UniProtKB - F7CM75 (F7CM75_HORSE)
Protein
Structural maintenance of chromosomes protein
Gene
SMC1A
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: InterPro
- chromatin binding Source: InterPro
GO - Biological processi
- DNA repair Source: InterPro
- meiotic cell cycle Source: UniProtKB-KW
- mitotic sister chromatid cohesion Source: InterPro
Keywordsi
Biological process | Cell cycleARBA annotation, MeiosisARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Structural maintenance of chromosomes proteinUniRule annotation |
Gene namesi | Name:SMC1AImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:59007, SMC1A |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Other locations
- Chromosome ARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cohesin complex Source: InterPro
Keywords - Cellular componenti
ChromosomeARBA annotation, NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSECAG00000019776, Expressed in embryo and 23 other tissues |
ExpressionAtlasi | F7CM75, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 513 – 629 | SMC hingeInterPro annotationAdd BLAST | 117 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 284 – 308 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 348 – 369 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 947 – 968 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1215 – 1239 | DisorderedSequence analysisAdd BLAST | 25 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 189 – 222 | Sequence analysisAdd BLAST | 34 | |
Coiled coili | 407 – 490 | Sequence analysisAdd BLAST | 84 | |
Coiled coili | 664 – 711 | Sequence analysisAdd BLAST | 48 | |
Coiled coili | 748 – 775 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 789 – 814 | Sequence analysisAdd BLAST | 26 | |
Coiled coili | 828 – 925 | Sequence analysisAdd BLAST | 98 | |
Coiled coili | 992 – 1016 | Sequence analysisAdd BLAST | 25 | |
Coiled coili | 1024 – 1065 | Sequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 949 – 968 | PolarSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the SMC family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155614 |
HOGENOMi | CLU_057899_1_1_1 |
InParanoidi | F7CM75 |
Family and domain databases
CDDi | cd03275, ABC_SMC1_euk, 2 hits |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR003395, RecF/RecN/SMC_N IPR024704, SMC IPR028468, Smc1_ABC IPR029683, SMC1A_metazoan IPR010935, SMC_hinge IPR036277, SMC_hinge_sf |
PANTHERi | PTHR18937:SF170, PTHR18937:SF170, 1 hit |
Pfami | View protein in Pfam PF06470, SMC_hinge, 1 hit PF02463, SMC_N, 1 hit |
PIRSFi | PIRSF005719, SMC, 1 hit |
SMARTi | View protein in SMART SM00968, SMC_hinge, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF75553, SSF75553, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
F7CM75-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGFLKLIEIE NFKSYKGRQI IGPFQRFTAI IGPNGSGKSN LMDAISFVLG
60 70 80 90 100
EKTSNLRVKT LRDLIHGAPV GKPAANRAFV SMVYSEEGAE DRTFARVIVG
110 120 130 140 150
GSSEYKINNK VVQLHEYSEE LEKLGILIKA RNFLVFQGAV ESIAMKNPKE
160 170 180 190 200
RTALFEEISR SGELAQEYDK RKKEMVKAEE DTQFNYHRKK NIAAERKEAK
210 220 230 240 250
QEKEEADRYQ RLKDEVVRAQ VQLQLFKLYH NEVEIEKLNK ELASKNKEIE
260 270 280 290 300
KDKKRMDKVE DELKEKKKEL GKMMREQQQI EKEIKEKDSE LNQKRPQYIK
310 320 330 340 350
AKENTSHKIK KLEAAKKSLQ NAQKHYKKRK GDMDELEKEM LSVEKARQEF
360 370 380 390 400
EERMEEESQS QGRDLTLEEN QVKKYHRLKE EASKRAATLA QELEKFNRDQ
410 420 430 440 450
KADQDRLDLE ERKKVETEAK IKQKLREIEE NQKRIEKLEE YITTSKQSLE
460 470 480 490 500
EQKKLEGELT EEVEMAKRRI DEINKELNQV MEQLGDARID RQESSRQQRK
510 520 530 540 550
AEIMESIKRL YPGSVYGRLI DLCQPTQKKY QIAVTKVLGK NMDAIIVDSE
560 570 580 590 600
KTGRDCIQYI KEQRGEPETF LPLDYLEVKP TDEKLRELKG AKLVIDVIRY
610 620 630 640 650
EPPHIKKALQ YACGNALVCD NVEDARRIAF GGHQRHKTVA LDGTLFQKSG
660 670 680 690 700
VISGGASDLK AKARRWDEKA VDKLKEKKER LTEELKEQMK AKRKEAELRQ
710 720 730 740 750
VQSQAHGLQM RLKYSQSDLE QTKTRHLALN LQEKSKLESE LANFGPRIND
760 770 780 790 800
IKRIIQSRER EMKDLKEKMN QVEDEVFEEF CREIGVRNIR EFEEEKVKRQ
810 820 830 840 850
NEIAKKRLEF ENQKTRLGIQ LDFEKNQLKE DQDKVHMWEQ TVKKDENEIE
860 870 880 890 900
KLKKEEQRHM KIIDETMAQL QDLKNQHLAK KSEVNDKNHE MEEIRKKLGG
910 920 930 940 950
ANKEMTHLQK EVTAIETKLE QKRSDRHNLL QACKMQDIKL PLSKGTMDDI
960 970 980 990 1000
SQEEGSSQGE DSVSGSQRTS NIYAREALIE IDYGDLCEDL KDAQAEEEIK
1010 1020 1030 1040 1050
QEMNTLQQKL NEQQSVLQRI AAPNMKAMEK LESVRDKFQE TSDEFEAARK
1060 1070 1080 1090 1100
RAKKAKQAFE QIKKERFDRF NACFESVATN IDEIYKALSR NSSAQAFLGP
1110 1120 1130 1140 1150
ENPEEPYLDG INYNCVAPGK RFRPMDNLSG GEKTVAALAL LFAIHSYKPA
1160 1170 1180 1190 1200
PFFVLDEIDA ALDNTNIGKV ANYIKEQSTC NFQAIVISLK EEFYTKAESL
1210 1220 1230
IGVYPEVGRA WLRSQPHSLP DSPGQEGMAA VEGHWGGGA
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F5PJH7 | A0A5F5PJH7_HORSE | Structural maintenance of chromosom... | SMC1A | 1,401 | Annotation score: | ||
A0A5F5PHS5 | A0A5F5PHS5_HORSE | Structural maintenance of chromosom... | SMC1A | 1,397 | Annotation score: | ||
A0A5F5PWV0 | A0A5F5PWV0_HORSE | Structural maintenance of chromosom... | SMC1A | 1,391 | Annotation score: | ||
A0A3Q2GTQ7 | A0A3Q2GTQ7_HORSE | Structural maintenance of chromosom... | SMC1A | 1,379 | Annotation score: | ||
A0A3Q2H992 | A0A3Q2H992_HORSE | Structural maintenance of chromosom... | SMC1A | 1,298 | Annotation score: | ||
A0A3Q2I7I7 | A0A3Q2I7I7_HORSE | Structural maintenance of chromosom... | SMC1A | 1,292 | Annotation score: | ||
A0A3Q2LCU8 | A0A3Q2LCU8_HORSE | Structural maintenance of chromosom... | SMC1A | 1,327 | Annotation score: | ||
F6V5A0 | F6V5A0_HORSE | Structural maintenance of chromosom... | SMC1A | 269 | Annotation score: | ||
A0A5F5PM20 | A0A5F5PM20_HORSE | Structural maintenance of chromosom... | SMC1A | 169 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000020951; ENSECAP00000017226; ENSECAG00000019776 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F7CM75 |
Genome annotation databases
Ensembli | ENSECAT00000020951; ENSECAP00000017226; ENSECAG00000019776 |
Organism-specific databases
VGNCi | VGNC:59007, SMC1A |
Phylogenomic databases
GeneTreei | ENSGT00940000155614 |
HOGENOMi | CLU_057899_1_1_1 |
InParanoidi | F7CM75 |
Gene expression databases
Bgeei | ENSECAG00000019776, Expressed in embryo and 23 other tissues |
ExpressionAtlasi | F7CM75, baseline |
Family and domain databases
CDDi | cd03275, ABC_SMC1_euk, 2 hits |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR003395, RecF/RecN/SMC_N IPR024704, SMC IPR028468, Smc1_ABC IPR029683, SMC1A_metazoan IPR010935, SMC_hinge IPR036277, SMC_hinge_sf |
PANTHERi | PTHR18937:SF170, PTHR18937:SF170, 1 hit |
Pfami | View protein in Pfam PF06470, SMC_hinge, 1 hit PF02463, SMC_N, 1 hit |
PIRSFi | PIRSF005719, SMC, 1 hit |
SMARTi | View protein in SMART SM00968, SMC_hinge, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF75553, SSF75553, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7CM75_HORSE | |
Accessioni | F7CM75Primary (citable) accession number: F7CM75 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | April 7, 2021 | |
This is version 59 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |