UniProtKB - F7DCH4 (F7DCH4_HORSE)
Protein
Calponin
Gene
CNN3
Organism
Equus caballus (Horse)
Status
Functioni
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.UniRule annotation
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
GO - Biological processi
- actomyosin structure organization Source: InterPro
Keywordsi
Molecular function | Actin-bindingUniRule annotation, Calmodulin-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: CalponinUniRule annotation |
Gene namesi | Name:CNN3Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:16672, CNN3 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000020188, Expressed in embryo and 23 other tissues |
ExpressionAtlasi | F7DCH4, baseline |
Interactioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 130 | Calponin-homology (CH)InterPro annotationAdd BLAST | 105 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 280 – 329 | DisorderedSequence analysisAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 281 – 298 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 302 – 318 | PolyampholyteSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000154539 |
HOGENOMi | CLU_055232_0_1_1 |
InParanoidi | F7DCH4 |
OMAi | QDDYPRE |
OrthoDBi | 861989at2759 |
TreeFami | TF313921 |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001997, Calponin/LIMCH1 IPR000557, Calponin_repeat IPR001715, CH-domain IPR036872, CH_dom_sf IPR003096, SM22_calponin |
Pfami | View protein in Pfam PF00402, Calponin, 3 hits PF00307, CH, 1 hit |
PRINTSi | PR00889, CALPONIN PR00888, SM22CALPONIN |
SMARTi | View protein in SMART SM00033, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS01052, CALPONIN_1, 2 hits PS51122, CALPONIN_2, 3 hits PS50021, CH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F7DCH4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTHFNKGPSY GLSAEVKNKI ASKYDHQAEE DLRNWIEEVT GMSIGTNFQL
60 70 80 90 100
GLKDGIILCE LINKLQPGSV KKVNESSLNW PQLENIGNFI KAIQAYGMKP
110 120 130 140 150
HDIFEANDLF ENGNMTQVQT TLVALAGLAK TKGFHTTIDV GVKYAEKQTR
160 170 180 190 200
RFDEGKLKAG QSVIGLQMGT NKCASQAGMT AYGTRRHLYD PKMQTDKPFD
210 220 230 240 250
QTTISLQMGT NKGASQAGML APGTRRDIYD QKLTLQPVDN STISLQMGTN
260 270 280 290 300
KVASQKGMSV YGLGRQVYDP KYCAAPTEPV IHNGSQGTGT NGSEISDSDY
310 320
QAEYPDEYHG EYQDDYPRDY QYGDQGIDY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2I3T1 | A0A3Q2I3T1_HORSE | Calponin | CNN3 | 283 | Annotation score: |
Sequence databases
RefSeqi | XP_001490877.1, XM_001490827.5 |
Genome annotation databases
Ensembli | ENSECAT00000021552; ENSECAP00000017757; ENSECAG00000020188 |
GeneIDi | 100058159 |
KEGGi | ecb:100058159 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_001490877.1, XM_001490827.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F7DCH4 |
PRIDEi | F7DCH4 |
Genome annotation databases
Ensembli | ENSECAT00000021552; ENSECAP00000017757; ENSECAG00000020188 |
GeneIDi | 100058159 |
KEGGi | ecb:100058159 |
Organism-specific databases
CTDi | 1266 |
VGNCi | VGNC:16672, CNN3 |
Phylogenomic databases
GeneTreei | ENSGT00940000154539 |
HOGENOMi | CLU_055232_0_1_1 |
InParanoidi | F7DCH4 |
OMAi | QDDYPRE |
OrthoDBi | 861989at2759 |
TreeFami | TF313921 |
Gene expression databases
Bgeei | ENSECAG00000020188, Expressed in embryo and 23 other tissues |
ExpressionAtlasi | F7DCH4, baseline |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001997, Calponin/LIMCH1 IPR000557, Calponin_repeat IPR001715, CH-domain IPR036872, CH_dom_sf IPR003096, SM22_calponin |
Pfami | View protein in Pfam PF00402, Calponin, 3 hits PF00307, CH, 1 hit |
PRINTSi | PR00889, CALPONIN PR00888, SM22CALPONIN |
SMARTi | View protein in SMART SM00033, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS01052, CALPONIN_1, 2 hits PS51122, CALPONIN_2, 3 hits PS50021, CH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7DCH4_HORSE | |
Accessioni | F7DCH4Primary (citable) accession number: F7DCH4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 10, 2021 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |