation of AXIN
R-XTR-4641258 Degradation of DVL
R-XTR-4641263 Regulation of FZD by ubiquitination
R-XTR-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-XTR-5357905 Regulation of TNFR1 signaling
R-XTR-5357956 TNFR1-induced NFkappaB signaling pathway
R-XTR-5358346 Hedgehog ligand biogenesis
R-XTR-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-XTR-5607764 CLEC7A (Dectin-1) signaling
R-XTR-5610780 Degradation of GLI1 by the proteasome
R-XTR-5610785 GLI3 is processed to GLI3R by the proteasome
R-XTR-5632684 Hedgehog 'on' state
R-XTR-5654726 Negative regulation of FGFR1 signaling
R-XTR-5654727 Negative regulation of FGFR2 signaling
R-XTR-5654732 Negative regulation of FGFR3 signaling
R-XTR-5654733 Negative regulation of FGFR4 signaling
R-XTR-5655862 Translesion synthesis by POLK
R-XTR-5656121 Translesion synthesis by POLI
R-XTR-5656169 Termination of translesion DNA synthesis
R-XTR-5668541 TNFR2 non-canonical NF-kB pathway
R-XTR-5675221 Negative regulation of MAPK pathway
R-XTR-5675482 Regulation of necroptotic cell death
R-XTR-5676590 NIK-->noncanonical NF-kB signaling
R-XTR-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-XTR-5685942 HDR through Homologous Recombination (HRR)
R-XTR-5687128 MAPK6/MAPK4 signaling
R-XTR-5689603 UCH proteinases
R-XTR-5689877 Josephin domain DUBs
R-XTR-5689880 Ub-specific processing proteases
R-XTR-5689896 Ovarian tumor domain proteases
R-XTR-5689901 Metalloprotease DUBs
R-XTR-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-XTR-5696394 DNA Damage Recognition in GG-NER
R-XTR-5696395 Formation of Incision Complex in GG-NER
R-XTR-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-XTR-5696400 Dual Incision in GG-NER
R-XTR-6781823 Formation of TC-NER Pre-Incision Complex
R-XTR-6782135 Dual incision in TC-NER
R-XTR-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-XTR-6783310 Fanconi Anemia Pathway
R-XTR-6804756 Regulation of TP53 Activity through Phosphorylation
R-XTR-6804757 Regulation of TP53 Degradation
R-XTR-6804760 Regulation of TP53 Activity through Methylation
R-XTR-6807004 Negative regulation of MET activity
R-XTR-68827 CDT1 association with the CDC6:ORC:origin complex
R-XTR-68949 Orc1 removal from chromatin
R-XTR-69017 CDK-mediated phosphorylation and removal of Cdc6
R-XTR-69229 Ubiquitin-dependent degradation of Cyclin D1
R-XTR-69231 Cyclin D associated events in G1
R-XTR-69481 G2/M Checkpoints
R-XTR-69541 Stabilization of p53
R-XTR-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-XTR-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-XTR-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-XTR-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-XTR-8856825 Cargo recognition for clathrin-mediated endocytosis
R-XTR-8856828 Clathrin-mediated endocytosis
R-XTR-8863795 Downregulation of ERBB2 signaling
R-XTR-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-XTR-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-XTR-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-XTR-8939902 Regulation of RUNX2 expression and activity
R-XTR-8941858 Regulation of RUNX3 expression and activity
R-XTR-8948747 Regulation of PTEN localization
R-XTR-8948751 Regulation of PTEN stability and activity
R-XTR-8951664 Neddylation
R-XTR-901032 ER Quality Control Compartment (ERQC)
R-XTR-9010553 Regulation of expression of SLITs and ROBOs
R-XTR-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
R-XTR-9020702 Interleukin-1 signaling
R-XTR-9033241 Peroxisomal protein import
R-XTR-912631 Regulation of signaling by CBL
R-XTR-917729 Endosomal Sorting Complex Required For Transport (ESCRT)
R-XTR-917937 Iron uptake and transport
R-XTR-936440 Negative regulators of DDX58/IFIH1 signaling
R-XTR-937039 IRAK1 recruits IKK complex
R-XTR-937042 IRAK2 mediated activation of TAK1 complex
R-XTR-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-XTR-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-XTR-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-XTR-983168 Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

BgeeiENSXETG00000017136 Expressed in 11 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR019956 Ubiquitin
IPR029071 Ubiquitin-like_domsf
IPR019954 Ubiquitin_CS
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF00240 ubiquitin, 9 hits
PRINTSiPR00348 UBIQUITIN
SMARTiView protein in SMART
SM00213 UBQ, 8 hits
SUPFAMiSSF54236 SSF54236, 9 hits
PROSITEiView protein in PROSITE
PS00299 UBIQUITIN_1, 7 hits
PS50053 UBIQUITIN_2, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7DNS3_XENTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7DNS3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: December 5, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

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