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Entry version 57 (31 Jul 2019)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

ADAM metallopeptidase with thrombospondin type 1 motif 14

Gene

ADAMTS14

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M12.024

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ADAM metallopeptidase with thrombospondin type 1 motif 14Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADAMTS14Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:15063 ADAMTS14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F7D1G5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000014713 Expressed in 2 organ(s), highest expression level in liver

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini504 – 708Peptidase M12BInterPro annotationAdd BLAST205
Domaini1307 – 1345PLACInterPro annotationAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni26 – 150DisorderedSequence analysisAdd BLAST125
Regioni173 – 242DisorderedSequence analysisAdd BLAST70
Regioni1349 – 1471DisorderedSequence analysisAdd BLAST123

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi29 – 45PolarSequence analysisAdd BLAST17
Compositional biasi102 – 139Pro-richSequence analysisAdd BLAST38
Compositional biasi199 – 214PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1354 – 1379Pro-richSequence analysisAdd BLAST26
Compositional biasi1398 – 1434PolarSequence analysisAdd BLAST37

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3538 Eukaryota
ENOG410XPKZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158426

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7D1G5

Identification of Orthologs from Complete Genome Data

More...
OMAi
TAMGLEW

TreeFam database of animal gene trees

More...
TreeFami
TF313537

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 4 hits
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041645 ADAM_CR_2
IPR010294 ADAM_spacer1
IPR013273 ADAMTS/ADAMTS-like
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17771 ADAM_CR_2, 1 hit
PF05986 ADAM_spacer1, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01857 ADAMTSFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209 TSP1, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895 SSF82895, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50900 PLAC, 1 hit
PS50092 TSP1, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F7D1G5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGSKESKVS GGIKTVMKER RRCSLSRWGA HSFPTQMQSD ISSARGSGEP
60 70 80 90 100
ALRLSKGGGE AQGKRLPAVT AGEPRRLRGH APRTPGAPAL VPRGTSDPAR
110 120 130 140 150
PRTPQPSAPP PGRTAPPAPT PPRPARVPTQ GPPHHPLARL RPRPGASRLG
160 170 180 190 200
RAEWPAVGTG ALARWPLRSP AGSLGCPEPA VQPAAPRGGP GAGGQEAARR
210 220 230 240 250
EEASAEKAET GRPAREQPQA RPSLARSVGL GARTPARPAS PRGHMAPLGA
260 270 280 290 300
LLSCLLPLHC ALCAAAGSRT PELHLSGKLG DYDVTVPCST DFRGRFLSHV
310 320 330 340 350
VSGPAAASAG SAIVDRPPAP LSHSSHFRVA RSPRRPEGAT LRPGWAGRPS
360 370 380 390 400
LYFNVTIFGD KLHLHLQPNQ RLVVPGASVQ WQEDFQELFR QPLRRECVYT
410 420 430 440 450
GGVTGMPGAA VAISNCDGLA GLIRTDSTDF FIEPLEWGQQ EKEASGRTHV
460 470 480 490 500
VYRREVVPRE WAEPGGDLHN EAFGLGSLPN LLGLVGDQLG DGDRKRRHAK
510 520 530 540 550
TGSYSIEVLL AVDDSVVRFH GKEHVQNYVL TLMNIVDEIY HDESLGAHIN
560 570 580 590 600
IALVRLIMVG YRQSLSLIER GNPSRSLEQV CRWAHSQQRQ DPDHAEHHDH
610 620 630 640 650
VIFLTRQDFG PSGMPGYAPV TGMCHPLRSC ALNHEDGFSS AFVVAHETGH
660 670 680 690 700
VLGMEHDGQG NGCADETSLG SVMAPLVQAA FHRFHWSRCS KLELSRYLPS
710 720 730 740 750
YDCLLDDPFV PAWPRPPELP GIDYSMDEQC RFDFGTGYHT CSVFRTFEPC
760 770 780 790 800
KQLWCSHPDN PYFCKTKKGP PLDGTECEPG KWCFKGHCIW KSLEQTYGQD
810 820 830 840 850
GGWSSWTTFG SCSRSCGGGV RSRSRSCDNP PPAYGGRLCS GPTFQYQICN
860 870 880 890 900
SEECPGPYED FRAQQCAKRN SYYIHQNAKH SWVPYEPDDD AQKCELICQS
910 920 930 940 950
EDTGAVVFMN QVVHDGTRCS YRDPYSICAR GECVPVGCDK EVGSMKADDK
960 970 980 990 1000
CGVCGGDNSH CRTVKGTLGK ASKQAGALKL VQIPAGARHI QIEELEKAPH
1010 1020 1030 1040 1050
RIAVKNQVTG SFILNPKGKE AASQTFMAMG LEWEYAVEDA KESLRTSGPL
1060 1070 1080 1090 1100
PEAIAVLVLP SAEGGPRSTL AYKYIIHEDL LPLIGSNNVL LEETDTYEWA
1110 1120 1130 1140 1150
LKSWAPCTKA CGGGIQFTKY GCRRRRDHHM VQRHLCDHRK RPKPIRRRCN
1160 1170 1180 1190 1200
QHPCAPPAWV TEEWGTCSRS CGKLGVQTRG VQCLLPLSNG THKAMPAKAC
1210 1220 1230 1240 1250
PGDRPEARRP CFRVPCPAQW RTGAWSQCSA TCGEGIQQRQ VVCRTSANSL
1260 1270 1280 1290 1300
GQCEGDKPDT VQICSLPACG GNLWNSTVRA DVPELVTPEG QWVPQPGPLH
1310 1320 1330 1340 1350
PINKISSTEP CVGDRSIFCQ MEVLDRYCFI PGYHRLCCES CTKKALGPGV
1360 1370 1380 1390 1400
SPAPALASPS PFSAPGSPLP GPKAPPDAVE PTVGPTGSED HQHGRPTQLP
1410 1420 1430 1440 1450
GPLSTSSRVT QRPFAPQKLS PRTFWGTSPC THRGLTWGWT GAPLQASENK
1460 1470
GQLREDPKYP GTSLPATSPV T
Length:1,471
Mass (Da):159,566
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA79A978C872A7930
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000016035; ENSECAP00000012935; ENSECAG00000014713

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiM12.024

Proteomic databases

PaxDbiF7D1G5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000016035; ENSECAP00000012935; ENSECAG00000014713

Organism-specific databases

VGNCiVGNC:15063 ADAMTS14

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
ENOG410XPKZ LUCA
GeneTreeiENSGT00940000158426
InParanoidiF7D1G5
OMAiTAMGLEW
TreeFamiTF313537

Gene expression databases

BgeeiENSECAG00000014713 Expressed in 2 organ(s), highest expression level in liver

Family and domain databases

Gene3Di2.20.100.10, 4 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR041645 ADAM_CR_2
IPR010294 ADAM_spacer1
IPR013273 ADAMTS/ADAMTS-like
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF17771 ADAM_CR_2, 1 hit
PF05986 ADAM_spacer1, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 3 hits
PRINTSiPR01857 ADAMTSFAMILY
SMARTiView protein in SMART
SM00209 TSP1, 4 hits
SUPFAMiSSF82895 SSF82895, 4 hits
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50900 PLAC, 1 hit
PS50092 TSP1, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7D1G5_HORSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7D1G5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: July 31, 2019
This is version 57 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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