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Protein
Submitted name:

Beta-secretase 1 isoform B preproprotein

Gene

BACE1

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93PROSITE-ProRule annotation1
Active sitei264PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl proteasePROSITE-ProRule annotationSAAS annotation, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.004

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-secretase 1 isoform B preproproteinImported
Submitted name:
Beta-secretase 1 precursorImported
Gene namesi
Name:BACE1Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501409073522 – 476Sequence analysisAdd BLAST455

Expressioni

Gene expression databases

BgeeiENSMMUG00000007785
ExpressionAtlasiF7CQI1 baseline

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000010231

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 391Peptidase A1InterPro annotationAdd BLAST317

Sequence similaritiesi

Belongs to the peptidase A1 family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
GeneTreeiENSGT00910000144168
OrthoDBiEOG091G0CNK
TreeFamiTF329595

Family and domain databases

CDDicd05473 beta_secretase_like, 1 hit
Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR009119 BACE
IPR009120 BACE1
IPR033874 Memapsin-like
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 2 hits
PTHR13683:SF245 PTHR13683:SF245, 2 hits
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR01816 BACE1
PR01815 BACEFAMILY
PR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 1 hit
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

F7CQI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQALPWLLL WMGAGVLPAH GTQHGIRLPL RSGLGGAPVG LRLPRETDEE
60 70 80 90 100
PEEPGRRGSF VEMVDNLRGK SGQGYYVEMT VGSPPQTLNI LVDTGSSNFA
110 120 130 140 150
VGAAPHPFLH RYYQRQLSST YRDLRKGVYV PYTQGKWEGE LGTDLVSIPH
160 170 180 190 200
GPNVTVRANI AAITESDKFF INGSNWEGIL GLAYAEIARL CGAGFPLNQS
210 220 230 240 250
EVLASVGGSM IIGGIDHSLY TGSLWYTPIR REWYYEVIIV RVEINGQDLK
260 270 280 290 300
MDCKEYNYDK SIVDSGTTNL RLPKKVFEAA VKSIKAASST EKFPDGFWLG
310 320 330 340 350
EQLVCWQAGT TPWNIFPVIS LYLMGEVTNQ SFRITILPQQ YLRPVEDVAT
360 370 380 390 400
SQDDCYKFAI SQSSTGTVMG AVIMEGFYVV FDRARKRIGF AVSACHVHDE
410 420 430 440 450
FRTAAVEGPF VTPDMEDCGY NIPQTDESTL MTIAYVMAAI CALFMLPLCL
460 470
MVCQWRCLRC LRQQHDDFAD DISLLK
Length:476
Mass (Da):52,878
Last modified:November 30, 2016 - v2
Checksum:i8881C4DC14B783A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03013486 Genomic DNA No translation available.
JSUE03013487 Genomic DNA No translation available.
JSUE03013488 Genomic DNA No translation available.
JU319948 mRNA Translation: AFE63704.1
RefSeqiXP_014971192.1, XM_015115706.1
UniGeneiMmu.3022

Genome annotation databases

EnsembliENSMMUT00000010905; ENSMMUP00000010231; ENSMMUG00000007785
GeneIDi697694

Similar proteinsi

Entry informationi

Entry nameiF7CQI1_MACMU
AccessioniPrimary (citable) accession number: F7CQI1
Secondary accession number(s): H9EMU5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: November 30, 2016
Last modified: May 23, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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