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Entry version 65 (11 Dec 2019)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Myosin heavy chain 13

Gene

MYH13

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationSAAS annotation, Motor protein, MyosinPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Myosin heavy chain 13Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYH13Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:20479 MYH13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F7DEL2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1527 – 1553DisorderedSequence analysisAdd BLAST27
Regioni1911 – 1939DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili846 – 1090Sequence analysisAdd BLAST245
Coiled coili1098 – 1160Sequence analysisAdd BLAST63
Coiled coili1168 – 1195Sequence analysisAdd BLAST28
Coiled coili1197 – 1238Sequence analysisAdd BLAST42
Coiled coili1274 – 1378Sequence analysisAdd BLAST105
Coiled coili1380 – 1442Sequence analysisAdd BLAST63
Coiled coili1612 – 1632Sequence analysisAdd BLAST21
Coiled coili1654 – 1716Sequence analysisAdd BLAST63
Coiled coili1724 – 1765Sequence analysisAdd BLAST42
Coiled coili1773 – 1807Sequence analysisAdd BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0161 Eukaryota
COG5022 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166513

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7DEL2

Database of Orthologous Groups

More...
OrthoDBi
47111at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314375

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14923 MYSc_Myh13, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR042702 Myh13_MYSc
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F7DEL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSDAEMAIF GEAAPYLRKP EKERIEAQNR PFDSKKACFA VDDKELYVKG
60 70 80 90 100
MIQSRENDKV TVKTVDDRTL TLNSDQVFPM NPPKFDKIED MAMMTHLHEP
110 120 130 140 150
AVLFNLKERY AAWMIYTYSG LFCVTVNPYK WLPVYNPEVV TAYRGKKRQE
160 170 180 190 200
APPHIFSISD NAYQFMLTDR DNQSILITGE SGAGKTVNTK RVIQYFATIA
210 220 230 240 250
VTGDKKKEQQ PGKMQGTLED QIIQANPLLE AFGNAKTVRN DNSSRFGKFI
260 270 280 290 300
RIHFGSTGKL ASADIETYLL EKSRVTFQLS SERSYHIFYQ IMSNKKPELI
310 320 330 340 350
DLLLISTNPF DFPFMSQGEV TVASIDDSEE LLATDNAIDI LGFSSEEKVG
360 370 380 390 400
IYKLTGAVMH YGNMKFKQKQ REEQAEPDGT EVADKAGYLM GLNSAEMLKG
410 420 430 440 450
LCCPRVKVGN EYVTKGQNVQ QVTNSVGALA KAVYEKMFLW MVARINQQLD
460 470 480 490 500
TKQPRQYFIG VLDIAGFEIF DFNSLEQLCI NFTNEKLQQF FNHHMFVLEQ
510 520 530 540 550
EEYKKEGIEW EFIDFGMDLA ACIELIEKPM GIFSILEEEC MFPKATDTSF
560 570 580 590 600
KNKLYDQHLG KSSNFQKPKP TKGKAEAHFS LIHYAGTVDY NISGWLDKNK
610 620 630 640 650
DPLNETVVGL YQKSSLKLLS FLFSNYAGAE AGDSGGSKKG GKKKGSSFQT
660 670 680 690 700
VSAVFRENLN KLMTNLRSTH PHFVRCLIPN ETKTPGVMDH HLVLHQLRCN
710 720 730 740 750
GVLEGIRICR KGFPSRILYA DFKQRYRILN ASAIPEGQFI DSKNASEKLL
760 770 780 790 800
NSIDVDREQY RFGHTKVFFK AGLLGLLEEM RDEKLVTLMT RTQALCRGYL
810 820 830 840 850
MRVEFKKMIE RRDSIFCIQY NIRSFMNVKH WPWMNLFFKI KPLLKSAEAE
860 870 880 890 900
REMATMKEDF ERAKEELARS EARRKELEEK MVTLLQEKND LQLQVQSETE
910 920 930 940 950
NLMDAEERCE GLIKSKIQLE AKVKELSERL EEEEEANSEL VAKKRNLEDK
960 970 980 990 1000
CSSLKRDIDD LELTLTKVEK EKHATENKVK NLSEEMTALE GNISKLTKEK
1010 1020 1030 1040 1050
KSLQEAHQQT LDDLQVEEDK VNGLIKINAK LEQQTDDLEG CLEQEKKLRA
1060 1070 1080 1090 1100
DLERVRRKLE GDLKMCQESI MDLENDKQQA EEKLKKKEFE ICQLQTKIDD
1110 1120 1130 1140 1150
EQVLSLQLQK KIKELQARTE ELEEEIEAEH TLRGKIEKQR SDLARELEEI
1160 1170 1180 1190 1200
SERLEEASGA TSAQIEMNKK REAEFQKLRR DLEEATLQHE ATTAALRKKH
1210 1220 1230 1240 1250
TDSVAELGEQ IDNLQRVKQK LEKEKSELKM EIDDMASNME TVSKSKSNIE
1260 1270 1280 1290 1300
RMCRTVEDQF NEIKAKDDQQ TQLIHDLNMQ KARLQTQNGE LSHQMEEKES
1310 1320 1330 1340 1350
LISQLTKSKQ ALTQQLEDLK RQLEEETKAK NALAHALQSS RHDCDLLREQ
1360 1370 1380 1390 1400
YEEEQESKAE LQRALSKANS EVAQWRTKYE TDAIQRMEEL EEAKKKLAQR
1410 1420 1430 1440 1450
LQEAEENTEA VSSKCASLEK TKQRLQGEVD DLMLDLERAH TACTTLDKKQ
1460 1470 1480 1490 1500
RNFDKVLADW KQKLDESKAE LEAAQKESRS LSTELFKMRN AYEEVVDQLE
1510 1520 1530 1540 1550
TLRRENKNLQ EEISDLTEQI AETSKNLQEM EKSKKQVEQE KSDLQAALEE
1560 1570 1580 1590 1600
AEGSLEHEES KILRVQLELS QVKAELDRKV TEKDEEIEQL KRNSQRAAEA
1610 1620 1630 1640 1650
TQSMLDAEIR SRNDALRLKK KMEGDLNEME IQLGHSTRQA GETQKHLRTV
1660 1670 1680 1690 1700
QGQLKDSQLH LDDALRSNED LKEQLAIVER RNGLLLEELE EMKVALEQTE
1710 1720 1730 1740 1750
RTRRLSEQEL LDASDRVQLL HSQNTSLINT NKKLEADIAQ CQAEMENSIQ
1760 1770 1780 1790 1800
ESRNAEEKAK KAITDVAMMA EELKKEQDTS AHLERMKKNL EQTVKDLQHR
1810 1820 1830 1840 1850
LDEAEQLALK GGKKQIQKLE NRVRELENEL DAEQKRGAEA LKGAHKYERK
1860 1870 1880 1890 1900
VKEMTYQVEE DRKNILRLQD LVDKLQAKVK AYKRQAEEAE EQANMQLSRC
1910 1920 1930
RRVQHKLEEA EERADIAESQ VNKLRAKSRD VGGQISELE
Length:1,939
Mass (Da):223,600
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i918AAB9A99528C37
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F5PLL8A0A5F5PLL8_HORSE
Myosin heavy chain 13
MYH13
1,938Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000020847; ENSECAP00000017137; ENSECAG00000019568

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF7DEL2

Genome annotation databases

EnsembliENSECAT00000020847; ENSECAP00000017137; ENSECAG00000019568

Organism-specific databases

VGNCiVGNC:20479 MYH13

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000166513
InParanoidiF7DEL2
OrthoDBi47111at2759
TreeFamiTF314375

Family and domain databases

CDDicd14923 MYSc_Myh13, 1 hit
Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR042702 Myh13_MYSc
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7DEL2_HORSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7DEL2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: December 11, 2019
This is version 65 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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