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Entry version 54 (12 Aug 2020)
Sequence version 2 (11 Dec 2019)
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Protein
Submitted name:

AT-rich interaction domain 2

Gene

pcdh7

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation
LigandCalciumARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-3214858, RMTs methylate histone arginines
R-XTR-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AT-rich interaction domain 2Imported
Submitted name:
Protocadherin 7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pcdh7Imported
Synonyms:arid2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-6070950, arid2
XB-GENE-1007357, pcdh7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei849 – 872HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_502392136825 – 1042Sequence analysisAdd BLAST1018

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F7CPG2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSXETG00000014656, Expressed in gastrula and 11 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000032105

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 137CAInterPro annotationAdd BLAST94
Domaini161 – 277CAInterPro annotationAdd BLAST117
Domaini301 – 384CAInterPro annotationAdd BLAST84
Domaini416 – 504CAInterPro annotationAdd BLAST89
Domaini528 – 608CAInterPro annotationAdd BLAST81
Domaini632 – 711CAInterPro annotationAdd BLAST80
Domaini737 – 818CAInterPro annotationAdd BLAST82

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni882 – 950DisorderedSequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi882 – 902PolyampholyteSequence analysisAdd BLAST21
Compositional biasi916 – 950PolarSequence analysisAdd BLAST35

Keywords - Domaini

RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2312, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016138

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003714_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7CPG2

KEGG Orthology (KO)

More...
KOi
K16498

TreeFam database of animal gene trees

More...
TreeFami
TF106406

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013164, Cadherin_N
IPR013585, Protocadherin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028, Cadherin, 6 hits
PF08266, Cadherin_2, 1 hit
PF08374, Protocadherin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205, CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112, CA, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313, SSF49313, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232, CADHERIN_1, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F7CPG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTEGVPSCW SSWLLLLQIS LALAATKQLL KYRIAEEGPA DVRIGNVAKE
60 70 80 90 100
IGIVKGSGDV TFSLESGSDY FKIDNVTGEL STTERRIDRE KLPQCQMIFD
110 120 130 140 150
ENECFIDFEV SVIGPAQSWV ELFEGRVVIL DINDNTPTFP SPVLTLTVEE
160 170 180 190 200
NRPVGTLYLL PTATDRDFGR NGIERYELIQ DAGESLYVSG RRGAAESSLY
210 220 230 240 250
PGKRRMESDS RSSVFELQVA DTSDGEKQPQ LIVKGPLDRE QRDSYELTLR
260 270 280 290 300
VRDGGEPPRS SQSILRVLIT DVNDNNPRFE KSVYEADLAE NSAPGTPILQ
310 320 330 340 350
LRATDYDVGV NGQIEYVFGA ATESVRRLLR LDENSGWLSV LHRIDREEVN
360 370 380 390 400
QLRFTVMARD RGQPPKTDKA TVVLNIKDEN DNVPLIDIRK IGRIPVKDGM
410 420 430 440 450
ANVAEDVLVD TPIALVQVSD RDQGENGVVT CTVVGDVPFQ LKPANDGEGE
460 470 480 490 500
QNKKKYFLHT SAPLDYENVK EYNVIIVAVD SGSPSLSSNN SLIVKVGDTN
510 520 530 540 550
DNPPVFSQAV VEVAFPENNV LGERVATVLA TDADSGKNAE IAYSLEPSME
560 570 580 590 600
GIFSIHPDTG DITVNIILDR EQTDRYEFKV IAKDKGIPVL QGTTSVVVQV
610 620 630 640 650
ADRNDNEPRF MQDVFTFYVK ENLQPNSPVG MVTVMDADKG RNAEMSLFIE
660 670 680 690 700
EDSDIFSIEN DTGTIYSTVS FDREHQTSYT FKVKAVDGGD PPRSATATVS
710 720 730 740 750
LFVMDENDNA PTISFPINSS YAVLSPSSNV RTVVASVVAT DSDNGVNADL
760 770 780 790 800
NYSIVGGNPY KLFEIDSTSG VVSLVGKLTS KHYGLHRLVV QVNDSGQPPQ
810 820 830 840 850
STIALVHVFV NETISNATVV DYQIARSLHT PLTQDIAGDP SYDMSKQRLS
860 870 880 890 900
IVIGVVAGIM TVILIILVVV MARYCRAKSK NGYEAGKKDH EDFFTPQQHD
910 920 930 940 950
KNKKPKKDKK NKKSKQPLYS SIVTVEASKP NGQRYDSVNE KLSDSPSMGR
960 970 980 990 1000
YRTVNGGPGS PDLARHYKSS SPLPTVQLHP QSPTAGKKHQ AVQDLPPANT
1010 1020 1030 1040
FVGAGDNISI GSDHCSEYSC QTNNKYSKQV TAHPSCDPQL RS
Length:1,042
Mass (Da):114,453
Last modified:December 11, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i810C12805413C753
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_001128292.2, NM_001134820.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSXETT00000032105; ENSXETP00000032105; ENSXETG00000014656
ENSXETT00000071851; ENSXETP00000080090; ENSXETG00000022281

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100124985

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:100124985

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001128292.2, NM_001134820.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000032105

Proteomic databases

PaxDbiF7CPG2

Genome annotation databases

EnsembliENSXETT00000032105; ENSXETP00000032105; ENSXETG00000014656
ENSXETT00000071851; ENSXETP00000080090; ENSXETG00000022281
GeneIDi100124985
KEGGixtr:100124985

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5099
XenbaseiXB-GENE-6070950, arid2
XB-GENE-1007357, pcdh7

Phylogenomic databases

eggNOGiKOG2312, Eukaryota
GeneTreeiENSGT00390000016138
HOGENOMiCLU_003714_0_0_1
InParanoidiF7CPG2
KOiK16498
TreeFamiTF106406

Enzyme and pathway databases

ReactomeiR-XTR-3214858, RMTs methylate histone arginines
R-XTR-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Gene expression databases

BgeeiENSXETG00000014656, Expressed in gastrula and 11 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013164, Cadherin_N
IPR013585, Protocadherin
PfamiView protein in Pfam
PF00028, Cadherin, 6 hits
PF08266, Cadherin_2, 1 hit
PF08374, Protocadherin, 1 hit
PRINTSiPR00205, CADHERIN
SMARTiView protein in SMART
SM00112, CA, 7 hits
SUPFAMiSSF49313, SSF49313, 7 hits
PROSITEiView protein in PROSITE
PS00232, CADHERIN_1, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7CPG2_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7CPG2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: August 12, 2020
This is version 54 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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