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Protein
Submitted name:

Hyperpolarization activated cyclic nucleotide gated potassium channel 3

Gene

HCN3

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Hyperpolarization activated cyclic nucleotide gated potassium channel 3Imported
Gene namesi
Name:HCN3Imported
OrganismiEquus caballus (Horse)Imported
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:18712 HCN3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei96 – 120HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSECAG00000019972 Expressed in 3 organ(s), highest expression level in prefrontal cortex
ExpressionAtlasiF7D898 baseline

Structurei

3D structure databases

ProteinModelPortaliF7D898
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini430 – 536Cyclic nucleotide-bindingInterPro annotationAdd BLAST107

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0498 Eukaryota
ENOG410XPSE LUCA
GeneTreeiENSGT00900000140801
KOiK04956
OMAiVMEQHLV

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR013621 Ion_trans_N
IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00520 Ion_trans, 1 hit
PF08412 Ion_trans_N, 1 hit
PRINTSiPR01463 EAGCHANLFMLY
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F7D898-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAEQRPTSP AGDGATPGLE AAPPAAPASA TAASGPTPGS GSGPEPKRRQ
60 70 80 90 100
LGTLLQPTVN KFSLRVFGSH KAVEIEQERV KSAGAWIIHP YSDFRFYWDL
110 120 130 140 150
IMLLLMVGNL IVLPVGITFF KEENSPPWIV FNVLSDTFFL LDLVLNFRTG
160 170 180 190 200
IVVEEGAEIL LAPRAIRTRY LRTWFLVDLI SSIPVDYIFL VVELEPRLDA
210 220 230 240 250
EVYKTARALR IVRFTKILSL LRLLRLSRLI RYIHQWEEIF HMTYDLASAV
260 270 280 290 300
VRIFNLIGMM LLLCHWDGCL QFLVPMLQDF PPDCWVSINH MVNHSWGRQY
310 320 330 340 350
SHALFKAMSH MLCIGYGQQA PVGMPDVWLT MLSMIVGATC YAMFIGHATA
360 370 380 390 400
LIQSLDSSRR QYQEKYKQVE QYMSFHKLPA DTRQRIHEYY EHRYQGKMFD
410 420 430 440 450
EESILGELSE PLREEIINFT CRGLVAHMPL FAHADPSFVT AVLTKLRFEV
460 470 480 490 500
FQPGDLVVRE GSVGRKMYFI QHGLLSVLAR GARDTRLTDG SYFGEICLLT
510 520 530 540 550
RGRRTASVRA DTYCRLYSLS VDHFNAVLEE FPMMRRAFET VAMDRLRRIG
560 570 580 590 600
KKNSILQRKR SEPSPGSSGG IMEQHLVQHD RDMARGVRGL APGTGARLSG
610 620 630 640 650
KPVLWEPLVH APLQAAAVTS NVAIALTHQR SPLPLSPDSP ATFLARSARR
660 670 680 690 700
SAGSPASPLV PVRAGPLLAR GPWASTSRLP APPARTLHAS LSRAGRSQVS
710 720 730 740 750
LLGPPPGGGG RRLGPRGRPL SASQPSLPQR AAGDGSPGRK GSGSERLPPS
760 770 780
GLLAKPPGTA QPPRPPVPEP VTPRGPQLSA NM
Length:782
Mass (Da):86,556
Last modified:July 27, 2011 - v1
Checksum:i3D22E0A630E92A54
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6T124F6T124_HORSE
Hyperpolarization activated cyclic ...
HCN3
873Annotation score:

Sequence databases

RefSeqiXP_001498862.1, XM_001498812.3

Genome annotation databases

EnsembliENSECAT00000021238; ENSECAP00000017483; ENSECAG00000019972
GeneIDi100063574
KEGGiecb:100063574

Cross-referencesi

Sequence databases

RefSeqiXP_001498862.1, XM_001498812.3

3D structure databases

ProteinModelPortaliF7D898
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000021238; ENSECAP00000017483; ENSECAG00000019972
GeneIDi100063574
KEGGiecb:100063574

Organism-specific databases

CTDi57657
VGNCiVGNC:18712 HCN3

Phylogenomic databases

eggNOGiKOG0498 Eukaryota
ENOG410XPSE LUCA
GeneTreeiENSGT00900000140801
KOiK04956
OMAiVMEQHLV

Gene expression databases

BgeeiENSECAG00000019972 Expressed in 3 organ(s), highest expression level in prefrontal cortex
ExpressionAtlasiF7D898 baseline

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR013621 Ion_trans_N
IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00520 Ion_trans, 1 hit
PF08412 Ion_trans_N, 1 hit
PRINTSiPR01463 EAGCHANLFMLY
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF7D898_HORSE
AccessioniPrimary (citable) accession number: F7D898
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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