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Entry version 40 (07 Apr 2021)
Sequence version 2 (11 Dec 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

THSD7B

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THSD7BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri13616 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002280 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1560 – 1583HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMODG00000001131, Expressed in skeletal muscle tissue and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
13616.ENSMODP00000001348

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini184 – 232TSP1_spondinInterPro annotationAdd BLAST49
Domaini341 – 394TSP1_spondinInterPro annotationAdd BLAST54
Domaini606 – 664TSP1_spondinInterPro annotationAdd BLAST59
Domaini1254 – 1307TSP1_spondinInterPro annotationAdd BLAST54
Domaini1376 – 1435TSP1_spondinInterPro annotationAdd BLAST60

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3538, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159262

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004819_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7D4Z3

Identification of Orthologs from Complete Genome Data

More...
OMAi
PCKINNE

TreeFam database of animal gene trees

More...
TreeFami
TF329791

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 12 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR044004, TSP1_spondin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF19028, TSP1_spondin, 5 hits
PF00090, TSP_1, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209, TSP1, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895, SSF82895, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50092, TSP1, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

F7D4Z3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LDWKSGRLGN ALIINGIFVL QMYKLNSSFS LNQSLGRYIN DVHLCFFNPL
60 70 80 90 100
GPWGRCTGNC GPGGIQSRGV WCFHLEGWTS LLSNCEEADK PENERSCFRV
110 120 130 140 150
CDWHGELFEW EVSEWQICVL APFIHGEVKL RTSECVTAQH GLQHRTVHCI
160 170 180 190 200
QKLNRTVVIS EICEYFAPQP PTEQACLIPC PRDCVVSEFS PWSVCSQGCG
210 220 230 240 250
KKLQHRTRSI ISPPLYGGLM CPNLTESRAC DSYIPCPLGE EEYMFSLKVG
260 270 280 290 300
PWSKCKLPHL KEVSLSGRTI VDFSSDSKER VTFKHQGYKP HHHSKPWDIE
310 320 330 340 350
IGYQTRQVRC SRSDGKNAML SLCMQDNFPL TFQSCVMPKD CETSDWSSWS
360 370 380 390 400
YCSKTCQSGD LSPGFRSRSR NVKHIAIGGG QECPELQEKE ACNLGGELLQ
410 420 430 440 450
LCSRYSWKTS EWKECQVTLL LEQQDPHWHT TGSLCGGGIQ TRELYCAQST
460 470 480 490 500
TESSGQRLKE ASRPVDKKLC PGPAPATSRI CNVPCSTDCM VSSWSAWGLC
510 520 530 540 550
VHENCQDPQG KKGFRLRQRH ILMESTGPDG NCPHLVESLP CDDPMCYQWL
560 570 580 590 600
VSEGVCIPDH GKCGLGHHIL KAVCQNDRGE EVSGNLCLAP PPPERMACEI
610 620 630 640 650
PCRMDCVVSQ WASWSACSQS CSNKNTGGKQ TRTRTILALP GDGGKPCPPP
660 670 680 690 700
QALQEYRLCN DHSCTHFYWE TSPWGSCSED ALVTALNATS NWSGEATCGV
710 720 730 740 750
GIQTRKVFCM KSHMGQAMIK RCPDSTRPET VRPCLLPCKR DCIVTPFSEW
760 770 780 790 800
TPCPTSCQQE NGTLIKQSRY RIVIQEAANG GQECPDTLFE ERECEDITYC
810 820 830 840 850
PVYRWKAHKW NSCILVPESV RQGMMGTSEA CGKGLQTRDI TCLSDDNQSA
860 870 880 890 900
EMIDCLKWAG DMPPLVQECH VACRDDCMFT PWSKFTPCST DCDTVRTRRR
910 920 930 940 950
QLTGKSRKKE KCQNAEIYPL VETEACPCEA FTSQPHGNWS ECILPESKKE
960 970 980 990 1000
AQRGLRLRGD AKTCGKGVRL QAIVCSDKNG RLVDPSYCSS SGYIEEECFI
1010 1020 1030 1040 1050
PCPFDCKLSD WSNWGSCSSS CGIGVRIRSK WLKEKPYNGG RPCPKLDLKN
1060 1070 1080 1090 1100
QVHEAVPCYS ECNQYSWVVE HWSPCRINSE LRAFRCGEGI QTRKVRCVNT
1110 1120 1130 1140 1150
MDDSESGSVD SALCNQAEIP AEAQACSLLC PNECVMSEWG QWSKCPQSCD
1160 1170 1180 1190 1200
PHSMQRRSRY LLRPPLSSRT CAEDSQVQPC ILNENCFQYH YNITEWSMCQ
1210 1220 1230 1240 1250
LSENATCGQG VKTRLLSCVR SDGKSVSMNY CEQQNLERPV KMSLRCLVEC
1260 1270 1280 1290 1300
AVNCQLSEWT SWSECSQTCG HGGRRSRTRF IIIPAQGEGR PCPVQLTQQK
1310 1320 1330 1340 1350
TCPVKPCYSW VMGTWSSCIL EVDCGDGVQV RNLSCVVHNA SASPTAKQVE
1360 1370 1380 1390 1400
NTLCGEWLPQ ESVLQLPCSV PCPGDCHLTE WSEWSTCELT CIDGRSFESM
1410 1420 1430 1440 1450
GRQSRSRTFV IQSFENQDNC PEQVLETRPC TGGKCYHYTW KASLWRDNER
1460 1470 1480 1490 1500
TVWCQRSDGI NVTGGCSAQS RPASIRQCNP ACRKPFSYCT QVICGCEKGY
1510 1520 1530 1540 1550
TEIMRSDGFL DYCVKIPGSE DKKADVKNIA AKNRPVNSKI HDIFKGWSLQ
1560 1570 1580 1590 1600
PLDPDGRVKL WVYGVSAGGF LLLIFLIFTS YLCPRQPLKR TNFRPSVLIE
1610 1620
FSKMKFPVPI KSQNWPKVPY
Length:1,620
Mass (Da):181,854
Last modified:December 11, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED42B27C1890A2E8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F8GU03A0A5F8GU03_MONDO
Uncharacterized protein
THSD7B
1,591Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8HCW0A0A5F8HCW0_MONDO
Uncharacterized protein
THSD7B
1,578Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8HEH4A0A5F8HEH4_MONDO
Uncharacterized protein
THSD7B
1,603Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8H6P6A0A5F8H6P6_MONDO
Uncharacterized protein
THSD7B
1,579Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8GNH7A0A5F8GNH7_MONDO
Uncharacterized protein
THSD7B
1,593Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8G7T5A0A5F8G7T5_MONDO
Uncharacterized protein
THSD7B
1,089Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMODT00000001376; ENSMODP00000001348; ENSMODG00000001131

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi13616.ENSMODP00000001348

Genome annotation databases

EnsembliENSMODT00000001376; ENSMODP00000001348; ENSMODG00000001131

Phylogenomic databases

eggNOGiKOG3538, Eukaryota
GeneTreeiENSGT00940000159262
HOGENOMiCLU_004819_0_0_1
InParanoidiF7D4Z3
OMAiPCKINNE
TreeFamiTF329791

Gene expression databases

BgeeiENSMODG00000001131, Expressed in skeletal muscle tissue and 14 other tissues

Family and domain databases

Gene3Di2.20.100.10, 12 hits
InterProiView protein in InterPro
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR044004, TSP1_spondin_dom
PfamiView protein in Pfam
PF19028, TSP1_spondin, 5 hits
PF00090, TSP_1, 4 hits
SMARTiView protein in SMART
SM00209, TSP1, 15 hits
SUPFAMiSSF82895, SSF82895, 12 hits
PROSITEiView protein in PROSITE
PS50092, TSP1, 14 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7D4Z3_MONDO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7D4Z3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: April 7, 2021
This is version 40 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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