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Protein
Submitted name:

Ubiquitin C

Gene

ubc

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Enzyme and pathway databases

ReactomeiR-XTR-110312 Translesion synthesis by REV1
R-XTR-110314 Recognition of DNA damage by PCNA-containing replication complex
R-XTR-110320 Translesion Synthesis by POLH
R-XTR-1169091 Activation of NF-kappaB in B cells
R-XTR-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-XTR-1253288 Downregulation of ERBB4 signaling
R-XTR-1295596 Spry regulation of FGF signaling
R-XTR-1358803 Downregulation of ERBB2:ERBB3 signaling
R-XTR-168638 NOD1/2 Signaling Pathway
R-XTR-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-XTR-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-XTR-174113 SCF-beta-TrCP mediated degradation of Emi1
R-XTR-174154 APC/C:Cdc20 mediated degradation of Securin
R-XTR-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-XTR-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-XTR-179409 APC-Cdc20 mediated degradation of Nek2A
R-XTR-182971 EGFR downregulation
R-XTR-187577 SCF(Skp2)-mediated degradation of p27/p21
R-XTR-195253 Degradation of beta-catenin by the destruction complex
R-XTR-201681 TCF dependent signaling in response to WNT
R-XTR-202424 Downstream TCR signaling
R-XTR-209543 p75NTR recruits signalling complexes
R-XTR-209560 NF-kB is activated and signals survival
R-XTR-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-XTR-2173788 Downregulation of TGF-beta receptor signaling
R-XTR-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-XTR-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-XTR-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-XTR-2467813 Separation of Sister Chromatids
R-XTR-2559580 Oxidative Stress Induced Senescence
R-XTR-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-XTR-2559585 Oncogene Induced Senescence
R-XTR-2565942 Regulation of PLK1 Activity at G2/M Transition
R-XTR-2672351 Stimuli-sensing channels
R-XTR-2871837 FCERI mediated NF-kB activation
R-XTR-3134975 Regulation of innate immune responses to cytosolic DNA
R-XTR-3322077 Glycogen synthesis
R-XTR-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-XTR-3769402 Deactivation of the beta-catenin transactivating complex
R-XTR-382556 ABC-family proteins mediated transport
R-XTR-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-XTR-450302 activated TAK1 mediates p38 MAPK activation
R-XTR-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-XTR-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-XTR-4641257 Degradation of AXIN
R-XTR-4641258 Degradation of DVL
R-XTR-4641263 Regulation of FZD by ubiquitination
R-XTR-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-XTR-5357905 Regulation of TNFR1 signaling
R-XTR-5357956 TNFR1-induced NFkappaB signaling pathway
R-XTR-5358346 Hedgehog ligand biogenesis
R-XTR-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-XTR-5607764 CLEC7A (Dectin-1) signaling
R-XTR-5610780 Degradation of GLI1 by the proteasome
R-XTR-5610785 GLI3 is processed to GLI3R by the proteasome
R-XTR-5632684 Hedgehog 'on' state
R-XTR-5654726 Negative regulation of FGFR1 signaling
R-XTR-5654727 Negative regulation of FGFR2 signaling
R-XTR-5654732 Negative regulation of FGFR3 signaling
R-XTR-5654733 Negative regulation of FGFR4 signaling
R-XTR-5655862 Translesion synthesis by POLK
R-XTR-5656121 Translesion synthesis by POLI
R-XTR-5656169 Termination of translesion DNA synthesis
R-XTR-5668541 TNFR2 non-canonical NF-kB pathway
R-XTR-5675221 Negative regulation of MAPK pathway
R-XTR-5675482 Regulation of necroptotic cell death
R-XTR-5676590 NIK-->noncanonical NF-kB signaling
R-XTR-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-XTR-5685942 HDR through Homologous Recombination (HRR)
R-XTR-5687128 MAPK6/MAPK4 signaling
R-XTR-5689603 UCH proteinases
R-XTR-5689877 Josephin domain DUBs
R-XTR-5689880 Ub-specific processing proteases
R-XTR-5689896 Ovarian tumor domain proteases
R-XTR-5689901 Metalloprotease DUBs
R-XTR-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-XTR-5696394 DNA Damage Recognition in GG-NER
R-XTR-5696395 Formation of Incision Complex in GG-NER
R-XTR-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-XTR-5696400 Dual Incision in GG-NER
R-XTR-6781823 Formation of TC-NER Pre-Incision Complex
R-XTR-6782135 Dual incision in TC-NER
R-XTR-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-XTR-6783310 Fanconi Anemia Pathway
R-XTR-6804756 Regulation of TP53 Activity through Phosphorylation
R-XTR-6804757 Regulation of TP53 Degradation
R-XTR-6804760 Regulation of TP53 Activity through Methylation
R-XTR-6807004 Negative regulation of MET activity
R-XTR-68827 CDT1 association with the CDC6:ORC:origin complex
R-XTR-68949 Orc1 removal from chromatin
R-XTR-69017 CDK-mediated phosphorylation and removal of Cdc6
R-XTR-69229 Ubiquitin-dependent degradation of Cyclin D1
R-XTR-69231 Cyclin D associated events in G1
R-XTR-69481 G2/M Checkpoints
R-XTR-69541 Stabilization of p53
R-XTR-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-XTR-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-XTR-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-XTR-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-XTR-8856825 Cargo recognition for clathrin-mediated endocytosis
R-XTR-8856828 Clathrin-mediated endocytosis
R-XTR-8863795 Downregulation of ERBB2 signaling
R-XTR-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-XTR-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-XTR-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-XTR-8939902 Regulation of RUNX2 expression and activity
R-XTR-8941858 Regulation of RUNX3 expression and activity
R-XTR-8948747 Regulation of PTEN localization
R-XTR-8948751 Regulation of PTEN stability and activity
R-XTR-8951664 Neddylation
R-XTR-901032 ER Quality Control Compartment (ERQC)
R-XTR-9010553 Regulation of expression of SLITs and ROBOs
R-XTR-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
R-XTR-9020702 Interleukin-1 signaling
R-XTR-9033241 Peroxisomal protein import
R-XTR-912631 Regulation of signaling by CBL
R-XTR-917729 Endosomal Sorting Complex Required For Transport (ESCRT)
R-XTR-917937 Iron uptake and transport
R-XTR-936440 Negative regulators of DDX58/IFIH1 signaling
R-XTR-937039 IRAK1 recruits IKK complex
R-XTR-937042 IRAK2 mediated activation of TAK1 complex
R-XTR-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-XTR-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-XTR-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-XTR-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin CImported
Gene namesi
Name:ubcImported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-6066017 ubc

PTM / Processingi

Proteomic databases

PaxDbiF7DNS3

Expressioni

Gene expression databases

BgeeiENSXETG00000017136 Expressed in 11 organ(s), highest expression level in testis

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000037338

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 37Ubiquitin-likeInterPro annotationAdd BLAST37
Domaini38 – 112Ubiquitin-likeInterPro annotationAdd BLAST75
Domaini113 – 188Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini189 – 264Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini265 – 340Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini341 – 416Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini417 – 492Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini493 – 568Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini569 – 644Ubiquitin-likeInterPro annotationAdd BLAST76

Phylogenomic databases

eggNOGiKOG0001 Eukaryota
COG5272 LUCA
GeneTreeiENSGT00810000125435
InParanoidiF7DNS3
OMAiHLTMQIF
OrthoDBiEOG091G178I
TreeFamiTF354256

Family and domain databases

InterProiView protein in InterPro
IPR019956 Ubiquitin
IPR029071 Ubiquitin-like_domsf
IPR019954 Ubiquitin_CS
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF00240 ubiquitin, 9 hits
PRINTSiPR00348 UBIQUITIN
SMARTiView protein in SMART
SM00213 UBQ, 8 hits
SUPFAMiSSF54236 SSF54236, 9 hits
PROSITEiView protein in PROSITE
PS00299 UBIQUITIN_1, 7 hits
PS50053 UBIQUITIN_2, 9 hits

Sequencei

Sequence statusi: Complete.

F7DNS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DQQRLIFAGK QLEDGTLSDY NIQKESTLHL VLRLRGGMQI FVKTLTGKTI
60 70 80 90 100
TLEVEPSDTI ENVKAKIQDK EGPPDQQRLI FAGKQLEDGR TLSDYNIQKE
110 120 130 140 150
STLHLVLRLR GGMQIFVKTL TGKTITLEVE PSDTIENVKA KIQDKEGIPP
160 170 180 190 200
DQQRLIFAGK QLEDGRTLSD YNIQKESTLH LVLRLRGGMQ IFVKTLTGKT
210 220 230 240 250
ITLEVEPSDT IENVKAKIQD KEGIPPDQQR LIFAGKQLED GRTLSDYNIQ
260 270 280 290 300
KESTLHLVLR LRGGMQIFVK TLTGKTITLE VEPSDTIENV KAKIQDKEGI
310 320 330 340 350
PPDQQRLIFA GKQLEDGRTL SDYNIQKEST LHLVLRLREN MQIFVKTLTG
360 370 380 390 400
KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN
410 420 430 440 450
IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE NVKAKIQDKE
460 470 480 490 500
GIPPDQQRLI FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGMQIFVKTL
510 520 530 540 550
TGKTITLEVE PSDTIENVKA KIQDKEGIPP DQQRLIFAGK QLEDGRTLSD
560 570 580 590 600
YNIQKESTLH LVLRLRGGMQ IFVKTLTGKT ITLEVEPSDT IENVKAKIQD
610 620 630 640
KEGIPPDQQR LIFAGKQLED GRTLSDYNIQ KESTLHLVLR LRGGV
Length:645
Mass (Da):72,703
Last modified:July 27, 2011 - v1
Checksum:iD235C7F2052D1FD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01185333 Genomic DNA No translation available.
AAMC01185334 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSXETT00000037338; ENSXETP00000037338; ENSXETG00000017136

Similar proteinsi

Entry informationi

Entry nameiF7DNS3_XENTR
AccessioniPrimary (citable) accession number: F7DNS3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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