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UniProtKB - F7CKU6 (F7CKU6_HORSE)

Entry version 49 (10 Feb 2021)
Sequence version 3 (11 Dec 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

LOC100072601

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC100072601Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		F7CKU6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSECAG00000020002, Expressed in oviduct epithelium and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini967 – 1010DoublecortinInterPro annotationAdd BLAST44
Domaini1162 – 1264Ricin B-type lectinInterPro annotationAdd BLAST103
Domaini1410 – 1476DoublecortinInterPro annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 38DisorderedSequence analysisAdd BLAST38
Regioni93 – 119DisorderedSequence analysisAdd BLAST27
Regioni817 – 841DisorderedSequence analysisAdd BLAST25
Regioni1580 – 1602DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili397 – 417Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 26PolarSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163628

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011373_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F7CKU6

TreeFam database of animal gene trees

More...TreeFami		TF329467

Family and domain databases

Conserved Domains Database

More...CDDi		cd00161, RICIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043188, DCDC1
IPR003533, Doublecortin_dom
IPR036572, Doublecortin_dom_sf
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin

The PANTHER Classification System

More...PANTHERi		PTHR46302, PTHR46302, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00537, DCX, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50370, SSF50370, 2 hits
SSF89837, SSF89837, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50309, DC, 2 hits
PS50231, RICIN_B_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F7CKU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANTETEDHR AAVSPSSLSP LTEAVEGQPS SPEGAFRGDT VIPIDKCISS 
        60         70         80         90        100
DLPRGCMSSQ AKAVMKSTED FLQPQFGPNR CVHPAAVSEG SGCQDCSTHQ 
       110        120        130        140        150
TASGHSHDEV TDPHSCKSNS RDNSCFMSAS KRNRPASAPA GQLRVAEFSS 
       160        170        180        190        200
LKFQPAQNCH RLCQRHKPPP RVIRVTAYRN GSRAVCAKVT APTITLLLEM 
       210        220        230        240        250
CTEKLHLNMA ARRVFLADGS EALRPEDIPH EADMYVSTGE PFLDPFKKIK 
       260        270        280        290        300
DHLLLMKKVT WTMNGVMLPT DVKRQKTKPV LSIRMKKLTE KTSVRILFFK 
       310        320        330        340        350
NGMGQDGHEI TVEKETMRKV LDTCTMRMNL NSPARYLYDL YGRKIKDVSK 
       360        370        380        390        400
VPLLEKCLQN SITPLRGPVW VSKGEGFSPS GAKMYLQGVL LALYQRLRSA 
       410        420        430        440        450
QKYYKQLNMA VDKQKEKITE KVILSMTAKG LHQTQEEVSG LIDELQTAIK 
       460        470        480        490        500
SNRGHLSKLG PQLQAEQEQF SSYVYQHIKS LPTNTLLPGG LQLKIFENGK 
       510        520        530        540        550
DTGEISVFIS KKDLGSNSPA HTGDVMERLL LKIHQRLQGS SINPSGLNFS 
       560        570        580        590        600
STRLFDEHGH EIRNPLLLKN GQKLWVSHGE AYRSPLNPVL GLTFDQVAAF 
       610        620        630        640        650
ARGGITVAYK TFLDPSAALL PGCDNWEVCE GFPINFSGTS QQIPDQFETV 
       660        670        680        690        700
DLGNHFLQNK VDPSIILHAS VSVAKQSFSG TAASGGSQMV TSTLWPAASV 
       710        720        730        740        750
WLITKTGMIL SRAVTQGCLA VGCPIRVKAA DGASLDGHKL ILQKRDKGND 
       760        770        780        790        800
AQKWVFGTDG CIYSKAYPQF ALTYLEELNA QVDVTQMESH IHHGARTTAH 
       810        820        830        840        850
QEHGSSLAEE VLQKSAGVPG LKQPPEPADT GLMPEGSPGE TGRLTVAVMR 
       860        870        880        890        900
KLEGKHPQAS AQRWAIKHEG TKKPGQWKHS RVENPLWNKL TYMWPVLPSG 
       910        920        930        940        950
QLNEEFDWPL EGLLVANSPP LKRPVCKTLE LHAPVRLRVV RNGDKNKSRA 
       960        970        980        990       1000
LSITGPDISP GRKTQCTETL HLPSAARRLF NEEGQEVLAL KDLQRDELVY 
      1010       1020       1030       1040       1050
VSRGEDWINP DLSTAQQKRQ ILLRNLTSDV SKMQIFCSTR KTETLVLEVQ 
      1060       1070       1080       1090       1100
SDIVSGAKLA VRKPVEIFGE EKQIIEPEEK QMQKNALTTE NASSEILDAH 
      1110       1120       1130       1140       1150
ARAHLRGKAR GPVVRYAWQD TSGDLQQHGG PPEKVEELFD DAHPQEEDSR 
      1160       1170       1180       1190       1200
SPRQSKWQKL CHQQFEYRDA QIISHAVPQL ALGVPGPDLH SGTEVVLVEK 
      1210       1220       1230       1240       1250
KADDGRQRWM HKKGSRTFHL VSDPELVLAV SMTKAGNEVC GYPVIVQKYK 
      1260       1270       1280       1290       1300
PYKNGASNQR WKYVESVKAF VAFHSTALDK ETTAAHYAGV CTASVIKGEN 
      1310       1320       1330       1340       1350
VHQPGYYYLS PAGKKETMLC LACGQSRRAE KGLKLLLPGL PFLCASGSQT 
      1360       1370       1380       1390       1400
QKPFSRGPFK AITVAEADLS SYKAEKTLGY YEDRLSSLRT KTRTQVVSHS 
      1410       1420       1430       1440       1450
GMAATHQKAV KIIAYRNGDG YRNGKLIVAG TFPMLLTECT ERLGLARAAS 
      1460       1470       1480       1490       1500
KVYTEDGTAV CSLRDLVLWA LGESFIQRDS EGRKKEAAPV GTEETTVKKN 
      1510       1520       1530       1540       1550
PRMQVKTKLF PQSVPTDSLD DVDRSRLAFV LRNPIAVWIS CGEPFLSPNA 
      1560       1570       1580       1590       1600
LQKAEKLEKQ NWLKKDKILA DLDTMKHKMR QLRGRRVAAR QPATMAPNKS 
      1610       1620       1630       1640       1650
PVQPVLVEGS WAEKTREEIK LMDLIRHTEA HLSEVQERQH KRNSPIPAAR 
      1660       1670       1680       1690       1700
TALGQSSLYK QPNAKRVWIY RNGGRPADGA YAWGRTISGL LDDCSSRLGM 
      1710       1720       1730       1740       1750
AQPTRALYTP GGKPLHSWDD IERDMVVCVS TGHSFTTQEE LKQLMEVRAN 
      1760       1770       1780 
YARIRRQQGP QATDIVVLPS SKLRSLVSVC GE
Length:1,782
Mass (Da):197,504
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC420B83531FBA34
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSECAT00000021316; ENSECAP00000017548; ENSECAG00000020002

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PaxDbiF7CKU6

Genome annotation databases

EnsembliENSECAT00000021316; ENSECAP00000017548; ENSECAG00000020002

Phylogenomic databases

GeneTreeiENSGT00940000163628
HOGENOMiCLU_011373_0_0_1
InParanoidiF7CKU6
TreeFamiTF329467

Gene expression databases

BgeeiENSECAG00000020002, Expressed in oviduct epithelium and 14 other tissues

Family and domain databases

CDDicd00161, RICIN, 1 hit
InterProiView protein in InterPro
IPR043188, DCDC1
IPR003533, Doublecortin_dom
IPR036572, Doublecortin_dom_sf
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin
PANTHERiPTHR46302, PTHR46302, 3 hits
SMARTiView protein in SMART
SM00537, DCX, 3 hits
SUPFAMiSSF50370, SSF50370, 2 hits
SSF89837, SSF89837, 5 hits
PROSITEiView protein in PROSITE
PS50309, DC, 2 hits
PS50231, RICIN_B_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7CKU6_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7CKU6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: February 10, 2021
This is version 49 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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