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Entry version 49 (10 Feb 2021)
Sequence version 3 (11 Dec 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

LOC100072601

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC100072601Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F7CKU6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000020002, Expressed in oviduct epithelium and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini967 – 1010DoublecortinInterPro annotationAdd BLAST44
Domaini1162 – 1264Ricin B-type lectinInterPro annotationAdd BLAST103
Domaini1410 – 1476DoublecortinInterPro annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 38DisorderedSequence analysisAdd BLAST38
Regioni93 – 119DisorderedSequence analysisAdd BLAST27
Regioni817 – 841DisorderedSequence analysisAdd BLAST25
Regioni1580 – 1602DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili397 – 417Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 26PolarSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163628

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011373_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7CKU6

TreeFam database of animal gene trees

More...
TreeFami
TF329467

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00161, RICIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043188, DCDC1
IPR003533, Doublecortin_dom
IPR036572, Doublecortin_dom_sf
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin

The PANTHER Classification System

More...
PANTHERi
PTHR46302, PTHR46302, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00537, DCX, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50370, SSF50370, 2 hits
SSF89837, SSF89837, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50309, DC, 2 hits
PS50231, RICIN_B_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F7CKU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANTETEDHR AAVSPSSLSP LTEAVEGQPS SPEGAFRGDT VIPIDKCISS
60 70 80 90 100
DLPRGCMSSQ AKAVMKSTED FLQPQFGPNR CVHPAAVSEG SGCQDCSTHQ
110 120 130 140 150
TASGHSHDEV TDPHSCKSNS RDNSCFMSAS KRNRPASAPA GQLRVAEFSS
160 170 180 190 200
LKFQPAQNCH RLCQRHKPPP RVIRVTAYRN GSRAVCAKVT APTITLLLEM
210 220 230 240 250
CTEKLHLNMA ARRVFLADGS EALRPEDIPH EADMYVSTGE PFLDPFKKIK
260 270 280 290 300
DHLLLMKKVT WTMNGVMLPT DVKRQKTKPV LSIRMKKLTE KTSVRILFFK
310 320 330 340 350
NGMGQDGHEI TVEKETMRKV LDTCTMRMNL NSPARYLYDL YGRKIKDVSK
360 370 380 390 400
VPLLEKCLQN SITPLRGPVW VSKGEGFSPS GAKMYLQGVL LALYQRLRSA
410 420 430 440 450
QKYYKQLNMA VDKQKEKITE KVILSMTAKG LHQTQEEVSG LIDELQTAIK
460 470 480 490 500
SNRGHLSKLG PQLQAEQEQF SSYVYQHIKS LPTNTLLPGG LQLKIFENGK
510 520 530 540 550
DTGEISVFIS KKDLGSNSPA HTGDVMERLL LKIHQRLQGS SINPSGLNFS
560 570 580 590 600
STRLFDEHGH EIRNPLLLKN GQKLWVSHGE AYRSPLNPVL GLTFDQVAAF
610 620 630 640 650
ARGGITVAYK TFLDPSAALL PGCDNWEVCE GFPINFSGTS QQIPDQFETV
660 670 680 690 700
DLGNHFLQNK VDPSIILHAS VSVAKQSFSG TAASGGSQMV TSTLWPAASV
710 720 730 740 750
WLITKTGMIL SRAVTQGCLA VGCPIRVKAA DGASLDGHKL ILQKRDKGND
760 770 780 790 800
AQKWVFGTDG CIYSKAYPQF ALTYLEELNA QVDVTQMESH IHHGARTTAH
810 820 830 840 850
QEHGSSLAEE VLQKSAGVPG LKQPPEPADT GLMPEGSPGE TGRLTVAVMR
860 870 880 890 900
KLEGKHPQAS AQRWAIKHEG TKKPGQWKHS RVENPLWNKL TYMWPVLPSG
910 920 930 940 950
QLNEEFDWPL EGLLVANSPP LKRPVCKTLE LHAPVRLRVV RNGDKNKSRA
960 970 980 990 1000
LSITGPDISP GRKTQCTETL HLPSAARRLF NEEGQEVLAL KDLQRDELVY
1010 1020 1030 1040 1050
VSRGEDWINP DLSTAQQKRQ ILLRNLTSDV SKMQIFCSTR KTETLVLEVQ
1060 1070 1080 1090 1100
SDIVSGAKLA VRKPVEIFGE EKQIIEPEEK QMQKNALTTE NASSEILDAH
1110 1120 1130 1140 1150
ARAHLRGKAR GPVVRYAWQD TSGDLQQHGG PPEKVEELFD DAHPQEEDSR
1160 1170 1180 1190 1200
SPRQSKWQKL CHQQFEYRDA QIISHAVPQL ALGVPGPDLH SGTEVVLVEK
1210 1220 1230 1240 1250
KADDGRQRWM HKKGSRTFHL VSDPELVLAV SMTKAGNEVC GYPVIVQKYK
1260 1270 1280 1290 1300
PYKNGASNQR WKYVESVKAF VAFHSTALDK ETTAAHYAGV CTASVIKGEN
1310 1320 1330 1340 1350
VHQPGYYYLS PAGKKETMLC LACGQSRRAE KGLKLLLPGL PFLCASGSQT
1360 1370 1380 1390 1400
QKPFSRGPFK AITVAEADLS SYKAEKTLGY YEDRLSSLRT KTRTQVVSHS
1410 1420 1430 1440 1450
GMAATHQKAV KIIAYRNGDG YRNGKLIVAG TFPMLLTECT ERLGLARAAS
1460 1470 1480 1490 1500
KVYTEDGTAV CSLRDLVLWA LGESFIQRDS EGRKKEAAPV GTEETTVKKN
1510 1520 1530 1540 1550
PRMQVKTKLF PQSVPTDSLD DVDRSRLAFV LRNPIAVWIS CGEPFLSPNA
1560 1570 1580 1590 1600
LQKAEKLEKQ NWLKKDKILA DLDTMKHKMR QLRGRRVAAR QPATMAPNKS
1610 1620 1630 1640 1650
PVQPVLVEGS WAEKTREEIK LMDLIRHTEA HLSEVQERQH KRNSPIPAAR
1660 1670 1680 1690 1700
TALGQSSLYK QPNAKRVWIY RNGGRPADGA YAWGRTISGL LDDCSSRLGM
1710 1720 1730 1740 1750
AQPTRALYTP GGKPLHSWDD IERDMVVCVS TGHSFTTQEE LKQLMEVRAN
1760 1770 1780
YARIRRQQGP QATDIVVLPS SKLRSLVSVC GE
Length:1,782
Mass (Da):197,504
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC420B83531FBA34
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000021316; ENSECAP00000017548; ENSECAG00000020002

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF7CKU6

Genome annotation databases

EnsembliENSECAT00000021316; ENSECAP00000017548; ENSECAG00000020002

Phylogenomic databases

GeneTreeiENSGT00940000163628
HOGENOMiCLU_011373_0_0_1
InParanoidiF7CKU6
TreeFamiTF329467

Gene expression databases

BgeeiENSECAG00000020002, Expressed in oviduct epithelium and 14 other tissues

Family and domain databases

CDDicd00161, RICIN, 1 hit
InterProiView protein in InterPro
IPR043188, DCDC1
IPR003533, Doublecortin_dom
IPR036572, Doublecortin_dom_sf
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin
PANTHERiPTHR46302, PTHR46302, 3 hits
SMARTiView protein in SMART
SM00537, DCX, 3 hits
SUPFAMiSSF50370, SSF50370, 2 hits
SSF89837, SSF89837, 5 hits
PROSITEiView protein in PROSITE
PS50309, DC, 2 hits
PS50231, RICIN_B_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7CKU6_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7CKU6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: February 10, 2021
This is version 49 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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